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Science 18 December 1998:
Vol. 282. no. 5397, p. 2149
DOI: 10.1126/science.282.5397.2149l
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T cells become activated after they meet their antigen, but the most efficient and persistent signaling requires costimulation of a T cell needs through another receptor, such as CD28. Wülfing and Davis (p. 2266) determined that only when the T cell antigen receptor (TCR) of T cells binds antigen while simultaneously receiving a costimulatory signal, do other proteins that are linked to the actin cytoskeleton move to the TCR complex. This costimulation-dependent cellular reorganization relies upon myosin motors and may be a key component of the costimulatory effect.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)