Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 17 July 1998:
Vol. 281. no. 5375, pp. 416 - 419
DOI: 10.1126/science.281.5375.416
Prev | Table of Contents | Next

Reports

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

James L. Clements, Baoli Yang, Susan E. Ross-Barta, Steve L. Eliason, Ronald F. Hrstka, Roger A. Williamson, Gary A. Koretzky *

The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events.

J. L. Clements, S. E. Ross-Barta, S. L. Eliason, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA. B. Yang, R. F. Hrstka, R. A. Williamson, Department of Obstetrics and Gynecology, University of Iowa College of Medicine, Iowa City, IA 52242, USA. G. A. Koretzky, Departments of Internal Medicine and Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
*   To whom correspondence should be addressed. E-mail: gary-koretzky{at}uiowa.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Adapter Protein SLP-76 Mediates "Outside-In" Integrin Signaling and Function in T Cells.
R. G. Baker, C. J. Hsu, D. Lee, M. S. Jordan, J. S. Maltzman, D. A. Hammer, T. Baumgart, and G. A. Koretzky (2009)
Mol. Cell. Biol. 29, 5578-5589
   Abstract »    Full Text »    PDF »
SLP-76 Couples Syk to the Osteoclast Cytoskeleton.
J. L. Reeve, W. Zou, Y. Liu, J. S. Maltzman, F. P. Ross, and S. L. Teitelbaum (2009)
J. Immunol. 183, 1804-1812
   Abstract »    Full Text »    PDF »
Syk Tyrosine 317 Negatively Regulates Osteoclast Function via the Ubiquitin-Protein Isopeptide Ligase Activity of Cbl.
W. Zou, J. L. Reeve, H. Zhao, F. P. Ross, and S. L. Teitelbaum (2009)
J. Biol. Chem. 284, 18833-18839
   Abstract »    Full Text »    PDF »
The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-{alpha} motif domain in thymic selection and T-cell activation.
S. Shen, J. Lau, M. Zhu, J. Zou, D. Fuller, Q.-j. Li, and W. Zhang (2009)
Blood 114, 74-84
   Abstract »    Full Text »    PDF »
Cutting Edge: Rescue of Pre-TCR but Not Mature TCR Signaling in Mice Expressing Membrane-Targeted SLP-76.
N. A. Bezman, R. G. Baker, L. E. Lenox, M. S. Jordan, and G. A. Koretzky (2009)
J. Immunol. 182, 5183-5187
   Abstract »    Full Text »    PDF »
The Essential Role of LAT in Thymocyte Development during Transition from the Double-Positive to Single-Positive Stage.
S. Shen, M. Zhu, J. Lau, M. Chuck, and W. Zhang (2009)
J. Immunol. 182, 5596-5604
   Abstract »    Full Text »    PDF »
Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation.
Y. J. Chiang, M. S. Jordan, R. Horai, P. L. Schwartzberg, G. A. Koretzky, and R. J. Hodes (2009)
J. Biol. Chem. 284, 4429-4438
   Abstract »    Full Text »    PDF »
Negative Regulation of TCR Signaling by Linker for Activation of X Cells via Phosphotyrosine-Dependent and -Independent Mechanisms.
M. J. Shapiro, C. T. Nguyen, H. Aghajanian, W. Zhang, and V. S. Shapiro (2008)
J. Immunol. 181, 7055-7061
   Abstract »    Full Text »    PDF »
Selective Regulation of TCR Signaling Pathways by the CD45 Protein Tyrosine Phosphatase during Thymocyte Development.
R. Falahati and D. Leitenberg (2008)
J. Immunol. 181, 6082-6091
   Abstract »    Full Text »    PDF »
Distinct Regulation of Integrin-Dependent T Cell Conjugate Formation and NF-{kappa}B Activation by the Adapter Protein ADAP.
B. J. Burbach, R. Srivastava, R. B. Medeiros, W. E. O'Gorman, E. J. Peterson, and Y. Shimizu (2008)
J. Immunol. 181, 4840-4851
   Abstract »    Full Text »    PDF »
Selective impairment of Fc{varepsilon}RI-mediated allergic reaction in Gads-deficient mice.
S. Yamasaki, M. Takase-Utsugi, E. Ishikawa, M. Sakuma, K. Nishida, T. Saito, and O. Kanagawa (2008)
Int. Immunol. 20, 1289-1297
   Abstract »    Full Text »    PDF »
c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells.
