Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
SNM Organization

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 19 February 1999:
Vol. 283. no. 5405, pp. 1124 - 1125
DOI: 10.1126/science.283.5405.1124
Prev | Table of Contents | Next

Perspectives

IMMUNOLOGY:
T Cells and Dendritic Cells Get Intimate

Kim Bottomly

Dendritic cells (DCs) are capable of both antigen presentation and CD4 T cell activation. A study in this week's issue by Rissoan and colleagues, discussed in the Perspective by Bottomly, now shows one way in which DCs determine the selectivity of the T cell immune response. Myeloid-like DCs produce interleukin-12, which skews T cell differentiation toward a T helper 1 (TH1) response, whereas lymphoid-like DCs favor a TH2 response.

The author is in the Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-801, USA. E-mail: kim.bottomly{at}yale.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance.
Y. S. Kim, S. H. Yang, H. G. Kang, E. Y. Seong, S. H. Lee, W. Gao, J. Kenny, X. X. Zheng, and T. B. Strom (2006)
Int. Immunol. 18, 1771-1777
   Abstract »    Full Text »    PDF »
Dendritic Cell Trafficking and Antigen Presentation in the Human Immune Response to Mycobacterium tuberculosis.
S. Marino, S. Pawar, C. L. Fuller, T. A. Reinhart, J. L. Flynn, and D. E. Kirschner (2004)
J. Immunol. 173, 494-506
   Abstract »    Full Text »    PDF »
A Novel Dendritic Cell-Induced Model of Erosive Inflammatory Arthritis: Distinct Roles for Dendritic Cells in T Cell Activation and Induction of Local Inflammation.
B. P. Leung, M. Conacher, D. Hunter, I. B. McInnes, F. Y. Liew, and J. M. Brewer (2002)
J. Immunol. 169, 7071-7077
   Abstract »    Full Text »    PDF »
Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability.
M. Rodriguez-Sosa, A. R. Satoskar, R. Calderon, L. Gomez-Garcia, R. Saavedra, R. Bojalil, and L. I. Terrazas (2002)
Infect. Immun. 70, 3656-3664
   Abstract »    Full Text »    PDF »
Memorizing innate instructions requires a sufficiently specific adaptive immune system.
J. A. M. Borghans and R. J. De Boer (2002)
Int. Immunol. 14, 525-532
   Abstract »    Full Text »    PDF »
Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development.
M. B. Faries, I. Bedrosian, S. Xu, G. Koski, J. G. Roros, M. A. Moise, H. Q. Nguyen, F. H. C. Engels, P. A. Cohen, and B. J. Czerniecki (2001)
Blood 98, 2489-2497
   Abstract »    Full Text »    PDF »
Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life.
T Tschernig, A S Debertin, F Paulsen, W J Kleemann, and R Pabst (2001)
Thorax 56, 427-431
   Abstract »    Full Text »
Identification of a leukemic counterpart of the plasmacytoid dendritic cells.
L. Chaperot, N. Bendriss, O. Manches, R. Gressin, M. Maynadie, F. Trimoreau, H. Orfeuvre, B. Corront, J. Feuillard, J.-J. Sotto, et al. (2001)
Blood 97, 3210-3217
   Abstract »    Full Text »    PDF »
Signal-regulatory protein {alpha} (SIRP{alpha}) but not SIRP{beta} is involved in T-cell activation, binds to CD47 with high affinity, and is expressed on immature CD34+CD38{-} hematopoietic cells.
M. Seiffert, P. Brossart, C. Cant, M. Cella, M. Colonna, W. Brugger, L. Kanz, A. Ullrich, and H.-J. Buhring (2001)
Blood 97, 2741-2749
   Abstract »    Full Text »    PDF »
Monocyte-Derived CD1a+ and CD1a- Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentiation.
C.-C. J. Chang, A. Wright, and J. Punnonen (2000)
J. Immunol. 165, 3584-3591
   Abstract »    Full Text »    PDF »
In Vivo Effects of Sex Steroids on Lymphocyte Responsiveness and Immunoglobulin Levels in Humans.
E. J. Giltay, J. C. M. Fonk, B. M. E. von Blomberg, H. A. Drexhage, C. Schalkwijk, and L. J. G. Gooren (2000)
J. Clin. Endocrinol. Metab. 85, 1648-1657
   Abstract »    Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)