Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 January 1999:
Vol. 283. no. 5401, pp. 543 - 546
DOI: 10.1126/science.283.5401.543
Prev | Table of Contents | Next

Reports

Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains

Yingping Jiang, John D. Woronicz, Wei Liu, David V. Goeddel *

Tumor necrosis factor receptor type 1 (TNF-R1) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B (NF-kappa B) activation. Normally, these signals are generated only after TNF-induced receptor aggregation. However, TNF-R1 self-associates and signals independently of ligand when overexpressed. This apparent paradox may be explained by silencer of death domains (SODD), a widely expressed ~60-kilodalton protein that was found to be associated with the death domain of TNF-R1. TNF treatment released SODD from TNF-R1, permitting the recruitment of proteins such as TRADD and TRAF2 to the active TNF-R1 signaling complex. SODD also interacted with death receptor-3 (DR3), another member of the TNF receptor superfamily. Thus, SODD association may be representative of a general mechanism for preventing spontaneous signaling by death domain-containing receptors.

Tularik, Two Corporate Drive, South San Francisco, CA 94080, USA.
*   To whom correspondence should be addressed. E-mail: goeddel{at}tularik.com

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of Critical Residues within the Conserved and Specificity Patches of Nerve Growth Factor Leading to Survival or Differentiation.
S. Mahapatra, H. Mehta, S. B. Woo, and K. E. Neet (2009)
J. Biol. Chem. 284, 33600-33613
   Abstract »    Full Text »    PDF »
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF{kappa}B.
T. Lu, M. W. Jackson, A. D. Singhi, E. S. Kandel, M. Yang, Y. Zhang, A. V. Gudkov, and G. R. Stark (2009)
PNAS 106, 16339-16344
   Abstract »    Full Text »    PDF »
A link between SIN1 (MAPKAP1) and poly(rC) binding protein 2 (PCBP2) in counteracting environmental stress.
D. Ghosh, G. P. Srivastava, D. Xu, L. C. Schulz, and R. M. Roberts (2008)
PNAS 105, 11673-11678
   Abstract »    Full Text »    PDF »
Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1..
T. Kato Jr, Y. Gotoh, A. Hoffmann, and Y. Ono (2008)
Genes Cells 13, 509-520
   Abstract »    Full Text »    PDF »
BAG-4/SODD and Associated Antiapoptotic Proteins Are Linked to Aggressiveness of Epithelial Ovarian Cancer.
C. M. Annunziata, L. Kleinberg, B. Davidson, A. Berner, D. Gius, N. Tchabo, S. M. Steinberg, and E. C. Kohn (2007)
Clin. Cancer Res. 13, 6585-6592
   Abstract »    Full Text »    PDF »
The Long Form of Fas Apoptotic Inhibitory Molecule Is Expressed Specifically in Neurons and Protects Them against Death Receptor-Triggered Apoptosis.
M. F. Segura, C. Sole, M. Pascual, R. S. Moubarak, M. Jose Perez-Garcia, R. Gozzelino, V. Iglesias, N. Badiola, J. R. Bayascas, N. Llecha, et al. (2007)
J. Neurosci. 27, 11228-11241
   Abstract »    Full Text »    PDF »
RIP1-mediated AIP1 Phosphorylation at a 14-3-3-binding Site Is Critical for Tumor Necrosis Factor-induced ASK1-JNK/p38 Activation.
R. Zhang, H. Zhang, Y. Lin, J. Li, J. S. Pober, and W. Min (2007)
J. Biol. Chem. 282, 14788-14796
   Abstract »    Full Text »    PDF »
Differential Functions of Tumor Necrosis Factor Receptor 1 and 2 Signaling in Ischemia-Mediated Arteriogenesis and Angiogenesis.
D. Luo, Y. Luo, Y. He, H. Zhang, R. Zhang, X. Li, W. L. Dobrucki, A. J. Sinusas, W. C. Sessa, and W. Min (2006)
Am. J. Pathol. 169, 1886-1898
   Abstract »    Full Text »    PDF »
Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein.
K. Saito, K. Meyer, R. Warner, A. Basu, R. B. Ray, and R. Ray (2006)
J. Virol. 80, 4372-4379
   Abstract »    Full Text »    PDF »
Competitive Control of Independent Programs of Tumor Necrosis Factor Receptor-Induced Cell Death by TRADD and RIP1..
