Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 17 July 1998:
Vol. 281. no. 5375, pp. 363 - 365
DOI: 10.1126/science.281.5375.363

Tech.Sight

DNA SEQUENCING:
A Sequencing Method Based on Real-Time Pyrophosphate

Mostafa Ronaghi, Mathias Uhlén, and Pål Nyrén

Mailbox:www.sciencemag.org/dmail.cgi?53491

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Orphelia: predicting genes in metagenomic sequencing reads.
K. J. Hoff, T. Lingner, P. Meinicke, and M. Tech (2009)
Nucleic Acids Res. 37, W101-W105
   Abstract »    Full Text »    PDF »
Flow cytometry for enrichment and titration in massively parallel DNA sequencing.
J. Sandberg, P. L. Stahl, A. Ahmadian, M. K. Bjursell, and J. Lundeberg (2009)
Nucleic Acids Res. 37, e63
   Abstract »    Full Text »    PDF »
Whole-Genome-Based Phylogeny and Divergence of the Genus Brucella.
J. T. Foster, S. M. Beckstrom-Sternberg, T. Pearson, J. S. Beckstrom-Sternberg, P. S. G. Chain, F. F. Roberto, J. Hnath, T. Brettin, and P. Keim (2009)
J. Bacteriol. 191, 2864-2870
   Abstract »    Full Text »    PDF »
Next-Generation Sequencing: From Basic Research to Diagnostics.
K. V. Voelkerding, S. A. Dames, and J. D. Durtschi (2009)
Clin. Chem. 55, 641-658
   Abstract »    Full Text »    PDF »
Real-Time DNA Sequencing from Single Polymerase Molecules.
J. Eid, A. Fehr, J. Gray, K. Luong, J. Lyle, G. Otto, P. Peluso, D. Rank, P. Baybayan, B. Bettman, et al. (2009)
Science 323, 133-138
   Abstract »    Full Text »    PDF »
The perils of plenty: what are we going to do with all these genes?.
A. Rodrigo, F. Bertels, J. Heled, R. Noder, H. Shearman, and P. Tsai (2008)
Phil Trans R Soc B 363, 3893-3902
   Abstract »    Full Text »    PDF »
Pyrosequencing analysis of the Oral Microflora of healthy adults.
B.J.F. Keijser, E. Zaura, S.M. Huse, J.M.B.M. van der Vossen, F.H.J. Schuren, R.C. Montijn, J.M. ten Cate, and W. Crielaard (2008)
Journal of Dental Research 87, 1016-1020
   Abstract »    Full Text »    PDF »
Nested Patch PCR enables highly multiplexed mutation discovery in candidate genes.
K. E. Varley and R. D. Mitra (2008)
Genome Res. 18, 1844-1850
   Abstract »    Full Text »    PDF »
Cerebellar {alpha}-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.
M. Westerlund, A. C. Belin, A. Anvret, A. Hakansson, H. Nissbrandt, C. Lind, O. Sydow, L. Olson, and D. Galter (2008)
FASEB J 22, 3509-3514
   Abstract »    Full Text »    PDF »
Four-color DNA sequencing with 3'-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides.
J. Guo, N. Xu, Z. Li, S. Zhang, J. Wu, D. H. Kim, M. Sano Marma, Q. Meng, H. Cao, X. Li, et al. (2008)
PNAS 105, 9145-9150
   Abstract »    Full Text »    PDF »
Typing of SHV Extended-Spectrum {beta}-Lactamases by Pyrosequencing in Klebsiella pneumoniae Strains with Chromosomal SHV {beta}-Lactamase.
M. Haanpera, S. D. Forssten, P. Huovinen, and J. Jalava (2008)
Antimicrob. Agents Chemother. 52, 2632-2635
   Abstract »    Full Text »    PDF »
The new paradigm of flow cell sequencing.
R. A. Holt and S. J.M. Jones (2008)
Genome Res. 18, 839-846
   Abstract »    Full Text »    PDF »
Frequency and Effect of the Bovine Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) K232A Polymorphism in Swedish Dairy Cattle.
J. Naslund, W. F. Fikse, G. R. Pielberg, and A. Lunden (2008)
J Dairy Sci 91, 2127-2134
   Abstract »    Full Text »    PDF »
Rapid comparative genomic analysis for clinical microbiology: The Francisella tularensis paradigm.
