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Science 4 September 1998:
Vol. 281. no. 5382, pp. 1515 - 1518
DOI: 10.1126/science.281.5382.1515
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Reports

Conversion of Neuronal Growth Cone Responses from Repulsion to Attraction by Cyclic Nucleotides

Hong-jun Song, * Guo-li Ming, * Zhigang He, * Maxime Lehmann, Lisa McKerracher, Marc Tessier-Lavigne, Mu-ming Poo dagger

Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured Xenopus spinal neurons; the repulsion can be converted to attraction by pharmacological activation of the guanosine 3',5'-monophosphate (cGMP) and adenosine 3',5'-monophosphate signaling pathways, respectively. Sema III also causes the collapse of cultured rat sensory growth cones, which can be inhibited by activation of the cGMP pathway. Thus cyclic nucleotides can regulate growth cone behaviors and may be targets for designing treatments to alleviate the inhibition of nerve regeneration by repulsive factors.

H-j. Song, G-l. Ming, M-m. Poo, Department of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA. Z. He and M. Tessier-Lavigne, Howard Hughes Medical Institute, Department of Anatomy and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA 94143-0452, USA. M. Lehmann and L. McKerracher, Departement de Pathologie, Université de Montreal, and McGill University, C.P. 6128, Succursale Centre-ville Montreal, Quebec H3C 3J7, Canada.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: mpoo{at}ucsd.edu

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