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Science 18 September 1998:
Vol. 281. no. 5384, p. 1765
DOI: 10.1126/science.281.5384.1765m
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Neurons respond to synaptic activity not only by forwarding the electrical signal but also by rearranging their growth to adapt to developing or changing signaling regimes. CPG15, a protein identified in the rat and Xenopus laevis, is induced in response to synaptic activity. Nedivi et al. (p. 1863) show by overexpressing the protein that it promotes growth of dendrites in projection neurons but has no effect on interneurons. The CPG15 protein appears to function in an intercellular signaling mechanism.




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