N. C. Brembilla, J. Weber, D. Rimoldi, S. Pradervand, F. Schutz, G. Pantaleo, C. Ruegg, M. Quadroni, K. Harshman, and M.-A. Doucey (2008)
Blood 112, 652-660
   Abstract »    Full Text »    PDF »
Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-{gamma} production.
S. Hidano, H. Sasanuma, K. Ohshima, K.-i. Seino, L. Kumar, K. Hayashi, M. Hikida, T. Kurosaki, M. Taniguchi, R. S. Geha, et al. (2008)
Int. Immunol. 20, 345-352
   Abstract »    Full Text »    PDF »
Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.
K. Ramsey, N. Luckashenak, G. A. Koretzky, and J. L. Clements (2008)
J. Leukoc. Biol. 83, 419-429
   Abstract »    Full Text »    PDF »
Defective T Cell Development and Function in the Absence of Abelson Kinases.
J. J. Gu, N. Zhang, Y.-W. He, A. J. Koleske, and A. M. Pendergast (2007)
J. Immunol. 179, 7334-7343
   Abstract »    Full Text »    PDF »
Subtle Defects in Pre-TCR Signaling in the Absence of the Tec Kinase Itk.
J. A. Lucas, M. Felices, J. W. Evans, and L. J. Berg (2007)
J. Immunol. 179, 7561-7567
   Abstract »    Full Text »    PDF »
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
A. M. Michie, A. C. Chan, M. Ciofani, M. Carleton, J. M. Lefebvre, Y. He, D. M. Allman, D. L. Wiest, J. C. Zuniga-Pflucker, and D. J. Izon (2007)
Int. Immunol. 19, 1421-1430
   Abstract »    Full Text »    PDF »
Akt1 and Akt2 are required for {alpha}beta thymocyte survival and differentiation.
M. M. Juntilla, J. A. Wofford, M. J. Birnbaum, J. C. Rathmell, and G. A. Koretzky (2007)
PNAS 104, 12105-12110
   Abstract »    Full Text »    PDF »
Gads-/- Mice Reveal Functionally Distinct Subsets of TCRbeta+ CD4-CD8- Double-Negative Thymocytes.
L. Zeng, S. L. Dalheimer, and T. M. Yankee (2007)
J. Immunol. 179, 1013-1021
   Abstract »    Full Text »    PDF »
Distinct roles for Syk and ZAP-70 during early thymocyte development.
E. H. Palacios and A. Weiss (2007)
J. Exp. Med. 204, 1703-1715
   Abstract »    Full Text »    PDF »
The C-type Lectin Receptors CLEC-2 and Dectin-1, but Not DC-SIGN, Signal via a Novel YXXL-dependent Signaling Cascade.
G. L. J. Fuller, J. A. E. Williams, M. G. Tomlinson, J. A. Eble, S. L. Hanna, S. Pohlmann, K. Suzuki-Inoue, Y. Ozaki, S. P. Watson, and A. C. Pearce (2007)
J. Biol. Chem. 282, 12397-12409
   Abstract »    Full Text »    PDF »
Loss of SLP-76 Expression within Myeloid Cells Confers Resistance to Neutrophil-Mediated Tissue Damage while Maintaining Effective Bacterial Killing.
R. A. Clemens, L. E. Lenox, T. Kambayashi, N. Bezman, J. S. Maltzman, K. E. Nichols, and G. A. Koretzky (2007)
J. Immunol. 178, 4606-4614
   Abstract »    Full Text »    PDF »
ShcA Mediates the Dominant Pathway to Extracellular Signal-Regulated Kinase Activation during Early Thymic Development.
P. Trampont, L. Zhang, and K. S. Ravichandran (2006)
Mol. Cell. Biol. 26, 9035-9044
   Abstract »    Full Text »    PDF »
Novel Platelet and Vascular Roles for Immunoreceptor Signaling.
F. F. Samaha and M. L. Kahn (2006)
Arterioscler Thromb Vasc Biol 26, 2588-2593
   Abstract »    Full Text »    PDF »
The Src Homology 2 Domain-Containing Leukocyte Protein of 76-kDa Adaptor Links Integrin Ligation with p44/42 MAPK Phosphorylation and Podosome Distribution in Murine Dendritic Cells.
