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Science 8 January 1999: Vol. 283. no. 5399, pp. 215 - 217 DOI: 10.1126/science.283.5399.215
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Reports
A Molecular Mechanism for Electrical Tuning of Cochlear Hair Cells
Krishnan Ramanathan,
Timothy H. Michael,
Guo-Jian Jiang,
Hakim Hiel,
Paul A. Fuchs
*
Cochlear frequency selectivity in lower vertebrates arises in part
from electrical tuning intrinsic to the sensory hair cells. The
resonant frequency is determined largely by the gating kinetics of
calcium-activated potassium (BK) channels encoded by the slo gene. Alternative splicing of slo from chick cochlea
generated kinetically distinct BK channels. Combination with accessory
subunits slowed the gating kinetics of splice variants but
preserved relative differences between them. In situ hybridization
showed that the subunit is preferentially expressed by
low-frequency (apical) hair cells in the avian cochlea. Interaction of
with splice variants could provide the kinetic range needed for
electrical tuning of cochlear hair cells.
K. Ramanathan, Center for Hearing Sciences, Department of
Biomedical Engineering, Johns Hopkins University School of Medicine,
Baltimore, MD 21205, USA. T. H. Michael, G.-J. Jiang, H. Hiel, Center for Hearing Sciences, Department of Otolaryngology-Head
and Neck Surgery (HNS), Johns Hopkins University School of Medicine,
Baltimore, MD 21205, USA. P. A. Fuchs, Center for Hearing
Sciences, Departments of Otolaryngology-HNS and Biomedical
Engineering, Johns Hopkins University School of Medicine, Baltimore, MD
21205, USA.
*
To whom correspondence should be addressed. E-mail:
pfuchs{at}bme.jhu.edu
Read the Full Text
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