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This article has been retracted

Science 14 August 1998:
Vol. 281. no. 5379, pp. 1009 - 1012
DOI: 10.1126/science.281.5379.1009
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Reports

BRCA1 Required for Transcription-Coupled Repair of Oxidative DNA Damage

Lori C. Gowen, Anna V. Avrutskaya, Anne M. Latour, Beverly H. Koller, Steven A. Leadon *

The breast and ovarian cancer susceptibility gene BRCA1 encodes a zinc finger protein of unknown function. Association of the BRCA1 protein with the DNA repair protein Rad51 and changes in the phosphorylation and cellular localization of the protein after exposure to DNA-damaging agents are consistent with a role for BRCA1 in DNA repair. Here, it is shown that mouse embryonic stem cells deficient in BRCA1 are defective in the ability to carry out transcription-coupled repair of oxidative DNA damage, and are hypersensitive to ionizing radiation and hydrogen peroxide. These results suggest that BRCA1 participates, directly or indirectly, in transcription-coupled repair of oxidative DNA damage.

L. C. Gowen, Curriculum in Genetics and Molecular Biology and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. A. V. Avrutskaya and S. A. Leadon, Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. A. M. Latour and B. H. Koller, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
*   To whom correspondence should be addressed. E-mail: saleadon{at}radonc.unc.edu

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Cold Spring Harb Symp Quant Biol 65, 561-566
   Abstract »    PDF »
Induced Micronucleus Frequencies in Peripheral Lymphocytes as a Screening Test for Carriers of a BRCA1 Mutation in Breast Cancer Families.
A. Rothfuss, P. Schütz, S. Bochum, T. Volm, E. Eberhardt, R. Kreienberg, W. Vogel, and G. Speit (2000)
Cancer Res. 60, 390-394
   Abstract »    Full Text »
Breast Carcinomas Arising in Carriers of Mutations in BRCA1 or BRCA2: Are They Prognostically Different?.
K.-A. Phillips, I. L. Andrulis, and P. J. Goodwin (1999)
J. Clin. Oncol. 17, 3653-3663
   Abstract »    Full Text »    PDF »
Zinc Finger of Replication Protein A, a Non-DNA Binding Element, Regulates Its DNA Binding Activity through Redox.
J.-S. Park, M. Wang, S.-J. Park, and S.-H. Lee (1999)
J. Biol. Chem. 274, 29075-29080
   Abstract »    Full Text »    PDF »
The Key and the Lamppost.
S. Hellman (1999)
J. Clin. Oncol. 17, 3007-3008
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Functional Interaction of BRCA1-Associated BARD1 with Polyadenylation Factor CstF-50.
F. E. Kleiman and J. L. Manley (1999)
Science 285, 1576-1579
   Abstract »    Full Text »
Potential roles for p53 in nucleotide excision repair.
B. C. McKay, M. Ljungman, and A. J. Rainbow1 (1999)
Carcinogenesis 20, 1389-1396
   Abstract »    Full Text »    PDF »
BRCA2 Is Required for Ionizing Radiation-induced Assembly of Rad51 Complex in Vivo.
S.-S. F. Yuan, S.-Y. Lee, G. Chen, M. Song, G. E. Tomlinson, and E. Y-H. P. Lee (1999)
Cancer Res. 59, 3547-3551
   Abstract »    Full Text »    PDF »
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response.
Q. Zhong, C. Chen, S. Li, Y. Chen, C. Wang, J. Xiao, P. Chen, Z. D. Sharp, and W. Lee (1999)
Science 285, 747-750
   Abstract »    Full Text »
BRCA1 Is Phosphorylated at Serine 1497 In Vivo at a Cyclin-Dependent Kinase 2 Phosphorylation Site.
H. Ruffner, W. Jiang, A. G. Craig, T. Hunter, and I. M. Verma (1999)
Mol. Cell. Biol. 19, 4843-4854
   Abstract »    Full Text »    PDF »
BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair.
D. W. Abbott, M. E. Thompson, C. Robinson-Benion, G. Tomlinson, R. A. Jensen, and J. T. Holt (1999)
J. Biol. Chem. 274, 18808-18812
   Abstract »    Full Text »    PDF »
BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells.
S. Fan, J. Wang, R. Yuan, Y. Ma, Q. Meng, M. R. Erdos, R. G. Pestell, F. Yuan, K. J. Auborn, I. D. Goldberg, et al. (1999)
Science 284, 1354-1356
   Abstract »    Full Text »
BRCA1 interacts with components of the histone deacetylase complex.
R. I. Yarden and L. C. Brody (1999)
PNAS 96, 4983-4988
   Abstract »    Full Text »    PDF »
Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage.
S. Li, P.-L. Chen, T. Subramanian, G. Chinnadurai, G. Tomlinson, C. K. Osborne, Z. D. Sharp, and W.-H. Lee (1999)
J. Biol. Chem. 274, 11334-11338
   Abstract »    Full Text »    PDF »
A Novel Signature Mutation for Oxidative Damage Resembles a Mutational Pattern Found Commonly in Human Cancers.
M. S. Turker, B. M. Gage, J. A. Rose, D. Elroy, O. N. Ponomareva, P. J. Stambrook, and J. A. Tischfield (1999)
Cancer Res. 59, 1837-1839
   Abstract »    Full Text »    PDF »


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