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Science 4 September 1998:
Vol. 281. no. 5382, pp. 1466 - 1467
DOI: 10.1126/science.281.5382.1466
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

NUCLEAR STRUCTURE:
Enhanced: Duplicating a Tangled Genome

Peter Cook

Each cell's genetic material--long, long strands of DNA--is packed into the small sphere of the nucleus. In his Perspective, Cook describes what we know about how the cell does this packing while still allowing the cell to transcribe genes and replicate DNA. He goes on to discuss new results in this issue by Wei et al. that identify separate transcription and replication zones in the nuclei of cells.

The author is in the Department of Cell Biology, Sir William Dunn School of Pathology, South Parks Road, Oxford OX2 3RE, UK. E-mail: peter.cook{at}path.ox.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.
Q. Hu, Y.-S. Kwon, E. Nunez, M. D. Cardamone, K. R. Hutt, K. A. Ohgi, I. Garcia-Bassets, D. W. Rose, C. K. Glass, M. G. Rosenfeld, et al. (2008)
PNAS 105, 19199-19204
   Abstract »    Full Text »    PDF »
Macroscopic folding and replication of the homogeneously staining region in late S phase leads to the appearance of replication bands in mitotic chromosomes.
N. Shimizu and K. Shingaki (2004)
J. Cell Sci. 117, 5303-5312
   Abstract »    Full Text »    PDF »
Making Sense of Eukaryotic DNA Replication Origins.
D. M. Gilbert (2001)
Science 294, 96-100
   Abstract »    Full Text »    PDF »
Crystal Structure of the Nuclear Matrix Targeting Signal of the Transcription Factor Acute Myelogenous Leukemia-1/Polyoma Enhancer-binding Protein 2alpha B/Core Binding Factor alpha 2.
L. Tang, B. Guo, A. Javed, J.-Y. Choi, S. Hiebert, J. B. Lian, A. J. van Wijnen, J. L. Stein, G. S. Stein, and G. W. Zhou (1999)
J. Biol. Chem. 274, 33580-33586
   Abstract »    Full Text »    PDF »


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