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Science 6 November 1998:
Vol. 282. no. 5391, pp. 1062 - 1063
DOI: 10.1126/science.282.5391.1062
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Perspectives

NEUROSCIENCE:
Long-Term Change of Mind

Michael Merzenich

Loss of a limb can cause profound changes in the life of the victim. No less important is a massive reorganization of the brain that accompanies such injuries. Now two papers report the details of such neural changes in two groups of monkeys with somewhat different deficits, and Merzenich reconciles the different results in his Perspective.

The author is at the Keck Center for Integrative Neurosciences, University of California, San Francisco, CA 94143-0732, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Preserved Responsiveness of Secondary Somatosensory Cortex in Patients with Thalamic Stroke.
B. Taskin, G. J. Jungehulsing, J. Ruben, P. Brunecker, T. Krause, F. Blankenburg, and A. Villringer (2006)
Cereb Cortex 16, 1431-1439
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Topographic Plasticity in Primary Visual Cortex Is Mediated by Local Corticocortical Connections.
M. B. Calford, L. L. Wright, A. B. Metha, and V. Taglianetti (2003)
J. Neurosci. 23, 6434-6442
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Epigenetic Downregulation of GABAergic Function in Schizophrenia: Potential for Pharmacological Intervention?.
E. Costa, D. R. Grayson, and A. Guidotti (2003)
Mol. Interv. 3, 220-229
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Reorganization in Awake Rat Auditory Cortex by Local Microstimulation and Its Effect on Frequency-Discrimination Behavior.
S. K. Talwar and G. L. Gerstein (2001)
J Neurophysiol 86, 1555-1572
   Abstract »    Full Text »    PDF »
Loss of Synaptic Depression in Mammalian Anterior Cingulate Cortex after Amputation.
F. Wei, P. Li, and M. Zhuo (1999)
J. Neurosci. 19, 9346-9354
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)