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Science 4 December 1998:
Vol. 282. no. 5395, p. 1781
DOI: 10.1126/science.282.5395.1781i
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Members of the mitogen-activated protein kinase (MAPK) family are activated by cascades of protein kinases that begin with the MAPK kinase kinases (MAPKKKs). The MAPKKK called MEKK1 can lead to activation of two different sorts of MAPKs known as JNK and ERK, but it has been unclear what its physiological targets are in vivo. Yujiri et al. (p. 1911) produced mice that do not express the MEKK1 protein and showed that coupling of MEKK1 to specific MAPKs was highly dependent on the type of external stress. For example, activation of JNK in response to cold stress or serum factors was lost, but not the responses to ultraviolet radiation or heat shock. In some cases, MEKK1 contributed to activation of ERK, but other stimuli that activated MEKK1 resulted only in activation of JNK.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)