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Science 29 January 1999:
Vol. 283. no. 5402, pp. 680 - 682
DOI: 10.1126/science.283.5402.680
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Reports

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

Antonella Viola, * Susanne Schroeder, Yoichi Sakakibara, Antonio Lanzavecchia

Although dispensable, costimulation through CD28 facilitates activation of naïve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland.
*   To whom correspondence should be addressed. E-mail: viola{at}bii.ch

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Cofilin peptide homologs interfere with immunological synapse formation and T cell activation.
S. M. Eibert, K.-H. Lee, R. Pipkorn, U. Sester, G. H. Wabnitz, T. Giese, S. C. Meuer, and Y. Samstag (2004)
PNAS 101, 1957-1962
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Actin Cytoskeleton Regulates Calcium Dynamics and NFAT Nuclear Duration.
F. V. Rivas, J. P. O'Keefe, M.-L. Alegre, and T. F. Gajewski (2004)
Mol. Cell. Biol. 24, 1628-1639
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