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Science 31 July 1998:
Vol. 281. no. 5377, pp. 706 - 709
DOI: 10.1126/science.281.5377.706
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Reports

Pioneer Axon Guidance by UNC-129, a C. elegans TGF-beta

Antonio Colavita, Srikant Krishna, Hong Zheng, Richard W. Padgett, Joseph G. Culotti *

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans. unc-129 encodes a member of the transforming growth factor-beta (TGF-beta ) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans.

A. Colavita, H. Zheng, J. G. Culotti, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada, and Department of Molecular and Medical Genetics, University of Toronto, Ontario M5S 1A8, Canada. S. Krishna and R. W. Padgett, Waksman Institute, Department of Molecular Biology and Biochemistry, and the Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ 08854-8020, USA.
*   To whom correspondence should be addressed. E-mail: culotti{at}mshri.on.ca

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