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Science 27 November 1998:
Vol. 282. no. 5394, pp. 1705 - 1708
DOI: 10.1126/science.282.5394.1705
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Reports

Regulation of Nerve Growth Mediated by Inositol 1,4,5-Trisphosphate Receptors in Growth Cones

Kohtaro Takei, * Ryong-Moon Shin, Takafumi Inoue, Kunio Kato, Katsuhiko Mikoshiba

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) acts as a Ca2+ release channel on internal Ca2+ stores. Type 1 IP3R (IP3R1) is enriched in growth cones of neurons in chick dorsal root ganglia. Depletion of internal Ca2+ stores and inhibition of IP3 signaling with drugs inhibited neurite extension. Microinjection of heparin, a competitive IP3R blocker, induced neurite retraction. Acute localized loss of function of IP3R1 in the growth cone induced by chromophore-assisted laser inactivation resulted in growth arrest and neurite retraction. IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth.

K. Takei and K. Kato, Calciosignal Net Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Corporation (JST), Bunkyo-Ku, Tokyo 113-0021, Japan. R.-M. Shin and T. Inoue, Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Minato-Ku, Tokyo 108-0071, Japan. K. Mikoshiba, Calciosignal Net Project, ERATO, JST, Bunkyo-Ku, Tokyo 113-0021, Japan, Department of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Minato-Ku, Tokyo 108-0071, Japan, and Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.
*   To whom correspondence should be addressed. E-mail: kohtaro{at}ims.u-tokyo.ac.jp

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Science. ISSN 0036-8075 (print), 1095-9203 (online)