B. La Scola, K. Elkarkouri, W. Li, T. Wahab, G. Fournous, J.-M. Rolain, S. Biswas, M. Drancourt, C. Robert, S. Audic, et al. (2008)
Genome Res. 18, 742-750
   Abstract »    Full Text »    PDF »
Quantitative Promoter Hypermethylation Analysis of Cancer-Related Genes in Salivary Gland Carcinomas: Comparison with Methylation-Specific PCR Technique and Clinical Significance.
E.-S. Lee, J.-P. Issa, D. B. Roberts, M. D. Williams, R. S. Weber, M. S. Kies, and A. K. El-Naggar (2008)
Clin. Cancer Res. 14, 2664-2672
   Abstract »    Full Text »    PDF »
The HIV-1 protease substitution K55R: a protease-inhibitor-associated substitution involved in restoring viral replication.
E. S. Margerison, M. Maguire, D. Pillay, P. Cane, and R. C. Elston (2008)
J. Antimicrob. Chemother. 61, 786-791
   Abstract »    Full Text »    PDF »
Combined Real-Time PCR and Pyrosequencing Strategy for Objective, Sensitive, Specific, and High-Throughput Identification of Reduced Susceptibility to Penicillins in Neisseria meningitidis.
S. Thulin, P. Olcen, H. Fredlund, and M. Unemo (2008)
Antimicrob. Agents Chemother. 52, 753-756
   Abstract »    Full Text »    PDF »
Short read fragment assembly of bacterial genomes.
M. J. Chaisson and P. A. Pevzner (2008)
Genome Res. 18, 324-330
   Abstract »    Full Text »    PDF »
Multiple Hybridization-extension Sequencing (MHES) on Microarray.
Z. Pan, Y. Li, P. Xiao, and Z. Lu (2007)
J. Biochem. 142, 605-611
   Abstract »    Full Text »    PDF »
3'-O-modified nucleotides as reversible terminators for pyrosequencing.
J. Wu, S. Zhang, Q. Meng, H. Cao, Z. Li, X. Li, S. Shi, D. H. Kim, L. Bi, N. J. Turro, et al. (2007)
PNAS 104, 16462-16467
   Abstract »    Full Text »    PDF »
Termination of DNA synthesis by N6-alkylated, not 3'-O-alkylated, photocleavable 2'-deoxyadenosine triphosphates.
W. Wu, B. P. Stupi, V. A. Litosh, D. Mansouri, D. Farley, S. Morris, S. Metzker, and M. L. Metzker (2007)
Nucleic Acids Res. 35, 6339-6349
   Abstract »    Full Text »    PDF »
Plasma Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-A Gene Polymorphism are Associated with Hydrocele Development in Lymphatic Filariasis.
A. Y. Debrah, S. Mand, M. R. Toliat, Y. Marfo-Debrekyei, L. Batsa, P. Nurnberg, B. Lawson, O. Adjei, A. Hoerauf, and K. Pfarr (2007)
Am J Trop Med Hyg 77, 601-608
   Abstract »    Full Text »    PDF »
Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study.
F D Dick, G De Palma, A Ahmadi, A Osborne, N W Scott, G J Prescott, J Bennett, S Semple, S Dick, P Mozzoni, et al. (2007)
Occup. Environ. Med. 64, 673-680
   Abstract »    Full Text »    PDF »
Rapid screening of clarithromycin resistance in Helicobacter pylori by pyrosequencing.
K.-A. Moder, F. Layer, W. Konig, and B. Konig (2007)
J. Med. Microbiol. 56, 1370-1376
   Abstract »    Full Text »    PDF »
Rapid Identification of Promoter Hypermethylation in Hepatocellular Carcinoma by Pyrosequencing of Etiologically Homogeneous Sample Pools.
E. Dejeux, V. Audard, C. Cavard, I. G. Gut, B. Terris, and J. Tost (2007)
J. Mol. Diagn. 9, 510-520
   Abstract »    Full Text »    PDF »
Multigene amplification and massively parallel sequencing for cancer mutation discovery.
F. Dahl, J. Stenberg, S. Fredriksson, K. Welch, M. Zhang, M. Nilsson, D. Bicknell, W. F. Bodmer, R. W. Davis, and H. Ji (2007)
PNAS 104, 9387-9392
   Abstract »    Full Text »    PDF »
More on Contamination: The Use of Asymmetric Molecular Behavior to Identify Authentic Ancient Human DNA.
H. Malmstrom, E. M. Svensson, M. T. P. Gilbert, E. Willerslev, A. Gotherstrom, and G. Holmlund (2007)
Mol. Biol. Evol. 24, 998-1004
   Abstract »    Full Text »    PDF »
Identification of Alpha-Hemolytic Streptococci by Pyrosequencing the 16S rRNA Gene and by Use of VITEK 2.
