Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
GoGreen Membership

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 June 1998:
Vol. 280. no. 5372, pp. 2109 - 2111
DOI: 10.1126/science.280.5372.2109
Prev | Table of Contents | Next

Reports

p115 RhoGEF, a GTPase Activating Protein for Galpha 12 and Galpha 13

Tohru Kozasa, * Xuejun Jiang, Matthew J. Hart, Pamela M. Sternweis, William D. Singer, Alfred G. Gilman, Gideon Bollag, * Paul C. Sternweis *

Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the alpha  subunits of certain heterotrimeric guanine nucleotide-binding proteins (G proteins). The guanine nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino-terminal region with similarity to RGS proteins. Recombinant p115 RhoGEF and a fusion protein containing the amino terminus of p115 had specific activity as GTPase activating proteins toward the alpha  subunits of the G proteins G12 and G13, but not toward members of the Gs, Gi, or Gq subfamilies of Galpha proteins. This GEF may act as an intermediary in the regulation of Rho proteins by G13 and G12.

T. Kozasa, X. Jiang, P. M. Sternweis, W. D. Singer, A. G. Gilman, P. C. Sternweis, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
M. J. Hart and G. Bollag, Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA.
*   To whom correspondence should be addressed. E-mail: tohru.kozasa{at}email.swmed.edu (T.K.), bollag{at}onyx-pharm.com (G.B.), and sternwei{at}utsw.swmed.edu (P.C.S.).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling.
X. Huang, D. Wu, H. Jin, D. Stupack, and J. Y.J. Wang (2008)
J. Cell Biol. 183, 711-723
   Abstract »    Full Text »    PDF »
Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from G{alpha}12/13 and G{alpha}11/q.
J. Gavard and J. S. Gutkind (2008)
J. Biol. Chem. 283, 29888-29896
   Abstract »    Full Text »    PDF »
Dual Activation of Phospholipase C-{epsilon} by Rho and Ras GTPases.
J. P. Seifert, Y. Zhou, S. N. Hicks, J. Sondek, and T. K. Harden (2008)
J. Biol. Chem. 283, 29690-29698
   Abstract »    Full Text »    PDF »
Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.
A. Maekawa, Y. Kanaoka, W. Xing, and K. F. Austen (2008)
PNAS 105, 16695-16700
   Abstract »    Full Text »    PDF »
Regulation of cAMP Responses by the G12/13 Pathway Converges on Adenylyl Cyclase VII.
L. I. Jiang, J. Collins, R. Davis, I. D. Fraser, and P. C. Sternweis (2008)
J. Biol. Chem. 283, 23429-23439
   Abstract »    Full Text »    PDF »
Thrombin Induces Fibroblast CCL2/JE Production and Release via Coupling of PAR1 to G{alpha}q and Cooperation between ERK1/2 and Rho Kinase Signaling Pathways.
X. Deng, P. F. Mercer, C. J. Scotton, A. Gilchrist, and R. C. Chambers (2008)
Mol. Biol. Cell 19, 2520-2533
   Abstract »    Full Text »    PDF »
Molecular architecture of G{alpha}o and the structural basis for RGS16-mediated deactivation.
K. C. Slep, M. A. Kercher, T. Wieland, C.-K. Chen, M. I. Simon, and P. B. Sigler (2008)
PNAS 105, 6243-6248
   Abstract »    Full Text »    PDF »
Inhibition of Human Neutrophil Chemotaxis by Endogenous Cannabinoids and Phytocannabinoids: Evidence for a Site Distinct from CB1 and CB2.
D. McHugh, C. Tanner, R. Mechoulam, R. G. Pertwee, and R. A. Ross (2008)
Mol. Pharmacol. 73, 441-450
   Abstract »    Full Text »    PDF »
Heterotrimeric G Protein {gamma} Subunits Stimulate FLJ00018, a Guanine Nucleotide Exchange Factor for Rac1 and Cdc42.
