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Science 26 June 1998:
Vol. 280. no. 5372, pp. 2118 - 2121
DOI: 10.1126/science.280.5372.2118
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Reports

Drosophila Synapse Formation: Regulation by Transmembrane Protein with Leu-Rich Repeats, CAPRICIOUS

Emiko Shishido, Masatoshi Takeichi, Akinao Nose *dagger

Upon reaching the target region, neuronal growth cones transiently search through potential targets and form synaptic connections with only a subset of these. The capricious (caps) gene may regulate these processes in Drosophila. caps encodes a transmembrane protein with leucine-rich repeats (LRRs). During the formation of neuromuscular synapses, caps is expressed in a small number of synaptic partners, including muscle 12 and the motorneurons that innervate it. Loss-of-function and ectopic expression of caps alter the target specificity of muscle 12 motorneurons, indicating a role for caps in selective synapse formation.

E. Shishido and A. Nose, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan.
M. Takeichi, Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Kyoto 606-8502, Japan.
*   To whom correspondence should be addressed. E-mail: nose{at}bio.phys.s.u-tokyo.ac.jp

dagger    Present address: Department of Physics, School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan.

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