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Science 28 August 1998:
Vol. 281. no. 5381, pp. 1312 - 1316
DOI: 10.1126/science.281.5381.1312
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Review

Caspases: Enemies Within

Nancy A. Thornberry, Yuri Lazebnik

REVIEW

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

N. A. Thornberry is in the Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA. Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak..
D. Xiao, V. Vogel, and S. V. Singh (2006)
Mol. Cancer Ther. 5, 2931-2945
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Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-depende