N. A. Luckashenak, R. L. Ryszkiewicz, K. D. Ramsey, and J. L. Clements (2006)
J. Immunol. 177, 5177-5185
   Abstract »    Full Text »    PDF »
Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells..
F. Abtahian, N. Bezman, R. Clemens, E. Sebzda, L. Cheng, S. J. Shattil, M. L. Kahn, and G. A. Koretzky (2006)
Mol. Cell. Biol. 26, 6936-6949
   Abstract »    Full Text »    PDF »
Adhesion- and Degranulation-Promoting Adapter Protein Is Required for Efficient Thymocyte Development and Selection..
J. N. Wu, S. Gheith, N. A. Bezman, Q.-H. Liu, L. V. Fostel, A. M. Swanson, B. D. Freedman, G. A. Koretzky, and E. J. Peterson (2006)
J. Immunol. 176, 6681-6689
   Abstract »    Full Text »    PDF »
A Role for MAPK in Feedback Inhibition of Tcrb Recombination..
A. M. Jackson and M. S. Krangel (2006)
J. Immunol. 176, 6824-6830
   Abstract »    Full Text »    PDF »
Dual function for the adaptor MIST in IFN-{gamma} production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
H. Sasanuma, A. Tatsuno, S. Hidano, K. Ohshima, Y. Matsuzaki, K. Hayashi, C. A. Lowell, D. Kitamura, and R. Goitsuka (2006)
Blood 107, 3647-3655
   Abstract »    Full Text »    PDF »
Disruption of SLP-76 Interaction with Gads Inhibits Dynamic Clustering of SLP-76 and Fc{varepsilon}RI Signaling in Mast Cells..
M. A. Silverman, J. Shoag, J. Wu, and G. A. Koretzky (2006)
Mol. Cell. Biol. 26, 1826-1838
   Abstract »    Full Text »    PDF »
Functional Hierarchy of the N-Terminal Tyrosines of SLP-76.
M. S. Jordan, J. Sadler, J. E. Austin, L. D. Finkelstein, A. L. Singer, P. L. Schwartzberg, and G. A. Koretzky (2006)
J. Immunol. 176, 2430-2438
   Abstract »    Full Text »    PDF »
A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
L. Kumar, S. Feske, A. Rao, and R. S. Geha (2005)
PNAS 102, 19063-19068
   Abstract »    Full Text »    PDF »
Short-Interfering RNA-Mediated Lck Knockdown Results in Augmented Downstream T Cell Responses.
T. Methi, J. Ngai, M. Mahic, M. Amarzguioui, T. Vang, and K. Tasken (2005)
J. Immunol. 175, 7398-7406
   Abstract »    Full Text »    PDF »
Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection.
J. S. Maltzman, L. Kovoor, J. L. Clements, and G. A. Koretzky (2005)
J. Exp. Med. 202, 893-900
   Abstract »    Full Text »    PDF »
Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells.
A. A. Maghazachi (2005)
Pharmacol. Rev. 57, 339-357
   Abstract »    Full Text »    PDF »
Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks {beta}-Selection.
J. M. Lefebvre, M. C. Haks, M. O. Carleton, M. Rhodes, G. Sinnathamby, M. C. Simon, L. C. Eisenlohr, L. A. Garrett-Sinha, and D. L. Wiest (2005)
J. Immunol. 174, 6184-6194
   Abstract »    Full Text »    PDF »
PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function.
R. A. Clemens, S. A. Newbrough, E. Y. Chung, S. Gheith, A. L. Singer, G. A. Koretzky, and E. J. Peterson (2004)
Mol. Cell. Biol. 24, 10923-10932
   Abstract »    Full Text »    PDF »
The Gads (GrpL) Adaptor Protein Regulates T Cell Homeostasis.
T. M. Yankee, T. J. Yun, K. E. Draves, K. Ganesh, M. J. Bevan, K. Murali-Krishna, and E. A. Clark (2004)
J. Immunol. 173, 1711-1720
   Abstract »    Full Text »    PDF »
Inactivation of c-Cbl Reverses Neonatal Lethality and T Cell Developmental Arrest of SLP-76-deficient Mice.
