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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1352 - 1354
DOI: 10.1126/science.281.5381.1352
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Reports

Independent and Epigenetic Regulation of the Interleukin-4 Alleles in CD4+ T Cells

Mark Bix, Richard M. Locksley *

How an individual effector T cell acquires a particular cytokine expression pattern from many possible patterns remains unclear. CD4+ T cells from F1 mice, which allowed assignment of the parental origin of interleukin-4 (IL-4) transcripts, were divided into clones that expressed IL-4 biallelically or monoallelically from either allele. The allelic pattern was transmitted as a stable epigenetic trait. Regulation of cytokine expression by a mechanism that treats each allele independently suggests a probabilistic process by which a diverse repertoire of combinatorially assorted cytokine gene expression patterns could be generated among the clonally related daughters of a single precursor cell.

Howard Hughes Medical Institute and Departments of Medicine and Microbiology/Immunology, University of California, San Francisco (UCSF), San Francisco, CA 94143-0654, USA.
*   To whom correspondence should be addressed at UCSF, Box 0654, C-443, 521 Parnassus Avenue, San Francisco, CA 94143-0654, USA. E-mail: locksley{at}medicine.ucsf.edu

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