H. Ueda, R. Nagae, M. Kozawa, R. Morishita, S. Kimura, T. Nagase, O. Ohara, S. Yoshida, and T. Asano (2008)
J. Biol. Chem. 283, 1946-1953
   Abstract »    Full Text »    PDF »
Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.
P. Uawithya, T. Pisitkun, B. E. Ruttenberg, and M. A. Knepper (2008)
Physiol Genomics 32, 229-253
   Abstract »    Full Text »    PDF »
Structure of G{alpha}q-p63RhoGEF-RhoA Complex Reveals a Pathway for the Activation of RhoA by GPCRs.
S. Lutz, A. Shankaranarayanan, C. Coco, M. Ridilla, M. R. Nance, C. Vettel, D. Baltus, C. R. Evelyn, R. R. Neubig, T. Wieland, et al. (2007)
Science 318, 1923-1927
   Abstract »    Full Text »    PDF »
Dual Regulation of Endothelial Junctional Permeability.
Y. A. Komarova, D. Mehta, and A. B. Malik (2007)
Sci. STKE 2007, re8
   Abstract »    Full Text »    PDF »
Disruption of Oligomerization Induces Nucleocytoplasmic Shuttling of Leukemia-Associated Rho Guanine-Nucleotide Exchange Factor.
E. Grabocka and P. B. Wedegaertner (2007)
Mol. Pharmacol. 72, 993-1002
   Abstract »    Full Text »    PDF »
GDI-1 Phosphorylation Switch at Serine 96 Induces RhoA Activation and Increased Endothelial Permeability.
N. Knezevic, A. Roy, B. Timblin, M. Konstantoulaki, T. Sharma, A. B. Malik, and D. Mehta (2007)
Mol. Cell. Biol. 27, 6323-6333
   Abstract »    Full Text »    PDF »
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.
C. R. Evelyn, S. M. Wade, Q. Wang, M. Wu, J. A. Iniguez-Lluhi, S. D. Merajver, and R. R. Neubig (2007)
Mol. Cancer Ther. 6, 2249-2260
   Abstract »    Full Text »    PDF »
Lysophosphatidic Acid Regulates Trafficking of beta2-Adrenergic Receptors: THE G{alpha}13/p115RhoGEF/JNK PATHWAY STIMULATES RECEPTOR INTERNALIZATION.
E. Shumay, J. Tao, H.-y. Wang, and C. C. Malbon (2007)
J. Biol. Chem. 282, 21529-21541
   Abstract »    Full Text »    PDF »
Gbeta{gamma}-mediated Prostacyclin Production and cAMP-dependent Protein Kinase Activation by Endothelin-1 Promotes Vascular Smooth Muscle Cell Hypertrophy through Inhibition of Glycogen Synthase Kinase-3.
S. Taurin, K. Hogarth, N. Sandbo, D. M. Yau, and N. O. Dulin (2007)
J. Biol. Chem. 282, 19518-19525
   Abstract »    Full Text »    PDF »
Arhgef1 Is Required by T Cells for the Development of Airway Hyperreactivity and Inflammation.
J. P. Brown, C. Taube, N. Miyahara, T. Koya, R. Pelanda, E. W. Gelfand, and R. M. Torres (2007)
Am. J. Respir. Crit. Care Med. 176, 10-19
   Abstract »    Full Text »    PDF »
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates {alpha}1 adrenergic receptor-induced cardiomyocyte hypertrophy.
A. Appert-Collin, S. Cotecchia, M. Nenniger-Tosato, T. Pedrazzini, and D. Diviani (2007)
PNAS 104, 10140-10145
   Abstract »    Full Text »    PDF »
Somatostatin Receptors Signal through EFA6A-ARF6 to Activate Phospholipase D in Clonal beta-Cells.
