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Science 12 March 1999:
Vol. 283. no. 5408, p. 1669
DOI: 10.1126/science.283.5408.1669
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SINGLE MOLECULES:
Deconstructing DNA for Faster Sequencing

Robert F. Service

At the heart of the international race to sequence the human genome are machines that create thousands of copies of DNA fragments as a first step toward decoding their sequence, one nucleotide base pair at a time. But a handful of groups around the world are working on new approaches that decode single copies of DNA directly using molecular probes--approaches which have the potential to simplify and speed up the sequencing process.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Single metallic nanoparticle imaging for protein detection in cells.
L. Cognet, C. Tardin, D. Boyer, D. Choquet, P. Tamarat, and B. Lounis (2003)
PNAS 100, 11350-11355
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Science. ISSN 0036-8075 (print), 1095-9203 (online)