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Science 18 September 1998:
Vol. 281. no. 5384, pp. 1774 - 1775
DOI: 10.1126/science.281.5384.1774
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News of the Week

HUMAN GENOME PROJECT:
NIH to Produce a 'Working Draft' of the Genome by 2001

Eliot Marshall

Faced with growing competition from private companies, such as a new venture formed by DNA sequencer J. Craig Venter and the Perkin-Elmer Corp., the U.S. National Human Genome Research Institute (NHGRI) unveiled a 5-year plan this week that promises to produce a "working draft" of the human genome--including highly accurate sequences of most of the protein-coding regions--by 2001. The plan also promises to yield a polished, gold-standard version of the entire genome by 2003, 2 years ahead of the old schedule. If successful, this radical change of plan will not only speed up the pace at government-funded labs but also, according to some of NHGRI's advisers, release data so rapidly that companies like Perkin-Elmer may not be able to get exclusive rights to all the DNA they hoped to patent.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Toxicogenomics-Based Discrimination of Toxic Mechanism in HepG2 Human Hepatoma Cells.
M. E. Burczynski, M. McMillian, J. Ciervo, L. Li, J. B. Parker, R. T. Dunn II, S. Hicken, S. Farr, and M. D. Johnson (2000)
Toxicol. Sci. 58, 399-415
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Sequence-tagged connectors: A sequence approach to mapping and scanning the human genome.
G. G. Mahairas, J. C. Wallace, K. Smith, S. Swartzell, T. Holzman, A. Keller, R. Shaker, J. Furlong, J. Young, S. Zhao, et al. (1999)
PNAS 96, 9739-9744
   Abstract »    Full Text »    PDF »
AMPD1 Gene Mutation in Congestive Heart Failure : New Insights Into the Pathobiology of Disease Progression.
A. M. Feldman, D. R. Wagner, and D. M. McNamara (1999)
Circulation 99, 1397-1399
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Toward a Complete Human Genome Sequence.
T. S. Centre and T. W. U. G. S. Center (1998)
Genome Res. 8, 1097-1108
   Abstract »    Full Text »


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