L. Zheng, N. Bidere, D. Staudt, A. Cubre, J. Orenstein, F. K. Chan, and M. Lenardo (2006)
Mol. Cell. Biol. 26, 3505-3513
   Abstract »    Full Text »    PDF »
Drosophila starvin Encodes a Tissue-Specific BAG-Domain Protein Required for Larval Food Uptake.
M. Coulson, S. Robert, and R. Saint (2005)
Genetics 171, 1799-1812
   Abstract »    Full Text »    PDF »
Fas-associated Protein with Death Domain (FADD)-independent Recruitment of c-FLIPL to Death Receptor 5.
T.-G. Jin, A. Kurakin, N. Benhaga, K. Abe, M. Mohseni, F. Sandra, K. Song, B. K. Kay, and R. Khosravi-Far (2004)
J. Biol. Chem. 279, 55594-55601
   Abstract »    Full Text »    PDF »
A Death Receptor-associated Anti-apoptotic Protein, BRE, Inhibits Mitochondrial Apoptotic Pathway.
Q. Li, A. K.-K. Ching, B. C.-L. Chan, S. K.-Y. Chow, P.-L. Lim, T. C.-Y. Ho, W.-K. Ip, C.-K. Wong, C. W.-K. Lam, K. K.-H. Lee, et al. (2004)
J. Biol. Chem. 279, 52106-52116
   Abstract »    Full Text »    PDF »
AIP1/DAB2IP, a Novel Member of the Ras-GAP Family, Transduces TRAF2-induced ASK1-JNK Activation.
H. Zhang, R. Zhang, Y. Luo, A. D'Alessio, J. S. Pober, and W. Min (2004)
J. Biol. Chem. 279, 44955-44965
   Abstract »    Full Text »    PDF »
Proteomic Identification of Bcl2-associated Athanogene 2 as a Novel MAPK-activated Protein Kinase 2 Substrate.
K. Ueda, H. Kosako, Y. Fukui, and S. Hattori (2004)
J. Biol. Chem. 279, 41815-41821
   Abstract »    Full Text »    PDF »
Signaling to NF-{kappa}B.
M. S. Hayden and S. Ghosh (2004)
Genes & Dev. 18, 2195-2224
   Abstract »    Full Text »    PDF »
Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression.
A. M. Siwkowski, L. A. Madge, S. Koo, E. L. McMillan, B. P. Monia, J. S. Pober, and B. F. Baker (2004)
Mol. Pharmacol. 66, 572-579
   Abstract »    Full Text »    PDF »
Antibodies Immobilized as Arrays to Profile Protein Post-translational Modifications in Mammalian Cells.
S. S. Ivanov, A. S. Chung, Z.-l. Yuan, Y.-j. Guan, K. V. Sachs, J. S. Reichner, and Y. E. Chin (2004)
Mol. Cell. Proteomics 3, 788-795
   Abstract »    Full Text »    PDF »
Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: A mechanism for generation of soluble cytokine receptors.
F. I. Hawari, F. N. Rouhani, X. Cui, Z.-X. Yu, C. Buckley, M. Kaler, and S. J. Levine (2004)
PNAS 101, 1297-1302
   Abstract »    Full Text »    PDF »
Mutant human cells with constitutive activation of NF-{kappa}B.
S. S. Sathe, N. Sizemore, X. Li, K. Vithalani, M. Commane, S. M. Swiatkowski, and G. R. Stark (2004)
PNAS 101, 192-197
   Abstract »    Full Text »    PDF »
Involvement of a Chaperone Regulator, Bcl2-associated Athanogene-4, in Apolipoprotein B mRNA Editing.
P. P. Lau and L. Chan (2003)
J. Biol. Chem. 278, 52988-52996
   Abstract »    Full Text »    PDF »
The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase.
T. H. Lee, Q. Huang, S. Oikemus, J. Shank, J.-J. Ventura, N. Cusson, R. R. Vaillancourt, B. Su, R. J. Davis, and M. A. Kelliher (2003)
Mol. Cell. Biol. 23, 8377-8385
   Abstract »    Full Text »    PDF »
Inositol 1,3,4-Trisphosphate 5/6-Kinase Inhibits Tumor Necrosis Factor-induced Apoptosis.