Y. J. Chiang, C. L. Sommers, M. S. Jordan, H. Gu, L. E. Samelson, G. A. Koretzky, and R. J. Hodes (2004)
J. Exp. Med. 200, 25-34
   Abstract »    Full Text »    PDF »
Immune Functions in Mice Lacking Clnk, an SLP-76-Related Adaptor Expressed in a Subset of Immune Cells.
O. Utting, B. J. Sedgmen, T. H. Watts, X. Shi, R. Rottapel, A. Iulianella, D. Lohnes, and A. Veillette (2004)
Mol. Cell. Biol. 24, 6067-6075
   Abstract »    Full Text »    PDF »
Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein.
S.-H. Lee, Y.-H. Chung, N.-H. Cho, Y. Gwack, P. Feng, and J. U. Jung (2004)
Mol. Cell. Biol. 24, 5369-5382
   Abstract »    Full Text »    PDF »
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function.
A. L. Singer, S. C. Bunnell, A. E. Obstfeld, M. S. Jordan, J. N. Wu, P. S. Myung, L. E. Samelson, and G. A. Koretzky (2004)
J. Biol. Chem. 279, 15481-15490
   Abstract »    Full Text »    PDF »
The Importance of Three Membrane-distal Tyrosines in the Adaptor Protein NTAL/LAB.
S. Koonpaew, E. Janssen, M. Zhu, and W. Zhang (2004)
J. Biol. Chem. 279, 11229-11235
   Abstract »    Full Text »    PDF »
Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains.
M. Iseki, C. Kubo, S.-M. Kwon, A. Yamaguchi, Y. Kataoka, N. Yoshida, K. Takatsu, and S. Takaki (2004)
Mol. Cell. Biol. 24, 2243-2250
   Abstract »    Full Text »    PDF »
Macrophage activation and Fc{gamma} receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors.
K. E. Nichols, K. Haines, P. S. Myung, S. Newbrough, E. Myers, H. Jumaa, D. J. Shedlock, H. Shen, and G. A. Koretzky (2004)
J. Leukoc. Biol. 75, 541-552
   Abstract »    Full Text »    PDF »
Early Growth Response Gene 3 Regulates Thymocyte Proliferation during the Transition from CD4-CD8- to CD4+CD8+1.
H. Xi and G. J. Kersh (2004)
J. Immunol. 172, 964-971
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Src Homology 2 Domain-Containing Leukocyte Phosphoprotein of 76 kDa: Dissection of Key Promoter Elements.
X.-P. Zhong, J. S. Maltzman, E. A. Hainey, and G. A. Koretzky (2003)
J. Immunol. 171, 6621-6629
   Abstract »    Full Text »    PDF »
T Cell Rewiring in Differentiation and Disease.
S. Krishnan, D. L. Farber, and G. C. Tsokos (2003)
J. Immunol. 171, 3325-3331
   Full Text »    PDF »
Linker for Activation of T Cells, {zeta}-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization.
M. R. Kuhne, J. Lin, D. Yablonski, M. N. Mollenauer, L. I. R. Ehrlich, J. Huppa, M. M. Davis, and A. Weiss (2003)
J. Immunol. 171, 860-866
   Abstract »    Full Text »    PDF »
SH2 and PTB Domains in Tyrosine Kinase Signaling.
J. Schlessinger and M. A. Lemmon (2003)
Sci. STKE 2003, re12
   Abstract »    Full Text »    PDF »
Distinct Role of ZAP-70 and Src Homology 2 Domain-Containing Leukocyte Protein of 76 kDa in the Prolonged Activation of Extracellular Signal-Regulated Protein Kinase by the Stromal Cell-Derived Factor-1{alpha}/CXCL12 Chemokine.
K. N. Kremer, T. D. Humphreys, A. Kumar, N.-X. Qian, and K. E. Hedin (2003)
J. Immunol. 171, 360-367
   Abstract »    Full Text »    PDF »
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity.
M.-A. Kang, S.-Y. Yun, and J. Won (2003)
Blood 101, 3534-3542
   Abstract »    Full Text »    PDF »
Structural Requirements of SLP-76 in Signaling via the High-Affinity Immunoglobulin E Receptor (Fc{varepsilon}RI) in Mast Cells.