J. A. Grodnitzky, N. Syed, M. J. Kimber, T. A. Day, J. G. Donaldson, and W. H. Hsu (2007)
J. Biol. Chem. 282, 13410-13418
   Abstract »    Full Text »    PDF »
The P2Y2 nucleotide receptor requires interaction with {alpha}v integrins to access and activate G12.
Z. Liao, C. I. Seye, G. A. Weisman, and L. Erb (2007)
J. Cell Sci. 120, 1654-1662
   Abstract »    Full Text »    PDF »
Domains Necessary for G{alpha}12 Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is G{alpha}12 a Novel Regulatory Subunit of PP2A?.
D. Zhu, R. I. Tate, R. Ruediger, T. E. Meigs, and B. M. Denker (2007)
Mol. Pharmacol. 71, 1268-1276
   Abstract »    Full Text »    PDF »
G{alpha}q-TRPC6-mediated Ca2+ Entry Induces RhoA Activation and Resultant Endothelial Cell Shape Change in Response to Thrombin.
I. Singh, N. Knezevic, G. U. Ahmmed, V. Kini, A. B. Malik, and D. Mehta (2007)
J. Biol. Chem. 282, 7833-7843
   Abstract »    Full Text »    PDF »
LPA4/p2y9/GPR23 Mediates Rho-dependent Morphological Changes in a Rat Neuronal Cell Line.
K. Yanagida, S. Ishii, F. Hamano, K. Noguchi, and T. Shimizu (2007)
J. Biol. Chem. 282, 5814-5824
   Abstract »    Full Text »    PDF »
LPA4/GPR23 Is a Lysophosphatidic Acid (LPA) Receptor Utilizing Gs-, Gq/Gi-mediated Calcium Signaling and G12/13-mediated Rho Activation.
C.-W. Lee, R. Rivera, A. E. Dubin, and J. Chun (2007)
J. Biol. Chem. 282, 4310-4317
   Abstract »    Full Text »    PDF »
Neurokinin 1 Receptors Trigger Overlapping Stimulation and Inhibition of CaV2.3 (R-Type) Calcium Channels.
U. Meza, A. Thapliyal, R. A. Bannister, and B. A. Adams (2007)
Mol. Pharmacol. 71, 284-293
   Abstract »    Full Text »    PDF »
Direct G Protein Modulation of Cav2 Calcium Channels.
H. W. Tedford and G. W. Zamponi (2006)
Pharmacol. Rev. 58, 837-862
   Abstract »    Full Text »    PDF »
The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF.
A. Oleksy, L/u. Opalinski, U. Derewenda, Z. S. Derewenda, and J. Otlewski (2006)
J. Biol. Chem. 281, 32891-32897
   Abstract »    Full Text »    PDF »
The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with G{alpha}12 but Not G{alpha}13.
L. N. Stemmle, T. A. Fields, and P. J. Casey (2006)
Mol. Pharmacol. 70, 1461-1468
   Abstract »    Full Text »    PDF »
Pleiotropic Phenotype of a Genomic Knock-In of an RGS-Insensitive G184S Gnai2 Allele..
X. Huang, Y. Fu, R. A. Charbeneau, T. L. Saunders, D. K. Taylor, K. D. Hankenson, M. W. Russell, L. G. D'Alecy, and R. R. Neubig (2006)
Mol. Cell. Biol. 26, 6870-6879
   Abstract »    Full Text »    PDF »
Dynamic Regulation of Mammalian Numb by G Protein-coupled Receptors and Protein Kinase C Activation: Structural Determinants of Numb Association with the Cortical Membrane.
S. E. Dho, J. Trejo, D. P. Siderovski, and C. J. McGlade (2006)
Mol. Biol. Cell 17, 4142-4155
   Abstract »    Full Text »    PDF »
Endothelin 1 Stimulates {beta}1Pix-Dependent Activation of Cdc42 Through the Gs{alpha} Pathway..
