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Science 30 October 1998:
Vol. 282. no. 5390, pp. 938 - 941
DOI: 10.1126/science.282.5390.938
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Reports

Binding of Hepatitis C Virus to CD81

Piero Pileri, * Yasushi Uematsu, * Susanna Campagnoli, Giuliano Galli, Fabiana Falugi, Roberto Petracca, Amy J. Weiner, Michael Houghton, Domenico Rosa, Guido Grandi, Sergio Abrignani dagger

Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B lymphocyte proliferative disorder. Virus tropism is controversial, and the mechanisms of cell entry remain unknown. The HCV envelope protein E2 binds human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes. Binding of E2 was mapped to the major extracellular loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.

P. Pileri, Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi, R. Petracca, D. Rosa, G. Grandi, S. Abrignani, IRIS, Chiron, Siena 53100, Italy. A. J. Weiner and M. Houghton, Chiron Corporation, Emeryville, CA 94608, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: abrignani{at}iris02.biocine.it

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J. Virol. 79, 10839-10851
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Monoclonal Antibody AP33 Defines a Broadly Neutralizing Epitope on the Hepatitis C Virus E2 Envelope Glycoprotein.
A. Owsianka, A. W. Tarr, V. S. Juttla, D. Lavillette, B. Bartosch, F.-L. Cosset, J. K. Ball, and A. H. Patel (2005)
J. Virol. 79, 11095-11104
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Protein-Protein Interactions in the Tetraspanin Web.
S. Levy and T. Shoham (2005)
Physiology 20, 218-224
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Complete Replication of Hepatitis C Virus in Cell Culture.
B. D. Lindenbach, M. J. Evans, A. J. Syder, B. Wolk, T. L. Tellinghuisen, C. C. Liu, T. Maruyama, R. O. Hynes, D. R. Burton, J. A. McKeating, et al. (2005)
Science 309, 623-626
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Compartmentalization of Hepatitis C Virus Quasispecies in Blood Mononuclear Cells of Patients with Mixed Cryoglobulinemic Syndrome.
G. Zehender, C. De Maddalena, F. Bernini, E. Ebranati, G. Monti, P. Pioltelli, and M. Galli (2005)
J. Virol. 79, 9145-9156
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Efficient hepatitis C virus cell culture system: What a difference the host cell makes.
R. Bartenschlager and T. Pietschmann (2005)
PNAS 102, 9739-9740
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Hepatitis C Virus E2-CD81 Interaction Induces Hypermutation of the Immunoglobulin Gene in B Cells.
K. Machida, K. T.-H. Cheng, N. Pavio, V. M.-H. Sung, and M. M. C. Lai (2005)
J. Virol. 79, 8079-8089
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An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies.
B. Bartosch, G. Verney, M. Dreux, P. Donot, Y. Morice, F. Penin, J.-M. Pawlotsky, D. Lavillette, and F.-L. Cosset (2005)
J. Virol. 79, 8217-8229
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