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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1317 - 1322
DOI: 10.1126/science.281.5381.1317
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Review

A Matter of Life and Cell Death

Gerard Evan, Trevor Littlewood

In multicellular organisms, mutations in somatic cells affecting critical genes that regulate cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious option, although the relative inconsequence of individual cells in metazoans means that it is often a "safer" strategy to ablate the offending cell. Not surprisingly, corruption of the machinery that senses or implements DNA damage greatly predisposes to cancer. Nonetheless, even when oncogenic mutations do occur, there exist potent mechanisms that limit the expansion of affected cells by suppressing their proliferation or triggering their suicide. Growing understanding of these innate mechanisms is suggesting novel therapeutic strategies for cancer.

The authors are at the Imperial Cancer Research Fund Laboratories, 44, Lincoln's Inn Fields, London WC2A 3PX, UK.

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DNA Fragmentation Decreased in Schizophrenia but Not Bipolar Disorder.
F. M. Benes, J. Walsh, S. Bhattacharyya, A. Sheth, and S. Berretta (2003)
Arch Gen Psychiatry 60, 359-364
   Abstract »    Full Text »    PDF »
Induction of Apoptosis by Paramyxovirus Simian Virus 5 Lacking a Small Hydrophobic Gene.
Y. Lin, A. C. Bright, T. A. Rothermel, and B. He (2003)
J. Virol. 77, 3371-3383
   Abstract »    Full Text »    PDF »
Selective Removal of the Selenocysteine tRNA[Ser]Sec Gene (Trsp) in Mouse Mammary Epithelium.
E. Kumaraswamy, B. A. Carlson, F. Morgan, K. Miyoshi, G. W. Robinson, D. Su, S. Wang, E. Southon, L. Tessarollo, B. J. Lee, et al. (2003)
Mol. Cell. Biol. 23, 1477-1488
   Abstract »    Full Text »    PDF »
Differential Roles of RelA (p65) and c-Rel Subunits of Nuclear Factor {kappa}B in Tumor Necrosis Factor-related Apoptosis-inducing Ligand Signaling.
X. Chen, K. Kandasamy, and R. K. Srivastava (2003)
Cancer Res. 63, 1059-1066
   Abstract »    Full Text »    PDF »
Identification and Validation of Genes Involved in the Pathogenesis of Colorectal Cancer Using cDNA Microarrays and RNA Interference.
N. S. Williams, R. B. Gaynor, S. Scoggin, U. Verma, T. Gokaslan, C. Simmang, J. Fleming, D. Tavana, E. Frenkel, and C. Becerra (2003)
Clin. Cancer Res. 9, 931-946
   Abstract »    Full Text »    PDF »
The human herpes virus 8-encoded viral FLICE inhibitory protein protects against growth factor withdrawal-induced apoptosis via NF-kappa B activation.
Q. Sun, H. Matta, and P. M. Chaudhary (2003)
Blood 101, 1956-1961
   Abstract »    Full Text »    PDF »
Translation Factor eIF4E Rescues Cells from Myc-dependent Apoptosis by Inhibiting Cytochrome c Release.
S. Li, T. Takasu, D. M. Perlman, M. S. Peterson, D. Burrichter, S. Avdulov, P. B. Bitterman, and V. A. Polunovsky (2003)
J. Biol. Chem. 278, 3015-3022
   Abstract »    Full Text »    PDF »
Heterogeneous Nuclear Ribonucleoprotein C Modulates Translation of c-myc mRNA in a Cell Cycle Phase-Dependent Manner.
J. H. Kim, K. Y. Paek, K. Choi, T.-D. Kim, B. Hahm, K.-T. Kim, and S. K. Jang (2003)
Mol. Cell. Biol. 23, 708-720
   Abstract »    Full Text »    PDF »
Pediatric Acute Lymphoblastic Leukemia.
W. L. Carroll, D. Bhojwani, D.-J. Min, E. Raetz, M. Relling, S. Davies, J. R. Downing, C. L. Willman, and J. C. Reed (2003)
Hematology 2003, 102-131
   Abstract »    Full Text »    PDF »
Advances in Biology and Therapy of Multiple Myeloma.
S. Barille-Nion, B. Barlogie, R. Bataille, P. L. Bergsagel, J. Epstein, R. G. Fenton, J. Jacobson, W. M. Kuehl, J. Shaughnessy, and G. Tricot (2003)
Hematology 2003, 248-278
   Abstract »    Full Text »    PDF »
Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli.
D. Arnoult, P. Parone, J.-C. Martinou, B. Antonsson, J. Estaquier, and J. C. Ameisen (2002)
J. Cell Biol. 159, 923-929
   Abstract »    Full Text »    PDF »
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in {beta}-Cell Adaptation and Failure in the Etiology of Diabetes.
M. Prentki, E. Joly, W. El-Assaad, and R. Roduit (2002)
Diabetes 51, S405-413
   Abstract »    Full Text »    PDF »
Involvement of survival motor neuron (SMN) protein in cell death.
S. Vyas, C. Bechade, B. Riveau, J. Downward, and A. Triller (2002)
Hum. Mol. Genet. 11, 2751-2764
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c-Myc Functionally Cooperates with Bax To Induce Apoptosis.
P. Juin, A. Hunt, T. Littlewood, B. Griffiths, L. B. Swigart, S. Korsmeyer, and G. Evan (2002)
Mol. Cell. Biol. 22, 6158-6169
   Abstract »    Full Text »    PDF »
Progression of Atheroma: A Struggle Between Death and Procreation.
Y.-J. Geng and P. Libby (2002)
Arterioscler Thromb Vasc Biol 22, 1370-1380
   Abstract »    Full Text »    PDF »
Controlled Elimination of Clathrin Heavy-Chain Expression in DT40 Lymphocytes.
F. R. Wettey, S. F. C. Hawkins, A. Stewart, J. P. Luzio, J. C. Howard, and A. P. Jackson (2002)
Science 297, 1521-1525
   Abstract »    Full Text »    PDF »


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