A. Chahdi and A. Sorokin (2006)
Experimental Biology and Medicine 231, 761-765
   Abstract »    Full Text »    PDF »
G{alpha}12/13- and Rho-Dependent Activation of Phospholipase C-{epsilon} by Lysophosphatidic Acid and Thrombin Receptors.
M. D. Hains, M. R. Wing, S. Maddileti, D. P. Siderovski, and T. K. Harden (2006)
Mol. Pharmacol. 69, 2068-2075
   Abstract »    Full Text »    PDF »
A Functional Tyr1306Cys Variant in LARG Is Associated With Increased Insulin Action in Vivo..
P. Kovacs, M. Stumvoll, C. Bogardus, R. L. Hanson, and L. J. Baier (2006)
Diabetes 55, 1497-1503
   Abstract »    Full Text »    PDF »
Rho Family Guanine Nucleotide Exchange Factor Brx Couples Extracellular Signals to the Glucocorticoid Signaling System.
T. Kino, E. Souvatzoglou, E. Charmandari, T. Ichijo, P. Driggers, C. Mayers, A. Alatsatianos, I. Manoli, H. Westphal, G. P. Chrousos, et al. (2006)
J. Biol. Chem. 281, 9118-9126
   Abstract »    Full Text »    PDF »
The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits.
J. H. Brown, D. P. Del Re, and M. A. Sussman (2006)
Circ. Res. 98, 730-742
   Abstract »    Full Text »    PDF »
Physiological role of ROCKs in the cardiovascular system.
K. Noma, N. Oyama, and J. K. Liao (2006)
Am J Physiol Cell Physiol 290, C661-C668
   Abstract »    Full Text »    PDF »
Novel Mechanisms of G Protein-Dependent Regulation of Endothelial Nitric-Oxide Synthase.
A. V. Andreeva, R. Vaiskunaite, M. A. Kutuzov, J. Profirovic, R. A. Skidgel, and T. Voyno-Yasenetskaya (2006)
Mol. Pharmacol. 69, 975-982
   Abstract »    Full Text »    PDF »
Angiotensin II Up-Regulates the Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (RhoGEF), a Regulator of G Protein Signaling Domain-Containing RhoGEF, in Vascular Smooth Muscle Cells.
Z. Ying, L. Jin, T. Palmer, and R. C. Webb (2006)
Mol. Pharmacol. 69, 932-940
   Abstract »    Full Text »    PDF »
Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.
S. A. Francis, X. Shen, J. B. Young, P. Kaul, and D. J. Lerner (2006)
Blood 107, 1627-1635
   Abstract »    Full Text »    PDF »
Differential Sensitivity of P-Rex1 to Isoforms of G Protein beta{gamma} Dimers.
L. H. Mayeenuddin, W. E. McIntire, and J. C. Garrison (2006)
J. Biol. Chem. 281, 1913-1920
   Abstract »    Full Text »    PDF »
Signaling Mechanisms Regulating Endothelial Permeability.
D. Mehta and A. B. Malik (2006)
Physiol Rev 86, 279-367
   Abstract »    Full Text »    PDF »
G{alpha}12/13 Is Essential for Directed Cell Migration and Localized Rho-Dia1 Function.
P. Goulimari, T. M. Kitzing, H. Knieling, D. T. Brandt, S. Offermanns, and R. Grosse (2005)
J. Biol. Chem. 280, 42242-42251
   Abstract »    Full Text »    PDF »
Radixin Stimulates Rac1 and Ca2+/Calmodulin-dependent Kinase, CaMKII: CROSS-TALK WITH G{alpha}13 SIGNALING.
G. Liu and T. A. Voyno-Yasenetskaya (2005)
J. Biol. Chem. 280, 39042-39049
   Abstract »    Full Text »    PDF »
Pasteurella multocida Toxin-induced Activation of RhoA Is Mediated via Two Families of G{alpha} Proteins, G{alpha}q and G{alpha}12/13.
