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Science 5 February 1999:
Vol. 283. no. 5403, pp. 806 - 809
DOI: 10.1126/science.283.5403.806
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Population Biology, Evolution, and Infectious Disease: Convergence and Synthesis

Bruce R. Levin, 1 Marc Lipsitch, 1 Sebastian Bonhoeffer 2

Traditionally, the interest of population and evolutionary biologists in infectious diseases has been almost exclusively in their role as agents of natural selection in higher organisms. Recently, this interest has expanded to include the genetic structure and evolution of microparasite populations, the mechanisms of pathogenesis and the immune response, and the population biology, ecology, and evolutionary consequences of medical and public health interventions. This article describes recent work in these areas, emphasizing the ways in which quantitative, population-biological approaches have been contributing to the understanding of infectious disease and the design and evaluation of interventions for their treatment and prevention.

1 Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
2 Friedrich Miescher Institute, Maulbeerstrasse 66, CH-4058 Basel, Switzerland, and Institute for Experimental Ecology, Eidgenössische Technische Hochschule (ETH) Zürich, ETH Zentrum NW, CH-8092 Zürich, Switzerland.

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