M. Haanpera, J. Jalava, P. Huovinen, O. Meurman, and K. Rantakokko-Jalava (2007)
J. Clin. Microbiol. 45, 762-770
   Abstract »    Full Text »    PDF »
Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators.
J. Ju, D. H. Kim, L. Bi, Q. Meng, X. Bai, Z. Li, X. Li, M. S. Marma, S. Shi, J. Wu, et al. (2006)
PNAS 103, 19635-19640
   Abstract »    Full Text »    PDF »
A Sanger/pyrosequencing hybrid approach for the generation of high-quality draft assemblies of marine microbial genomes.
S. M. D. Goldberg, J. Johnson, D. Busam, T. Feldblyum, S. Ferriera, R. Friedman, A. Halpern, H. Khouri, S. A. Kravitz, F. M. Lauro, et al. (2006)
PNAS 103, 11240-11245
   Abstract »    Full Text »    PDF »
Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis by Pyrosequencing Technology..
P. Jureen, L. Engstrand, S. Eriksson, A. Alderborn, M. Krabbe, and S. E. Hoffner (2006)
J. Clin. Microbiol. 44, 1925-1929
   Abstract »    Full Text »    PDF »
Quantitative Analysis of SRNPN Gene Methylation by Pyrosequencing as a Diagnostic Test for Prader-Willi Syndrome and Angelman Syndrome.
H. E. White, V. J. Durston, J. F. Harvey, and N. C.P. Cross (2006)
Clin. Chem. 52, 1005-1013
   Abstract »    Full Text »    PDF »
Streptococcus pneumoniae Isolates Resistant to Telithromycin..
M. Rantala, M. Haanpera-Heikkinen, M. Lindgren, H. Seppala, P. Huovinen, J. Jalava, and the Finnish Study Group for Antimicrobial Resistan (2006)
Antimicrob. Agents Chemother. 50, 1855-1858
   Abstract »    Full Text »    PDF »
DNA sequence variation in the promoter region of the VEGF gene impacts VEGF gene expression and maximal oxygen consumption.
S. J. Prior, J. M. Hagberg, C. M. Paton, L. W. Douglass, M. D. Brown, J. C. McLenithan, and S. M. Roth (2006)
Am J Physiol Heart Circ Physiol 290, H1848-H1855
   Abstract »    Full Text »    PDF »
Emerging technologies in DNA sequencing.
M. L. Metzker (2005)
Genome Res. 15, 1767-1776
   Abstract »    Full Text »    PDF »
An analysis of the feasibility of short read sequencing.
N. Whiteford, N. Haslam, G. Weber, A. Prugel-Bennett, J. W. Essex, P. L. Roach, M. Bradley, and C. Neylon (2005)
Nucleic Acids Res. 33, e171
   Abstract »    Full Text »    PDF »
New Quinolone Resistance Phenomenon in Salmonella enterica: Nalidixic Acid-Susceptible Isolates with Reduced Fluoroquinolone Susceptibility.
A. J. Hakanen, M. Lindgren, P. Huovinen, J. Jalava, A. Siitonen, and P. Kotilainen (2005)
J. Clin. Microbiol. 43, 5775-5778
   Abstract »    Full Text »    PDF »
Prevalence and Molecular Genetics of Macrolide Resistance among Streptococcus pneumoniae Isolates Collected in Finland in 2002.
M. Rantala, S. Huikko, P. Huovinen, J. Jalava, and the Finnish Study Group for Antimicrobial Resistan (2005)
Antimicrob. Agents Chemother. 49, 4180-4184
   Abstract »    Full Text »    PDF »
Estimating RNA editing efficiency of five editing sites in the serotonin 2C receptor by pyrosequencing.
K. IWAMOTO, M. BUNDO, and T. KATO (2005)
RNA 11, 1596-1603
   Abstract »    Full Text »    PDF »
Multiplex SNP typing by bioluminometric assay coupled with terminator incorporation (BATI).
G.-H. Zhou, M. Gotou, T. Kajiyama, and H. Kambara (2005)
Nucleic Acids Res. 33, e133
   Abstract »    Full Text »    PDF »
Discovery of SNPs in Soybean Genotypes Frequently Used as the Parents of Mapping Populations in the United States and Korea.