J. H. C. Orth, S. Lang, M. Taniguchi, and K. Aktories (2005)
J. Biol. Chem. 280, 36701-36707
   Abstract »    Full Text »    PDF »
Mammalian G Proteins and Their Cell Type Specific Functions.
N. Wettschureck and S. Offermanns (2005)
Physiol Rev 85, 1159-1204
   Abstract »    Full Text »    PDF »
Heterotrimeric G Proteins and the Platelet-Derived Growth Factor Receptor-{beta} Contribute to Hypoxic Proliferation of Smooth Muscle Cells.
M. C. Lanner, M. Raper, W. M. Pratt, and R. A. Rhoades (2005)
Am. J. Respir. Cell Mol. Biol. 33, 412-419
   Abstract »    Full Text »    PDF »
Mechanical force-activated phospholipase D is mediated by G{alpha}12/13-Rho and calmodulin-dependent kinase in renal epithelial cells.
J. Ziembicki, R. Tandon, J. R. Schelling, J. R. Sedor, R. T. Miller, and C. Huang (2005)
Am J Physiol Renal Physiol 289, F826-F834
   Abstract »    Full Text »    PDF »
A Novel Mechanism of G Protein-dependent Phosphorylation of Vasodilator-stimulated Phosphoprotein.
J. Profirovic, M. Gorovoy, J. Niu, S. Pavlovic, and T. Voyno-Yasenetskaya{paragraph} (2005)
J. Biol. Chem. 280, 32866-32876
   Abstract »    Full Text »    PDF »
folded gastrulation, cell shape change and the control of myosin localization.
R. E. Dawes-Hoang, K. M. Parmar, A. E. Christiansen, C. B. Phelps, A. H. Brand, and E. F. Wieschaus (2005)
Development 132, 4165-4178
   Abstract »    Full Text »    PDF »
Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.
H. He, J. Pannequin, J.-P. Tantiongco, A. Shulkes, and G. S. Baldwin (2005)
Am J Physiol Gastrointest Liver Physiol 289, G478-G488
   Abstract »    Full Text »    PDF »
G{alpha}12 Interaction with {alpha}SNAP Induces VE-cadherin Localization at Endothelial Junctions and Regulates Barrier Function.
A. V. Andreeva, M. A. Kutuzov, R. Vaiskunaite, J. Profirovic, T. E. Meigs, S. Predescu, A. B. Malik, and T. Voyno-Yasenetskaya (2005)
J. Biol. Chem. 280, 30376-30383
   Abstract »    Full Text »    PDF »
Lysophosphatidylcholine: an enigmatic lysolipid.
D. Mehta (2005)
Am J Physiol Lung Cell Mol Physiol 289, L174-L175
   Full Text »    PDF »
Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1.
J. N. McLaughlin, L. Shen, M. Holinstat, J. D. Brooks, E. DiBenedetto, and H. E. Hamm (2005)
J. Biol. Chem. 280, 25048-25059
   Abstract »    Full Text »    PDF »
G{alpha}12/13-mediated Production of Reactive Oxygen Species Is Critical for Angiotensin Receptor-induced NFAT Activation in Cardiac Fibroblasts.
T. Fujii, N. Onohara, Y. Maruyama, S. Tanabe, H. Kobayashi, M. Fukutomi, Y. Nagamatsu, N. Nishihara, R. Inoue, H. Sumimoto, et al. (2005)
J. Biol. Chem. 280, 23041-23047
   Abstract »    Full Text »    PDF »
Physical and Functional Interactions of the Lysophosphatidic Acid Receptors with PDZ Domain-containing Rho Guanine Nucleotide Exchange Factors (RhoGEFs).
T. Yamada, Y. Ohoka, M. Kogo, and S. Inagaki (2005)
J. Biol. Chem. 280, 19358-19363
   Abstract »    Full Text »    PDF »
Selective Uncoupling of G{alpha}12 from Rho-mediated Signaling.
