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Science 10 July 1998:
Vol. 281. no. 5374, pp. 185 - 186
DOI: 10.1126/science.281.5374.185
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Perspectives

Also see the archival list of Science's Compass: Enhanced: Perspectives

CELL CYCLE:
Enhanced: Rad9 Comes of Age

Nancy C. Walworth

When their genetic material is damaged, cells prudently refrain from starting cell division (or mitosis). A prominent component of the cellular machinery that puts this brake on the cell, the protein Rad9, has now been identified by Sun et al. Walworth explains in her Perspective how this work now suggests a mechanism by which Rad9 and another protein Rad53 stop the cell cycle.

The author is at the Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, USA. E-mail: walworna{at}umdnj.edu

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