Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 4 December 1998:
Vol. 282. no. 5395, pp. 1882 - 1884
DOI: 10.1126/science.282.5395.1882
Prev | Table of Contents | Next

Reports

Frequency Tuning of Basilar Membrane and Auditory Nerve Fibers in the Same Cochleae

S. Shyamla Narayan, Andrei N. Temchin, Alberto Recio, Mario A. Ruggero *

Responses to tones of a basilar membrane site and of auditory nerve fibers innervating neighboring inner hair cells were recorded in the same cochleae in chinchillas. At near-threshold stimulus levels, the frequency tuning of auditory nerve fibers closely paralleled that of basilar membrane displacement modified by high-pass filtering, indicating that only relatively minor signal transformations intervene between mechanical vibration and auditory nerve excitation. This finding establishes that cochlear frequency selectivity in chinchillas (and probably in mammals in general) is fully expressed in the vibrations of the basilar membrane and renders unnecessary additional ("second") filters, such as those present in the hair cells of the cochleae of reptiles.

S. S. Narayan, A. N. Temchin, M. A. Ruggero, The Hugh Knowles Center, Audiology and Hearing Sciences Program, Department of Communication Sciences and Disorders, and Institute for Neuroscience, Northwestern University, Evanston, IL 60208-3550, USA. A. Recio, Department of Physiology, University of Wisconsin, Madison, WI 53706, USA.
*   To whom correspondence should be addressed. E-mail: mruggero{at}nwu.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Development of Cochlear Amplification, Frequency Tuning, and Two-Tone Suppression in the Mouse.
L. Song, J. McGee, and E. J. Walsh (2008)
J Neurophysiol 99, 344-355
   Abstract »    Full Text »    PDF »
Cochlear Outer Hair Cell Motility.
J. Ashmore (2008)
Physiol Rev 88, 173-210
   Abstract »    Full Text »    PDF »
Spatial Interaction Between Spectral Integration and Frequency Gradient in Primary Auditory Cortex.
K. Imaizumi and C. E. Schreiner (2007)
J Neurophysiol 98, 2933-2942
   Abstract »    Full Text »    PDF »
Wiener-Kernel Analysis of Responses to Noise of Chinchilla Auditory-Nerve Fibers.
A. Recio-Spinoso, A. N. Temchin, P. van Dijk, Y.-H. Fan, and M. A. Ruggero (2005)
J Neurophysiol 93, 3615-3634
   Abstract »    Full Text »    PDF »
Wiener Kernels of Chinchilla Auditory-Nerve Fibers: Verification Using Responses to Tones, Clicks, and Noise and Comparison With Basilar-Membrane Vibrations.
A. N. Temchin, A. Recio-Spinoso, P. van Dijk, and M. A. Ruggero (2005)
J Neurophysiol 93, 3635-3648
   Abstract »    Full Text »    PDF »
Cochlear function in Prestin knockout mice.
M. A Cheatham, K. H Huynh, J Gao, J Zuo, and P Dallos (2004)
J. Physiol. 560, 821-830
   Abstract »    Full Text »    PDF »
A unifying basis of auditory thresholds based on temporal summation.
P. Heil and H. Neubauer (2003)
PNAS 100, 6151-6156
   Abstract »    Full Text »    PDF »
Longitudinal pattern of basilar membrane vibration in the sensitive cochlea.
T. Ren (2002)
PNAS 99, 17101-17106
   Abstract »    Full Text »    PDF »
The roles of the external, middle, and inner ears in determining the bandwidth of hearing.
M. A. Ruggero and A. N. Temchin (2002)
PNAS 99, 13206-13210
   Abstract »    Full Text »    PDF »
Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements.
C. A. Shera, J. J. Guinan Jr., and A. J. Oxenham (2002)
PNAS
   Abstract »    Full Text »    PDF »
Compressive nonlinearity in the hair bundle's active response to mechanical stimulation.
P. Martin and A. J. Hudspeth (2001)
PNAS
   Abstract »    Full Text »    PDF »
Temporal Integration of Sound Pressure Determines Thresholds of Auditory-Nerve Fibers.
P. Heil and H. Neubauer (2001)
J. Neurosci. 21, 7404-7415
   Abstract »    Full Text »    PDF »
Mechanics of the Mammalian Cochlea.
L. Robles and M. A. Ruggero (2001)
Physiol Rev 81, 1305-1352
   Abstract »    Full Text »    PDF »
Mechanical bases of frequency tuning and neural excitation at the base of the cochlea: Comparison of basilar-membrane vibrations and auditory-nerve-fiber responses in chinchilla.
M. A. Ruggero, S. S. Narayan, A. N. Temchin, and A. Recio (2000)
PNAS 97, 11744-11750
   Abstract »    Full Text »    PDF »
Regional Distribution of Ionic Currents and Membrane Voltage Responses of Type II Hair Cells in the Vestibular Neuroepithelium.
T. Weng and M. J. Correia (1999)
J Neurophysiol 82, 2451-2461
   Abstract »    Full Text »    PDF »
Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements.
C. A. Shera, J. J. Guinan Jr., and A. J. Oxenham (2002)
PNAS 99, 3318-3323
   Abstract »    Full Text »    PDF »
Compressive nonlinearity in the hair bundle's active response to mechanical stimulation.
P. Martin and A. J. Hudspeth (2001)
PNAS 98, 14386-14391
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)