T. E. Meigs, J. Juneja, C. T. DeMarco, L. N. Stemmle, D. D. Kaplan, and P. J. Casey (2005)
J. Biol. Chem. 280, 18049-18055
   Abstract »    Full Text »    PDF »
G{alpha}12/13- and Reactive Oxygen Species-dependent Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinase by Angiotensin Receptor Stimulation in Rat Neonatal Cardiomyocytes.
M. Nishida, S. Tanabe, Y. Maruyama, S. Mangmool, K. Urayama, Y. Nagamatsu, S. Takagahara, J. H. Turner, T. Kozasa, H. Kobayashi, et al. (2005)
J. Biol. Chem. 280, 18434-18441
   Abstract »    Full Text »    PDF »
G{alpha}12/G{alpha}13 Subunits of Heterotrimeric G Proteins Mediate Parathyroid Hormone Activation of Phospholipase D in UMR-106 Osteoblastic Cells.
A. T. K. Singh, A. Gilchrist, T. Voyno-Yasenetskaya, J. M. Radeff-Huang, and P. H. Stern (2005)
Endocrinology 146, 2171-2175
   Abstract »    Full Text »    PDF »
Multi-Tasking RGS Proteins in the Heart: The Next Therapeutic Target?.
E. L. Riddle, R. A. Schwartzman, M. Bond, and P. A. Insel (2005)
Circ. Res. 96, 401-411
   Abstract »    Full Text »    PDF »
REGULATORs OF G PROTEIN SIGNALING & DRUGS OF ABUSE.
J. R. Traynor and R. R. Neubig (2005)
Mol. Interv. 5, 30-41
   Abstract »    Full Text »    PDF »
Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.
L. V. Yang, C. G. Radu, L. Wang, M. Riedinger, and O. N. Witte (2005)
Blood 105, 1127-1134
   Abstract »    Full Text »    PDF »
RGS14 Is a Centrosomal and Nuclear Cytoplasmic Shuttling Protein That Traffics to Promyelocytic Leukemia Nuclear Bodies Following Heat Shock.
H. Cho, D.-U. Kim, and J. H. Kehrl (2005)
J. Biol. Chem. 280, 805-814
   Abstract »    Full Text »    PDF »
The role of the Rho GTPases in neuronal development.
E.-E. Govek, S. E. Newey, and L. Van Aelst (2005)
Genes & Dev. 19, 1-49
   Abstract »    Full Text »    PDF »
G{alpha}12 Directly Interacts with PP2A: EVIDENCE FOR G{alpha}12-STIMULATED PP2A PHOSPHATASE ACTIVITY AND DEPHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEIN, Tau.
D. Zhu, K. S. Kosik, T. E. Meigs, V. Yanamadala, and B. M. Denker (2004)
J. Biol. Chem. 279, 54983-54986
   Abstract »    Full Text »    PDF »
Chimeric G{alpha}i2/G{alpha}13 Proteins Reveal the Structural Requirements for the Binding and Activation of the RGS-like (RGL)-containing Rho Guanine Nucleotide Exchange Factors (GEFs) by G{alpha}13.
J. Vazquez-Prado, H. Miyazaki, M. D. Castellone, H. Teramoto, and J. S. Gutkind (2004)
J. Biol. Chem. 279, 54283-54290
   Abstract »    Full Text »    PDF »
G{alpha}13 Signals via p115RhoGEF Cascades Regulating JNK1 and Primitive Endoderm Formation.
Y.-N. Lee, C. C. Malbon, and H.-y. Wang (2004)
J. Biol. Chem. 279, 54896-54904
   Abstract »    Full Text »    PDF »
Integrated control of lung fluid balance.
D. Mehta, J. Bhattacharya, M. A. Matthay, and A. B. Malik (2004)
Am J Physiol Lung Cell Mol Physiol 287, L1081-L1090
   Abstract »    Full Text »    PDF »
G{alpha}13 Stimulates Cell Migration through Cortactin-interacting Protein Hax-1.
