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Science 11 September 1998:
Vol. 281. no. 5383, pp. 1671 - 1674
DOI: 10.1126/science.281.5383.1671
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Reports

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Alan J. Whitmarsh, Julie Cavanagh, Cathy Tournier, Jun Yasuda, Roger J. Davis *

The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School and Howard Hughes Medical Institute, Worcester, MA 01605, USA.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic {beta} cells.
J.-A. Haefliger, T. Tawadros, L. Meylan, S. L. Gurun, M.-E. Roehrich, D. Martin, B. Thorens, and G. Waeber (2003)
J. Cell Sci. 116, 1463-1469
   Abstract »    Full Text »    PDF »
Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress.
K. J. Cowan and K. B. Storey (2003)
J. Exp. Biol. 206, 1107-1115
   Abstract »    Full Text »    PDF »
The JNK-interacting Protein-1 Scaffold Protein Targets MAPK Phosphatase-7 to Dephosphorylate JNK.
E. A. Willoughby, G. R. Perkins, M. K. Collins, and A. J. Whitmarsh (2003)
J. Biol. Chem. 278, 10731-10736
   Abstract »    Full Text »    PDF »
JNK-interacting protein-1 promotes transcription of Abeta protein precursor but not Abeta precursor-like proteins, mechanistically different than Fe65.
M. H. Scheinfeld, S. Matsuda, and L. D'Adamio (2003)
PNAS 100, 1729-1734
   Abstract »    Full Text »    PDF »
c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade.
Y. H. Lee, J. Giraud, R. J. Davis, and M. F. White (2003)
J. Biol. Chem. 278, 2896-2902
   Abstract »    Full Text »    PDF »
Cutting Edge: Induced Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, Following CD40 Stimulation and WEHI 231 B Cell Activation.
J. R. Lee, Y. J. Ha, and H. J. Kim (2003)
J. Immunol. 170, 19-23
   Abstract »    Full Text »    PDF »
C-Jun NH2-terminal Kinase Mediates Proliferation and Tumor Growth of Human Prostate Carcinoma.
Y.-M. Yang, F. Bost, W. Charbono, N. Dean, R. McKay, J. S. Rhim, C. Depatie, and D. Mercola (2003)
Clin. Cancer Res. 9, 391-401
   Abstract »    Full Text »    PDF »
A New Identity for MLK3 as an NIMA-related, Cell Cycle-regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization.
K. I. Swenson, K. E. Winkler, and A. R. Means (2003)
Mol. Biol. Cell 14, 156-172
   Abstract »    Full Text »
ATF1 Phosphorylation by the ERK MAPK Pathway Is Required for Epidermal Growth Factor-induced c-jun Expression.
P. Gupta and R. Prywes (2002)
J. Biol. Chem. 277, 50550-50556
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Fibroblast Growth Factor Homologous Factors and the Islet Brain-2 Scaffold Protein Regulate Activation of a Stress-activated Protein Kinase.
J. Schoorlemmer and M. Goldfarb (2002)
J. Biol. Chem. 277, 49111-49119
   Abstract »    Full Text »    PDF »
CD44 is required for two consecutive steps in HGF/c-Met signaling.
V. Orian-Rousseau, L. Chen, J. P. Sleeman, P. Herrlich, and H. Ponta (2002)
Genes & Dev. 16, 3074-3086
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Phosphorylation-dependent Scaffolding Role of JSAP1/JIP3 in the ASK1-JNK Signaling Pathway. A NEW MODE OF REGULATION OF THE MAP KINASE CASCADE.
H. Matsuura, H. Nishitoh, K. Takeda, A. Matsuzawa, T. Amagasa, M. Ito, K. Yoshioka, and H. Ichijo (2002)
J. Biol. Chem. 277, 40703-40709
   Abstract »    Full Text »    PDF »
A Novel Specific Role for Ikappa B Kinase Complex-associated Protein in Cytosolic Stress Signaling.
C. Holmberg, S. Katz, M. Lerdrup, T. Herdegen, M. Jaattela, A. Aronheim, and T. Kallunki (2002)
J. Biol. Chem. 277, 31918-31928
   Abstract »    Full Text »    PDF »
Activation of p38alpha MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization.
N. Reunanen, S.-P. Li, M. Ahonen, M. Foschi, J. Han, and V.-M. Kahari (2002)
J. Biol. Chem. 277, 32360-32368
   Abstract »    Full Text »    PDF »


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