A. Kettner, V. Pivniouk, L. Kumar, H. Falet, J.-S. Lee, R. Mulligan, and R. S. Geha (2003)
Mol. Cell. Biol. 23, 2395-2406
   Abstract »    Full Text »    PDF »
Characterization of promoter elements directing Mona/Gads molecular adapter expression in T and myelomonocytic cells: involvement of the AML-1 transcription factor.
B. Guyot and G. Mouchiroud (2003)
J. Leukoc. Biol. 73, 263-272
   Abstract »    Full Text »    PDF »
Immunodeficiency Disorders.
M. D. Cooper, L. L. Lanier, M. E. Conley, and J. M. Puck (2003)
Hematology 2003, 314-330
   Abstract »    Full Text »    PDF »
SKAP55 Recruits to Lipid Rafts and Positively Mediates the MAPK Pathway upon T Cell Receptor Activation.
L. Wu, Z. Yu, and S.-H. Shen (2002)
J. Biol. Chem. 277, 40420-40427
   Abstract »    Full Text »    PDF »
Role of the adapter protein SLP-76 in GPVI-dependent platelet procoagulant responses to collagen.
L. Leo, J. Di Paola, B. A. Judd, G. A. Koretzky, and S. R. Lentz (2002)
Blood 100, 2839-2844
   Abstract »    Full Text »    PDF »
Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens.
R. J. McKallip, Y. Do, M. T. Fisher, J. L. Robertson, P. S. Nagarkatti, and M. Nagarkatti (2002)
Int. Immunol. 14, 1015-1026
   Abstract »    Full Text »    PDF »
Dok-related protein negatively regulates T cell development via its RasGTPase-activating protein and Nck docking sites.
R. Gugasyan, C. Quilici, S. T.T. I, D. Grail, A. M. Verhagen, A. Roberts, T. Kitamura, A. R. Dunn, and P. Lock (2002)
J. Cell Biol. 158, 115-125
   Abstract »    Full Text »    PDF »
Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction.
R. Shen, Y.-B. Ouyang, C.-K. Qu, A. Alonso, L. Sperzel, T. Mustelin, M. H. Kaplan, and G.-S. Feng (2002)
Mol. Cell. Biol. 22, 3230-3236
   Abstract »    Full Text »    PDF »
Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling.
B. A. Judd, P. S. Myung, A. Obergfell, E. E. Myers, A. M. Cheng, S. P. Watson, W. S. Pear, D. Allman, S. J. Shattil, and G. A. Koretzky (2002)
J. Exp. Med. 195, 705-717
   Abstract »    Full Text »    PDF »
Differential SLP-76 Expression and TCR-Mediated Signaling in Effector and Memory CD4 T Cells.
S. F. Hussain, C. F. Anderson, and D. L. Farber (2002)
J. Immunol. 168, 1557-1565
   Abstract »    Full Text »    PDF »
Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap.
E. K. Griffiths, C. Krawczyk, Y.-Y. Kong, M. Raab, S. J. Hyduk, D. Bouchard, V. S. Chan, I. Kozieradzki, A. J. Oliveira-dos-Santos, A. Wakeham, et al. (2001)
Science 293, 2260-2263
   Abstract »    Full Text »    PDF »
Coupling of the TCR to Integrin Activation by SLAP-130/Fyb.
E. J. Peterson, M. L. Woods, S. A. Dmowski, G. Derimanov, M. S. Jordan, J. N. Wu, P. S. Myung, Q.-H. Liu, J. T. Pribila, B. D. Freedman, et al. (2001)
Science 293, 2263-2265
   Abstract »    Full Text »    PDF »
Synergistic Regulation of Immunoreceptor Signaling by SLP-76-Related Adaptor Clnk and Serine/Threonine Protein Kinase HPK-1.
J. Yu, C. Riou, D. Davidson, R. Minhas, J. D. Robson, M. Julius, R. Arnold, F. Kiefer, and A. Veillette (2001)
Mol. Cell. Biol. 21, 6102-6112
   Abstract »    Full Text »    PDF »
Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells.
D. Allman, F. G. Karnell, J. A. Punt, S. Bakkour, L. Xu, P. Myung, G. A. Koretzky, J. C. Pui, J. C. Aster, and W. S. Pear (2001)
J. Exp. Med. 194, 99-106
   Abstract »    Full Text »    PDF »
Identification of a Phospholipase C-{gamma}1 (PLC-{gamma}1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-{gamma}1 and NFAT.
