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Science 29 January 1999:
Vol. 283. no. 5402, pp. 649 - 650
DOI: 10.1126/science.283.5402.649
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Perspectives

IMMUNOLOGY:
Costimulation: Building an Immunological Synapse

Michael L. Dustin and Andrey S. Shaw

Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results (Viola et al. in this issue) begin to characterize the process by which this structure is formed and define its components.

The authors are in the Department of Pathology and Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. E-mail: dustin{at}pathbox.wustl.edu

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