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Science 30 October 1998:
Vol. 282. no. 5390, pp. 941 - 943
DOI: 10.1126/science.282.5390.941
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Reports

TNF-alpha Induction of CD44-Mediated Leukocyte Adhesion by Sulfation

Arpita Maiti, Guitta Maki, * Pauline Johnson dagger

Regulation of cell adhesion is important for immune system function. CD44 is a tightly regulated cell adhesion molecule present on leukocytes and implicated in their attachment to endothelium during an inflammatory immune response. The proinflammatory cytokine tumor necrosis factor-alpha , but not interferon-gamma , was found to convert CD44 from its inactive, nonbinding form to its active form by inducing the sulfation of CD44. This posttranslational modification was required for CD44-mediated binding to the extracellular matrix component hyaluronan and to vascular endothelial cells. Sulfation is thus a potential means of regulating CD44-mediated leukocyte adhesion at inflammatory sites.

A. Maiti and P. Johnson, Department of Microbiology and Immunology, University of British Columbia, 300-6174 University Boulevard, Vancouver, B.C. V6T 1Z3, Canada. G. Maki, Terry Fox Laboratories, 601 West 10th Avenue, Vancouver, B.C. V5Z 1L3, Canada.
*   Present address: Section of Bone Marrow Transplantation, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.

dagger    To whom correspondence should be addressed. E-mail: pauline{at}unixg.ubc.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)