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Science 11 December 1998:
Vol. 282. no. 5396, pp. 2022 - 2028
DOI: 10.1126/science.282.5396.2022
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Review

Comparison of the Complete Protein Sets of Worm and Yeast: Orthology and Divergence

Stephen A. Chervitz, L. Aravind, Gavin Sherlock, Catherine A. Ball, Eugene V. Koonin, Selina S. Dwight, Midori A. Harris, Kara Dolinski, Scott Mohr, Temple Smith, Shuai Weng, J. Michael Cherry, David Botstein

Comparative analysis of predicted protein sequences encoded by the genomes of Caenorhabditis elegans and Saccharomyces cerevisiae suggests that most of the core biological functions are carried out by orthologous proteins (proteins of different species that can be traced back to a common ancestor) that occur in comparable numbers. The specialized processes of signal transduction and regulatory control that are unique to the multicellular worm appear to use novel proteins, many of which re-use conserved domains. Major expansion of the number of some of these domains seen in the worm may have contributed to the advent of multicellularity. The proteins conserved in yeast and worm are likely to have orthologs throughout eukaryotes; in contrast, the proteins unique to the worm may well define metazoans.

S. A. Chervitz, G. Sherlock, C. A. Ball, S. S. Dwight, M. A. Harris, K. Dolinski, S. Weng, J. M. Cherry, and D. Botstein are in the Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA. L. Aravind and E. V. Koonin are at the National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. S. Mohr and T. Smith are in the Department of Biomedical Engineering, Boston University, Boston, MA 02115, USA.

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