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Science 29 January 1999:
Vol. 283. no. 5402, pp. 676 - 679
DOI: 10.1126/science.283.5402.676
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Reports

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2, by c-MYC

Kou-Juey Wu, Axel Polack, Riccardo Dalla-Favera *

The protein encoded by the c-MYC proto-oncogene is a transcription factor that can both activate and repress the expression of target genes, but few of its transcriptional targets have been identified. Here, c-MYC is shown to repress the expression of the heavy subunit of the protein ferritin (H-ferritin), which sequesters intracellular iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the intracellular iron pool. Down-regulation of the expression of H-ferritin gene was required for cell transformation by c-MYC. These results indicate that c-MYC coordinately regulates genes controlling intracellular iron concentrations and that this function is essential for the control of cell proliferation and transformation by c-MYC.

K.-J. Wu and R. Dalla-Favera, Division of Oncology, Department of Pathology, Columbia University, New York, NY 10032, USA. A. Polack, Institute for Clinical Molecular Biology and Tumor Genetics, GSF, National Research Institute for Environment and Health, Marchioninistrasse 25, D-81377 Munchen, Germany.
*   To whom correspondence should be addressed. E-mail: rd10{at}columbia.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)