Y. Sun, Y. Mochizuki, and P. W. Majerus (2003)
J. Biol. Chem. 278, 43645-43653
   Abstract »    Full Text »    PDF »
TL1A-induced NF-{kappa}B Activation and c-IAP2 Production Prevent DR3-mediated Apoptosis in TF-1 Cells.
L. Wen, L. Zhuang, X. Luo, and P. Wei (2003)
J. Biol. Chem. 278, 39251-39258
   Abstract »    Full Text »    PDF »
Apparently Normal Tumor Necrosis Factor Receptor 1 Signaling in the Absence of the Silencer of Death Domains.
R. Endres, G. Hacker, I. Brosch, and K. Pfeffer (2003)
Mol. Cell. Biol. 23, 6609-6617
   Abstract »    Full Text »    PDF »
Expression of Silencer of Death Domains and Death-Receptor-3 in Normal Human Kidney and in Rejecting Renal Transplants.
R. S. Al-Lamki, J. Wang, S. Thiru, N. R. Pritchard, J. A. Bradley, J. S. Pober, and J. R. Bradley (2003)
Am. J. Pathol. 163, 401-411
   Abstract »    Full Text »    PDF »
RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-{alpha} and Lymphotoxin-{beta} Receptor Activation: CRITICAL ROLES FOR p100.
E. Derudder, E. Dejardin, L. L. Pritchard, D. R. Green, M. Korner, and V. Baud (2003)
J. Biol. Chem. 278, 23278-23284
   Abstract »    Full Text »    PDF »
Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Sensitizes Macrophages to Lipopolysaccharide-induced Nuclear Factor-{kappa}B, Mitogen-activated Protein Kinases, and Apoptosis.
Y. Takada and B. B. Aggarwal (2003)
J. Biol. Chem. 278, 23390-23397
   Abstract »    Full Text »    PDF »
Role of SODD in Regulation of Tumor Necrosis Factor Responses.
H. Takada, N.-J. Chen, C. Mirtsos, S. Suzuki, N. Suzuki, A. Wakeham, T. W. Mak, and W.-C. Yeh (2003)
Mol. Cell. Biol. 23, 4026-4033
   Abstract »    Full Text »    PDF »
Why Target Apoptosis in Cancer Treatment?.
S. Kasibhatla and B. Tseng (2003)
Mol. Cancer Ther. 2, 573-580
   Abstract »    Full Text »    PDF »
Etk/Bmx as a Tumor Necrosis Factor Receptor Type 2-Specific Kinase: Role in Endothelial Cell Migration and Angiogenesis.
S. Pan, P. An, R. Zhang, X. He, G. Yin, and W. Min (2002)
Mol. Cell. Biol. 22, 7512-7523
   Abstract »    Full Text »    PDF »
Molecular and Functional Interaction of the ATP-binding Cassette Transporter A1 with Fas-associated Death Domain Protein.
C. Buechler, S. M. Bared, C. Aslanidis, M. Ritter, W. Drobnik, and G. Schmitz (2002)
J. Biol. Chem. 277, 41307-41310
   Abstract »    Full Text »    PDF »
Interferon-{gamma} Augments CD95(APO-1/Fas) and Pro-Caspase-8 Expression and Sensitizes Human Vascular Endothelial Cells to CD95-Mediated Apoptosis.
J. H. Li, M. S. Kluger, L. A. Madge, L. Zheng, A. L. M. Bothwell, and J. S. Pober (2002)
Am. J. Pathol. 161, 1485-1495
   Abstract »    Full Text »    PDF »
BAG4/SODD Protein Contains a Short BAG Domain.
K. Briknarova, S. Takayama, S. Homma, K. Baker, E. Cabezas, D. W. Hoyt, Z. Li, A. C. Satterthwait, and K. R. Ely (2002)
J. Biol. Chem. 277, 31172-31178
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Receptor 1 Is an ATPase Regulated by Silencer of Death Domain.
K. Miki and E. M. Eddy (2002)
Mol. Cell. Biol. 22, 2536-2543
   Abstract »    Full Text »    PDF »
Restricted Localization of the TNF Receptor CD120a to Lipid Rafts: A Novel Role for the Death Domain.
