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Science 18 December 1998:
Vol. 282. no. 5397, pp. 2202 - 2203
DOI: 10.1126/science.282.5397.2202
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Perspectives

PROTEIN STRUCTURE:
Pumping Iron Through Cell Membranes

Volkmar Braun

Despite their importance in various cellular functions, the three-dimensional structure at atomic resolution has been determined for only a few membrane proteins. In his Perspective, Braun discusses results reported in the same issue by Ferguson et al. in which the crystal structure of FhuA, an iron transporter protein, has been determined at high resolution. This and related proteins may be the general model for a large class of iron-transporting molecules.

The author is in the department of Mikrobiologie/Membranphysiologie, Universität Tüebingen, D-72076 Tübingen, Germany. E-mail: volkmar.braun{at}mikrobio.uni-tuebingen.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Ton System, an ABC Transporter, and a Universally Conserved GTPase Are Involved in Iron Utilization by Brucella melitensis 16M.
I. Danese, V. Haine, R.-M. Delrue, A. Tibor, P. Lestrate, O. Stevaux, P. Mertens, J.-Y. Paquet, J. Godfroid, X. De Bolle, et al. (2004)
Infect. Immun. 72, 5783-5790
   Abstract »    Full Text »    PDF »
TonB of Escherichia coli activates FhuA through interaction with the {beta}-barrel.
H. Killmann, C. Herrmann, A. Torun, G. Jung, and V. Braun (2002)
Microbiology 148, 3497-3509
   Abstract »    Full Text »    PDF »
Microbial iron transport via a siderophore shuttle: A membrane ion transport paradigm.
A. Stintzi, C. Barnes, J. Xu, and K. N. Raymond (2000)
PNAS
   Abstract »    Full Text »
An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis.
S. K. Mazmanian, H. Ton-That, K. Su, and O. Schneewind (2002)
PNAS 99, 2293-2298
   Abstract »    Full Text »    PDF »
Microbial iron transport via a siderophore shuttle: A membrane ion transport paradigm.
A. Stintzi, C. Barnes, J. Xu, and K. N. Raymond (2000)
PNAS 97, 10691-10696
   Abstract »    Full Text »    PDF »


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