D. Yablonski, T. Kadlecek, and A. Weiss (2001)
Mol. Cell. Biol. 21, 4208-4218
   Abstract »    Full Text »    PDF »
Signaling networks regulating {beta}1 integrin-mediated adhesion of T lymphocytes to extracellular matrix.
M. L. Woods and Y. Shimizu (2001)
J. Leukoc. Biol. 69, 874-880
   Abstract »    Full Text »    PDF »
Vav1 Regulates Phospholipase C{gamma} Activation and Calcium Responses in Mast Cells.
T. S. Manetz, C. Gonzalez-Espinosa, R. Arudchandran, S. Xirasagar, V. Tybulewicz, and J. Rivera (2001)
Mol. Cell. Biol. 21, 3763-3774
   Abstract »    Full Text »
Suppression of thymic development by the dominant-negative form of Gads.
K. Kikuchi, Y. Kawasaki, N. Ishii, Y. Sasaki, H. Asao, T. Takeshita, I. Miyoshi, N. Kasai, and K. Sugamura (2001)
Int. Immunol. 13, 777-783
   Abstract »    Full Text »    PDF »
Protein Tyrosine Phosphatase CD148-Mediated Inhibition of T-Cell Receptor Signal Transduction Is Associated with Reduced LAT and Phospholipase C{gamma}1 Phosphorylation.
J. E. Baker, R. Majeti, S. G. Tangye, and A. Weiss (2001)
Mol. Cell. Biol. 21, 2393-2403
   Abstract »    Full Text »
Molecular motors involved in T cell receptor clusterings.
C. Krawczyk and J. M. Penninger (2001)
J. Leukoc. Biol. 69, 317-330
   Abstract »    Full Text »
Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-{beta}-treated alloreactive T cells that do not induce graft-versus-host disease.
V. A. Boussiotis, Z.-M. Chen, J. C. Zeller, W. J. Murphy, A. Berezovskaya, S. Narula, M. G. Roncarolo, and B. R. Blazar (2001)
Blood 97, 565-571
   Abstract »    Full Text »    PDF »
Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.
A. M. Michie, J.-W. Soh, R. G. Hawley, I. B. Weinstein, and J. C. Zúñiga-Pflücker (2001)
PNAS
   Abstract »    Full Text »
Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRgamma -chain complex.
H. Falet, K. L. Barkalow, V. I. Pivniouk, M. J. Barnes, R. S. Geha, and J. H. Hartwig (2000)
Blood 96, 3786-3792
   Abstract »    Full Text »    PDF »
Regulation of {beta}1 Integrin-Mediated Adhesion by T Cell Receptor Signaling Involves ZAP-70 but Differs from Signaling Events That Regulate Transcriptional Activity.
J. A. Epler, R. Liu, H. Chung, N. C. Ottoson, and Y. Shimizu (2000)
J. Immunol. 165, 4941-4949
   Abstract »    Full Text »    PDF »
Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIbbeta 3 and collagen receptors.
B. A. Judd, P. S. Myung, L. Leng, A. Obergfell, W. S. Pear, S. J. Shattil, and G. A. Koretzky (2000)
PNAS 97, 12056-12061
   Abstract »    Full Text »    PDF »
Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling.
N. J. Boerth, J. J. Sadler, D. E. Bauer, J. L. Clements, S. M. Gheith, and G. A. Koretzky (2000)
J. Exp. Med. 192, 1047-1058
   Abstract »    Full Text »    PDF »
A Profound Deficiency in Thymic Progenitor Cells in Mice Lacking Jak3.
A. M. Baird, J. A. Lucas, and L. J. Berg (2000)
J. Immunol. 165, 3680-3688
   Abstract »    Full Text »    PDF »
Involvement of Lat, Gads, and Grb2 in Compartmentation of Slp-76 to the Plasma Membrane.
M. Ishiai, M. Kurosaki, K. Inabe, A. C. Chan, K. Sugamura, and T. Kurosaki (2000)
J. Exp. Med. 192, 847-856
   Abstract »    Full Text »    PDF »
Early Onset of CD8 Transgene Expression Inhibits the Transition from DN3 to DP Thymocytes.
A. Wack, M. Coles, T. Norton, A. Hostert, and D. Kioussis (2000)
J. Immunol. 165, 1236-1242
   Abstract »    Full Text »    PDF »
The Adaptor Protein Gads (Grb2-Related Adaptor Downstream of Shc) Is Implicated in Coupling Hemopoietic Progenitor Kinase-1 to the Activated TCR.