V. Cottin, J. E. S. Doan, and D. W. H. Riches (2002)
J. Immunol. 168, 4095-4102
   Abstract »    Full Text »    PDF »
The Bile Acid Glycochenodeoxycholate Induces TRAIL-Receptor 2/DR5 Expression and Apoptosis.
H. Higuchi, S. F. Bronk, Y. Takikawa, N. Werneburg, R. Takimoto, W. El-Deiry, and G. J. Gores (2001)
J. Biol. Chem. 276, 38610-38618
   Abstract »    Full Text »    PDF »
NF-{kappa}B signaling pathways in mammalian and insect innate immunity.
N. Silverman and T. Maniatis (2001)
Genes & Dev. 15, 2321-2342
   Full Text »    PDF »
FGF Induces a Switch in Death Receptor Pathways in Neuronal Cells.
E. M. Eves, C. Skoczylas, K. Yoshida, E. S. Alnemri, and M. R. Rosner (2001)
J. Neurosci. 21, 4996-5006
   Abstract »    Full Text »    PDF »
TNF receptor I is required for induction of macrophage heat shock protein 70.
J. K. Heimbach, L. L. Reznikov, C. M. Calkins, T. N. Robinson, C. A. Dinarello, A. H. Harken, and X. Meng (2001)
Am J Physiol Cell Physiol 281, C241-C247
   Abstract »    Full Text »    PDF »
Soluble Decoy Receptor 3 Is Expressed by Malignant Gliomas and Suppresses CD95 Ligand-induced Apoptosis and Chemotaxis.
W. Roth, S. Isenmann, M. Nakamura, M. Platten, W. Wick, P. Kleihues, M. Bähr, H. Ohgaki, A. Ashkenazi, and M. Weller (2001)
Cancer Res. 61, 2759-2765
   Abstract »    Full Text »
Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis.
A. Hennino, M. Berard, P. H. Krammer, and T. Defrance (2001)
J. Exp. Med. 193, 447-458
   Abstract »    Full Text »    PDF »
Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.
M. Bibel and Y.-A. Barde (2000)
Genes & Dev. 14, 2919-2937
   Full Text »
Mechanisms of Apoptosis.
J. C. Reed (2000)
Am. J. Pathol. 157, 1415-1430
   Abstract »    Full Text »    PDF »
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B.
B. B Aggarwal (2000)
Ann Rheum Dis 59, i6-16
   Abstract »    Full Text »    PDF »
Metabolic Inhibitors Sensitize for CD95 (APO-1/Fas)-induced Apoptosis by Down-Regulating Fas-associated Death Domain-like Interleukin 1-Converting Enzyme Inhibitory Protein Expression.
S. Fulda, E. Meyer, and K.-M. Debatin (2000)
Cancer Res. 60, 3947-3956
   Abstract »    Full Text »
A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling.
F. K.-M. Chan, H. J. Chun, L. Zheng, R. M. Siegel, K. L. Bui, and M. J. Lenardo (2000)
Science 288, 2351-2354
   Abstract »    Full Text »
Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas.
T. Sodeman, S. F. Bronk, P. J. Roberts, H. Miyoshi, and G. J. Gores (2000)
Am J Physiol Gastrointest Liver Physiol 278, G992-G999
   Abstract »    Full Text »    PDF »
Discrete Signaling Regions in the Lymphotoxin-beta Receptor for Tumor Necrosis Factor Receptor-associated Factor Binding, Subcellular Localization, and Activation of Cell Death and NF-kappa B Pathways.
W. R. Force, A. A. Glass, C. A. Benedict, T. C. Cheung, J. Lama, and C. F. Ware (2000)
J. Biol. Chem. 275, 11121-11129
   Abstract »    Full Text »    PDF »
Phosphorylation of the Membrane Proximal Region of Tumor Necrosis Factor Receptor CD120a (p55) at ERK Consensus Sites.
A. A. Van Linden, V. Cottin, C. Leu, and D. W. H. Riches (2000)
J. Biol. Chem. 275, 6996-7003
   Abstract »    Full Text »    PDF »
Specific Chaperone-like Activity of Inhibitor of Caspase-activated DNase for Caspase-activated DNase.
