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Science 16 October 1998:
Vol. 282. no. 5388, pp. 480 - 483
DOI: 10.1126/science.282.5388.480
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Reports

Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking

Gwendalyn J. Randolph, * Sylvie Beaulieu, Serge Lebecque, Ralph M. Steinman, William A. Muller

Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in subendothelial collagen. These nascent dendritic cells migrated across the endothelium in the ablumenal-to-lumenal direction, as would occur during entry into lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration.

G. J. Randolph and W. A. Muller, Department of Pathology, Cornell University Medical College, 1300 York Avenue, Room C-420, New York, NY 10021, USA. S. Beaulieu and R. M. Steinman, Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA. S. Lebecque, Laboratory for Immunological Research, Schering-Plough, 69571 Dardilly, France.
*   To whom correspondence should be addressed. E-mail: GJRandol{at}mail.med.cornell.edu

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Lipopolysaccharide or Whole Bacteria Block the Conversion of Inflammatory Monocytes into Dendritic Cells In Vivo.
G. Rotta, E. W. Edwards, S. Sangaletti, C. Bennett, S. Ronzoni, M. P. Colombo, R. M. Steinman, G. J. Randolph, and M. Rescigno (2003)
J. Exp. Med. 198, 1253-1263
   Abstract »    Full Text »    PDF »
Dendritic cells in the arterial wall express C1q: potential significance in atherogenesis.
W. Cao, Y. V Bobryshev, R. S.A Lord, R. E.I Oakley, S. H Lee, and J. Lu (2003)
Cardiovasc Res 60, 175-186
   Abstract »    Full Text »    PDF »
IFN-{alpha} Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities.
M. Mohty, A. Vialle-Castellano, J. A. Nunes, D. Isnardon, D. Olive, and B. Gaugler (2003)
J. Immunol. 171, 3385-3393
   Abstract »    Full Text »    PDF »
T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells.
H. Q. Shen, M. Lu, T. Ikawa, K. Masuda, K. Ohmura, N. Minato, Y. Katsura, and H. Kawamoto (2003)
J. Immunol. 171, 3401-3406
   Abstract »    Full Text »    PDF »
TNF Skews Monocyte Differentiation from Macrophages to Dendritic Cells.
P. Chomarat, C. Dantin, L. Bennett, J. Banchereau, and A. K. Palucka (2003)
J. Immunol. 171, 2262-2269
   Abstract »    Full Text »    PDF »
Anaphylatoxin C5a Induces Monocyte Recruitment and Differentiation into Dendritic Cells by TNF-{alpha} and Prostaglandin E2-Dependent Mechanisms.
A. Soruri, J. Riggert, T. Schlott, Z. Kiafard, C. Dettmer, and J. Zwirner (2003)
J. Immunol. 171, 2631-2636
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor-{alpha} Promotes Macrophage-Induced Vascular Smooth Muscle Cell Apoptosis by Direct and Autocrine Mechanisms.
J. J. Boyle, P. L. Weissberg, and M. R. Bennett (2003)
Arterioscler Thromb Vasc Biol 23, 1553-1558
   Abstract »    Full Text »    PDF »
P-Selectin Enhances Generation of CD14+CD16+ Dendritic-Like Cells and Inhibits Macrophage Maturation from Human Peripheral Blood Monocytes.
G. Li, Y.-J. Kim, C. Mantel, and H. E. Broxmeyer (2003)
J. Immunol. 171, 669-677
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ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling.
M. Schnurr, T. Toy, P. Stoitzner, P. Cameron, A. Shin, T. Beecroft, I. D. Davis, J. Cebon, and E. Maraskovsky (2003)
Blood 102, 613-620
   Abstract »    Full Text »    PDF »
Differentiation of Monocytic Cell Clones into CD8{alpha}+ Dendritic Cells (DC) Suggests that Monocytes Can Be Direct Precursors for Both CD8{alpha}+ and CD8{alpha}- DC in the Mouse.
J.-X. Gao, X. Liu, J. Wen, H. Zhang, J. Durbin, Y. Liu, and P. Zheng (2003)
J. Immunol. 170, 5927-5935
   Abstract »    Full Text »    PDF »
Interleukin-10 Therapy--Review of a New Approach.
K. Asadullah, W. Sterry, and H. D. Volk (2003)
Pharmacol. Rev. 55, 241-269
   Abstract »    Full Text »    PDF »
Nondisposable materials, chronic inflammation, and adjuvant action.
J. A. Hamilton (2003)
J. Leukoc. Biol. 73, 702-712
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Prostaglandin D2 Affects the Maturation of Human Monocyte-Derived Dendritic Cells: Consequence on the Polarization of Naive Th Cells.
P. Gosset, F. Bureau, V. Angeli, M. Pichavant, C. Faveeuw, A.-B. Tonnel, and F. Trottein (2003)
J. Immunol. 170, 4943-4952
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Mature Dendritic Cells Derived from Human Monocytes Within 48 Hours: A Novel Strategy for Dendritic Cell Differentiation from Blood Precursors.
M. Dauer, B. Obermaier, J. Herten, C. Haerle, K. Pohl, S. Rothenfusser, M. Schnurr, S. Endres, and A. Eigler (2003)
J. Immunol. 170, 4069-4076
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CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions.
J Plumb, M A Armstrong, M Duddy, M Mirakhur, and S McQuaid (2003)
Multiple Sclerosis 9, 142-147
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