S. K. Liu, C. A. Smith, R. Arnold, F. Kiefer, and C. J. McGlade (2000)
J. Immunol. 165, 1417-1426
   Abstract »    Full Text »    PDF »
TCR/CD3-Induced Activation and Binding of Emt/Itk to Linker of Activated T Cell Complexes: Requirement for the Src Homology 2 Domain.
K. A. Ching, J. A. Grasis, P. Tailor, Y. Kawakami, T. Kawakami, and C. D. Tsoukas (2000)
J. Immunol. 165, 256-262
   Abstract »    Full Text »    PDF »
In vitro and in vivo macrophage function can occur independently of SLP-76.
P. S. Myung, J. L. Clements, D. W. White, Z. A. Malik, J. S. Cowdery, L.-A. H. Allen, J. T. Harty, D. J. Kusner, and G. A. Koretzky (2000)
Int. Immunol. 12, 887-897
   Abstract »    Full Text »    PDF »
RasGRP links T-cell receptor signaling to Ras.
J. O. Ebinu, S. L. Stang, C. Teixeira, D. A. Bottorff, J. Hooton, P. M. Blumberg, M. Barry, R. C. Bleakley, H. L. Ostergaard, and J. C. Stone (2000)
Blood 95, 3199-3203
   Abstract »    Full Text »    PDF »
A Novel B Lymphocyte-Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase.
A. J. Marshall, H. Niiro, C. G. Lerner, T. J. Yun, S. Thomas, C. M. Disteche, and E. A. Clark (2000)
J. Exp. Med. 191, 1319-1332
   Abstract »    Full Text »    PDF »
A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.
R. Goitsuka, H. Kanazashi, H. Sasanuma, Y.-i. Fujimura, Y. Hidaka, A. Tatsuno, C. Ra, K. Hayashi, and D. Kitamura (2000)
Int. Immunol. 12, 573-580
   Abstract »    Full Text »    PDF »
Vav Synergizes with Protein Kinase C{Theta} to Mediate IL-4 Gene Expression in Response to CD28 Costimulation in T Cells.
S. P. Hehner, M. Li-Weber, M. Giaisi, W. Droge, P. H. Krammer, and M. L. Schmitz (2000)
J. Immunol. 164, 3829-3836
   Abstract »    Full Text »    PDF »
B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice.
S. Xu, J. E.-L. Tan, E. P.-Y. Wong, A. Manickam, S. Ponniah, and K.-P. Lam (2000)
Int. Immunol. 12, 397-404
   Abstract »    Full Text »    PDF »
MEK Activity Regulates Negative Selection of Immature CD4+CD8+ Thymocytes.
U. Bommhardt, Y. Scheuring, C. Bickel, R. Zamoyska, and T. Hunig (2000)
J. Immunol. 164, 2326-2337
   Abstract »    Full Text »    PDF »
Lck Domains Differentially Contribute to Pre-T Cell Receptor (Tcr)-And TCR-{alpha}/{beta}-Regulated Developmental Transitions.
K. Lin, N. S. Longo, X. Wang, J. A. Hewitt, and K. M. Abraham (2000)
J. Exp. Med. 191, 703-716
   Abstract »    Full Text »    PDF »
Differential T-Cell Antigen Receptor Signaling Mediated by the Src Family Kinases Lck and Fyn.
M. F. Denny, B. Patai, and D. B. Straus (2000)
Mol. Cell. Biol. 20, 1426-1435
   Abstract »    Full Text »
Resting Lymphocyte Kinase (Rlk/Txk) Targets Lymphoid Adaptor SLP-76 in the Cooperative Activation of Interleukin-2 Transcription in T-cells.
H. Schneider, B. Guerette, C. Guntermann, and C. E. Rudd (2000)
J. Biol. Chem. 275, 3835-3840
   Abstract »    Full Text »    PDF »
Cutting Edge: A Novel Function for the SLAP-130/FYB Adapter Protein in {beta}1 Integrin Signaling and T Lymphocyte Migration.
A. J. Hunter, N. Ottoson, N. Boerth, G. A. Koretzky, and Y. Shimizu (2000)
J. Immunol. 164, 1143-1147
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)