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Science 26 June 1998:
Vol. 280. no. 5372, pp. 2121 - 2126
DOI: 10.1126/science.280.5372.2121
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Reports

Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade

Clifford Kentros, * Eric Hargreaves, Robert D. Hawkins, Eric R. Kandel, Matthew Shapiro, Robert V. Muller dagger

Hippocampal pyramidal cells are called place cells because each cell tends to fire only when the animal is in a particular part of the environment--the cell's firing field. Acute pharmacological blockade of N-methyl-D-aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields. The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation. By contrast, the long-term stabilization of newly established firing fields required normal NMDA receptor function and, therefore, may be related to other NMDA-dependent processes such as long-term potentiation and spatial learning.

C. Kentros, Department of Physiology, SUNY Health Science Center Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
E. Hargreaves and M. Shapiro, Department of Psychology, McGill University, 1205 Doctor Penfield Avenue, Montreal, QC H3A1B1, Canada.
R. D. Hawkins, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, 722 West 168 Street, New York, NY 10032, USA.
E. R. Kandel, Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, 722 West 168 Street, New York, NY 10032, USA.
R. V. Muller, Department of Physiology, SUNY Health Science Center Brooklyn, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
*   Present address: Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 722 West 168 Street, New York, NY 10032, USA.

dagger    To whom correspondence should be addressed. E-mail: bob{at}fasthp.hippo.hscbklyn.edu

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