K. Van, E.-Y. Hwang, M. Y. Kim, H. J. Park, S.-H. Lee, and P. B. Cregan (2005)
J. Hered. 96, 529-535
   Abstract »    Full Text »    PDF »
Two-Step Genetic Screening of Thrombophilia by Pyrosequencing.
A. Verri, F. Focher, G. Tettamanti, and V. Grazioli (2005)
Clin. Chem. 51, 1282-1284
   Full Text »    PDF »
Prehistoric contacts over the Straits of Gibraltar indicated by genetic analysis of Iberian Bronze Age cattle.
C. Anderung, A. Bouwman, P. Persson, J. M. Carretero, A. I. Ortega, R. Elburg, C. Smith, J. L. Arsuaga, H. Ellegren, and A. Gotherstrom (2005)
PNAS 102, 8431-8435
   Abstract »    Full Text »    PDF »
Four-color DNA sequencing by synthesis on a chip using photocleavable fluorescent nucleotides.
T. S. Seo, X. Bai, D. H. Kim, Q. Meng, S. Shi, H. Ruparel, Z. Li, N. J. Turro, and J. Ju (2005)
PNAS 102, 5926-5931
   Abstract »    Full Text »    PDF »
Competitive enzymatic reaction to control allele-specific extensions.
E. Hultin, M. Kaller, A. Ahmadian, and J. Lundeberg (2005)
Nucleic Acids Res. 33, e48
   Abstract »    Full Text »    PDF »
Determination of CYP2D6 Gene Copy Number by Pyrosequencing.
E. Soderback, A.-L. Zackrisson, B. Lindblom, and A. Alderborn (2005)
Clin. Chem. 51, 522-531
   Abstract »    Full Text »    PDF »
Detection of Aspergillus fumigatus and a Mutation That Confers Reduced Susceptibility to Itraconazole and Posaconazole by Real-Time PCR and Pyrosequencing.
J. P. Trama, E. Mordechai, and M. E. Adelson (2005)
J. Clin. Microbiol. 43, 906-908
   Abstract »    Full Text »    PDF »
Detection and Quantification of Macrolide Resistance Mutations at Positions 2058 and 2059 of the 23S rRNA Gene by Pyrosequencing.
M. Haanpera, P. Huovinen, and J. Jalava (2005)
Antimicrob. Agents Chemother. 49, 457-460
   Abstract »    Full Text »    PDF »
A multi-enzyme model for pyrosequencing.
A. Agah, M. Aghajan, F. Mashayekhi, S. Amini, R. W. Davis, J. D. Plummer, M. Ronaghi, and P. B. Griffin (2004)
Nucleic Acids Res. 32, e166
   Abstract »    Full Text »    PDF »
Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.
H. Hochstrasser, P. Bauer, U. Walter, S. Behnke, J. Spiegel, I. Csoti, B. Zeiler, A. Bornemann, J. Pahnke, G. Becker, et al. (2004)
Neurology 63, 1912-1917
   Abstract »    Full Text »    PDF »
Analytical Validation of the Tag-It High-Throughput Microsphere-Based Universal Array Genotyping Platform: Application to the Multiplex Detection of a Panel of Thrombophilia-Associated Single-Nucleotide Polymorphisms.
S. Bortolin, M. Black, H. Modi, I. Boszko, D. Kobler, D. Fieldhouse, E. Lopes, J.-M. Lacroix, R. Grimwood, P. Wells, et al. (2004)
Clin. Chem. 50, 2028-2036
   Abstract »    Full Text »    PDF »
Pyrosequencing for Detection of Lamivudine-Resistant Hepatitis B Virus.
A. Lindstrom, J. Odeberg, and J. Albert (2004)
J. Clin. Microbiol. 42, 4788-4795
   Abstract »    Full Text »    PDF »
Characterization of synthetic DNA bar codes in Saccharomyces cerevisiae gene-deletion strains.
R. G. Eason, N. Pourmand, W. Tongprasit, Z. S. Herman, K. Anthony, O. Jejelowo, R. W. Davis, and V. Stolc (2004)
PNAS 101, 11046-11051
   Abstract »    Full Text »    PDF »
Molecular Typing of Neisseria gonorrhoeae Isolates by Pyrosequencing of Highly Polymorphic Segments of the porB Gene.
M. Unemo, P. Olcen, J. Jonasson, and H. Fredlund (2004)
J. Clin. Microbiol. 42, 2926-2934
   Abstract »    Full Text »    PDF »
Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis.
E. P. Kartalov and S. R. Quake (2004)
Nucleic Acids Res. 32, 2873-2879
   Abstract »    Full Text »    PDF »
Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK.