H. Sakahira, A. Iwamatsu, and S. Nagata (2000)
J. Biol. Chem. 275, 8091-8096
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor (TNF)-{alpha} and TNF Receptors in Viral Pathogenesis.
G. Herbein and W. A. O'brien (2000)
Experimental Biology and Medicine 223, 241-257
   Abstract »    Full Text »
Programmed cell death in the developing heart.
M. J.B van den Hoff, S. M van den Eijnde, S. Viragh, and A. F.M Moorman (2000)
Cardiovasc Res 45, 603-620
   Full Text »    PDF »
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-xL.
D. C. S. Huang, M. Hahne, M. Schroeter, K. Frei, A. Fontana, A. Villunger, K. Newton, J. Tschopp, and A. Strasser (1999)
PNAS 96, 14871-14876
   Abstract »    Full Text »    PDF »
12-O-tetradecanoylphorbol-13-acetate-induced Apoptosis Is Mediated by Tumor Necrosis Factor alpha in Human Monocytic U937 Cells.
Y. Takada, M. Hachiya, Y. Osawa, Y. Hasegawa, K. Ando, Y. Kobayashi, and M. Akashi (1999)
J. Biol. Chem. 274, 28286-28292
   Abstract »    Full Text »    PDF »
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis.
Y. Lin, A. Devin, Y. Rodriguez, and Z.-g. Liu (1999)
Genes & Dev. 13, 2514-2526
   Abstract »    Full Text »
A new mechanism of neurodegeneration: A proinflammatory cytokine inhibits receptor signaling by a survival peptide.
H. D. Venters, Q. Tang, Q. Liu, R. W. VanHoy, R. Dantzer, and K. W. Kelley (1999)
PNAS 96, 9879-9884
   Abstract »    Full Text »    PDF »
E1A Sensitizes Cells to Tumor Necrosis Factor-induced Apoptosis through Inhibition of Ikappa B Kinases and Nuclear Factor kappa B Activities.
R. Shao, M. C.-T. Hu, B. P. Zhou, S.-Y. Lin, P. J. Chiao, R. H. von Lindern, B. Spohn, and M.-C. Hung (1999)
J. Biol. Chem. 274, 21495-21498
   Abstract »    Full Text »    PDF »
Signal Transduction by Tumor Necrosis Factor: The Parker B. Francis Lectureship.
D. V. Goeddel (1999)
Chest 116 , 69S-73S
   Full Text »
NF-{kappa}B Activation by Tumor Necrosis Factor and Interleukin-1.
Z. CAO, M. TANAKA, C. REGNIER, M. ROTHE, A. YAMIT-HEZI, J.D. WORONICZ, M.E. FUENTES, M.H. DURNIN, S.A. DALRYMPLE, and D.V. GOEDDEL (1999)
Cold Spring Harb Symp Quant Biol 64, 473-484
   Abstract »    PDF »
Phosphatidylinositol 3-Kinase/Akt Activity Regulates c-FLIP Expression in Tumor Cells.
D. J. Panka, T. Mano, T. Suhara, K. Walsh, and J. W. Mier (2001)
J. Biol. Chem. 276, 6893-6896
   Abstract »    Full Text »    PDF »
Persistent Tumor Necrosis Factor Signaling in Normal Human Fibroblasts Prevents the Complete Resynthesis of Ikappa B-alpha.
D. M. Poppers, P. Schwenger, and J. Vilcek (2000)
J. Biol. Chem. 275, 29587-29593
   Abstract »    Full Text »    PDF »
Structure/Function Analysis of p55 Tumor Necrosis Factor Receptor and Fas-associated Death Domain. EFFECT ON NECROSIS IN L929sA CELLS.
E. Boone, T. Vanden Berghe, G. Van Loo, G. De Wilde, N. De Wael, D. Vercammen, W. Fiers, G. Haegeman, and P. Vandenabeele (2000)
J. Biol. Chem. 275, 37596-37603
   Abstract »    Full Text »    PDF »
A1 Functions at the Mitochondria to Delay Endothelial Apoptosis in Response to Tumor Necrosis Factor.
P. J. Duriez, F. Wong, K. Dorovini-Zis, R. Shahidi, and A. Karsan (2000)
J. Biol. Chem. 275, 18099-18107
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)