E. R. Packard, R. Parton, J. G. Coote, and N. K. Fry (2004)
J. Med. Microbiol. 53, 355-365
   Abstract »    Full Text »    PDF »
Photocleavable fluorescent nucleotides for DNA sequencing on a chip constructed by site-specific coupling chemistry.
T. S. Seo, X. Bai, H. Ruparel, Z. Li, N. J. Turro, and J. Ju (2004)
PNAS 101, 5488-5493
   Abstract »    Full Text »    PDF »
Discrimination between Scrapie and Bovine Spongiform Encephalopathy in Sheep by Molecular Size, Immunoreactivity, and Glycoprofile of Prion Protein.
C. M. A. Thuring, J. H. F. Erkens, J. G. Jacobs, A. Bossers, L. J. M. Van Keulen, G. J. Garssen, F. G. Van Zijderveld, S. J. Ryder, M. H. Groschup, T. Sweeney, et al. (2004)
J. Clin. Microbiol. 42, 972-980
   Abstract »    Full Text »    PDF »
Digital Detection of Genetic Mutations Using SPC-Sequencing.
H. Ruparel, M. E. Ulz, S. Kim, and J. Ju (2004)
Genome Res. 14, 296-300
   Abstract »    Full Text »    PDF »
Rapid Detection and Estimation by Pyrosequencing of 23S rRNA Genes with a Single Nucleotide Polymorphism Conferring Linezolid Resistance in Enterococci.
A. Sinclair, C. Arnold, and N. Woodford (2003)
Antimicrob. Agents Chemother. 47, 3620-3622
   Abstract »    Full Text »    PDF »
Comparison of Serologic and Genetic porB-Based Typing of Neisseria gonorrhoeae: Consequences for Future Characterization.
M. Unemo, P. Olcen, J. Albert, and H. Fredlund (2003)
J. Clin. Microbiol. 41, 4141-4147
   Abstract »    Full Text »    PDF »
Single base extension (SBE) with proofreading polymerases and phosphorothioate primers: improved fidelity in single-substrate assays.
D. Di Giusto and G. C. King (2003)
Nucleic Acids Res. 31, e7
   Abstract »    Full Text »    PDF »
A photocleavable fluorescent nucleotide for DNA sequencing and analysis.
Z. Li, X. Bai, H. Ruparel, S. Kim, N. J. Turro, and J. Ju (2003)
PNAS 100, 414-419
   Abstract »    Full Text »    PDF »
NotI passporting to identify species composition of complex microbial systems.
V. Zabarovska, A. S. Kutsenko, L. Petrenko, G. Kilosanidze, O. Ljungqvist, E. Norin, T. Midtvedt, G. Winberg, R. Mollby, V. I. Kashuba, et al. (2003)
Nucleic Acids Res. 31, e5
   Abstract »    Full Text »    PDF »
A Nonsense Mutation in the FMO3 Gene Underlies Fishy Off-Flavor in Cow's Milk.
A. Lunden, S. Marklund, V. Gustafsson, and L. Andersson (2002)
Genome Res. 12, 1885-1888
   Abstract »    Full Text »    PDF »
hairy: A Quantitative Trait Locus for Drosophila Sensory Bristle Number.
C. Robin, R. F. Lyman, A. D. Long, C. H. Langley, and T. F. C. Mackay (2002)
Genetics 162, 155-164
   Abstract »    Full Text »    PDF »
Bioluminescent Method for Detecting Telomerase Activity.
S.-Q. Xu, M. He, H.-P. Yu, X.-Y. Wang, X.-L. Tan, B. Lu, X. Sun, Y.-K. Zhou, Q.-F. Yao, Y.-J. Xu, et al. (2002)
Clin. Chem. 48, 1016-1020
   Abstract »    Full Text »    PDF »
Infusion of CD4+ Donor Lymphocytes Induces the Expansion of CD8+ Donor T Cells with Cytolytic Activity Directed against Recipient Hematopoietic Cells.
E. Zorn, K. S. Wang, E. P. Hochberg, C. Canning, E. P. Alyea, R. J. Soiffer, and J. Ritz (2002)
Clin. Cancer Res. 8, 2052-2060
   Abstract »    Full Text »    PDF »
Multiplex Pyrosequencing.
N. Pourmand, E. Elahi, R. W. Davis, and M. Ronaghi (2002)
Nucleic Acids Res. 30, e31
   Abstract »    Full Text »    PDF »
A new approach to genome mapping and sequencing: slalom libraries.
V. I. Zabarovska, R. Z. Gizatullin, A. N. Al-Amin, R. Podowski, A. I. Protopopov, S. Lofdahl, C. Wahlestedt, G. Winberg, V. I. Kashuba, I. Ernberg, et al. (2002)
Nucleic Acids Res. 30, e6
   Abstract »    Full Text »    PDF »
Unexpectedly High Allelic Diversity at the KIT Locus Causing Dominant White Color in the Domestic Pig.
G. Pielberg, C. Olsson, A.-C. Syvanen, and L. Andersson (2002)
Genetics 160, 305-311
   Abstract »    Full Text »    PDF »
Genotyping by apyrase-mediated allele-specific extension.
A. Ahmadian, B. Gharizadeh, D. O'Meara, J. Odeberg, and J. Lundeberg (2001)
Nucleic Acids Res. 29, e121
   Abstract »    Full Text »    PDF »
L-RCA (ligation-rolling circle amplification): a general method for genotyping of single nucleotide polymorphisms (SNPs).
X. Qi, S. Bakht, K. M. Devos, M. D. Gale, and A. Osbourn (2001)
Nucleic Acids Res. 29, e116
   Abstract »    Full Text »    PDF »
Pyrosequencing as a Method for Grouping of Listeria monocytogenes Strains on the Basis of Single-Nucleotide Polymorphisms in the inlB Gene.
H. Unnerstad, H. Ericsson, A. Alderborn, W. Tham, M.-L. Danielsson-Tham, and J. G. Mattsson (2001)
Appl. Envir. Microbiol. 67, 5339-5342
   Abstract »    Full Text »
Quantitative detection of single nucleotide polymorphisms for a pooled sample by a bioluminometric assay coupled with modified primer extension reactions (BAMPER).
G.-h. Zhou, M. Kamahori, K. Okano, G. Chuan, K. Harada, and H. Kambara (2001)
Nucleic Acids Res. 29, e93
   Abstract »    Full Text »    PDF »
Monitoring Resistance to Human Immunodeficiency Virus Type 1 Protease Inhibitors by Pyrosequencing.
D. O'Meara, K. Wilbe, T. Leitner, B. Hejdeman, J. Albert, and J. Lundeberg (2001)
J. Clin. Microbiol. 39, 464-473
   Abstract »    Full Text »
Pyrosequencing Sheds Light on DNA Sequencing.
M. Ronaghi (2001)
Genome Res. 11, 3-11
   Abstract »    Full Text »
Automation for Genomics, Part Two: Sequencers, Microarrays, and Future Trends.
D. Meldrum (2000)
Genome Res. 10, 1288-1303
   Abstract »    Full Text »
Determination of Single-Nucleotide Polymorphisms by Real-time Pyrophosphate DNA Sequencing.
A. Alderborn, A. Kristofferson, and U. Hammerling (2000)
Genome Res. 10, 1249-1258
   Abstract »    Full Text »
A Mutation in PRKAG3 Associated with Excess Glycogen Content in Pig Skeletal Muscle.
D. Milan, J. Jeon, C. Looft, V. Amarger, A. Robic, M. Thelander, C. Rogel-Gaillard, S. Paul, N. Iannuccelli, L. Rask, et al. (2000)
Science 288, 1248-1251
   Abstract »    Full Text »
Production by quantitative photolithographic synthesis of individually quality checked DNA microarrays.
M. Beier and J. D. Hoheisel (2000)
Nucleic Acids Res. 28, e11
   Abstract »    Full Text »    PDF »
Polymorphism in the Pertussis Toxin Promoter Region Affecting the DNA-Based Diagnosis of Bordetella Infection.
M. Nygren, E. Reizenstein, M. Ronaghi, and J. Lundeberg (2000)
J. Clin. Microbiol. 38, 55-60
   Abstract »    Full Text »
Molecular grouping of Listeria monocytogenes based on the sequence of the inlB gene.
H. ERICSSON, H. UNNERSTAD, J. G. MATTSSON, M.-L. DANIELSSON-THAM, and W. THAM (2000)
J. Med. Microbiol. 49, 73-80
   Abstract »    Full Text »    PDF »
Gene discovery in the wood-forming tissues of poplar: Analysis of 5,692 expressed sequence tags.
F. Sterky, S. Regan, J. Karlsson, M. Hertzberg, A. Rohde, A. Holmberg, B. Amini, R. Bhalerao, M. Larsson, R. Villarroel, et al. (1998)
PNAS 95, 13330-13335
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)