V. Radhika, D. Onesime, J. H. Ha, and N. Dhanasekaran (2004)
J. Biol. Chem. 279, 49406-49413
   Abstract »    Full Text »    PDF »
G{alpha}13 Mediates a Signal That Is Essential for Proliferation and Survival of Thymocyte Progenitors.
V. McNeil Coffield, W. S. Helms, Q. Jiang, and L. Su (2004)
J. Exp. Med. 200, 1315-1324
   Abstract »    Full Text »    PDF »
RhoA Activates Purified Phospholipase C-{epsilon} by a Guanine Nucleotide-dependent Mechanism.
J. P. Seifert, M. R. Wing, J. T. Snyder, S. Gershburg, J. Sondek, and T. K. Harden (2004)
J. Biol. Chem. 279, 47992-47997
   Abstract »    Full Text »    PDF »
Inactivation of Rho/ROCK Signaling Is Crucial for the Nuclear Accumulation of FKHR and Myoblast Fusion.
T. Nishiyama, I. Kii, and A. Kudo (2004)
J. Biol. Chem. 279, 47311-47319
   Abstract »    Full Text »    PDF »
Structural Determinants of RhoA Binding and Nucleotide Exchange in Leukemia-associated Rho Guanine-Nucleotide Exchange Factor.
R. Kristelly, G. Gao, and J. J. G. Tesmer (2004)
J. Biol. Chem. 279, 47352-47362
   Abstract »    Full Text »    PDF »
Critical Role of Lysine 204 in Switch I Region of G{alpha}13 for Regulation of p115RhoGEF and Leukemia-Associated RhoGEF.
S. Nakamura, B. Kreutz, S. Tanabe, N. Suzuki, and T. Kozasa (2004)
Mol. Pharmacol. 66, 1029-1034
   Abstract »    Full Text »    PDF »
RGS17/RGSZ2, a Novel Regulator of Gi/o, Gz, and Gq Signaling.
H. Mao, Q. Zhao, M. Daigle, M. H. Ghahremani, P. Chidiac, and P. R. Albert (2004)
J. Biol. Chem. 279, 26314-26322
   Abstract »    Full Text »    PDF »
Toll-Like Receptor Signaling Alters the Expression of Regulator of G Protein Signaling Proteins in Dendritic Cells: Implications for G Protein-Coupled Receptor Signaling.
G.-X. Shi, K. Harrison, S.-B. Han, C. Moratz, and J. H. Kehrl (2004)
J. Immunol. 172, 5175-5184
   Abstract »    Full Text »    PDF »
Lysophosphatidic Acid and Autotaxin Stimulate Cell Motility of Neoplastic and Non-neoplastic Cells through LPA1.
K. Hama, J. Aoki, M. Fukaya, Y. Kishi, T. Sakai, R. Suzuki, H. Ohta, T. Yamori, M. Watanabe, J. Chun, et al. (2004)
J. Biol. Chem. 279, 17634-17639
   Abstract »    Full Text »    PDF »
Identification of a Novel Sequence in PDZ-RhoGEF That Mediates Interaction with the Actin Cytoskeleton.
J. Banerjee and P. B. Wedegaertner (2004)
Mol. Biol. Cell 15, 1760-1775
   Abstract »    Full Text »    PDF »
RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity.
E. D. Gallagher, S. Gutowski, P. C. Sternweis, and M. H. Cobb (2004)
J. Biol. Chem. 279, 1872-1877
   Abstract »    Full Text »    PDF »
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling.
K. Kasai, M. Takahashi, N. Osumi, S. Sinnarajah, T. Takeo, H. Ikeda, J. H. Kehrl, G. Itoh, and H. Arnheiter (2004)
Genes Cells 9, 49-58
   Abstract »    Full Text »    PDF »
The Ca2+-sensing receptor couples to G{alpha}12/13 to activate phospholipase D in Madin-Darby canine kidney cells.
C. Huang, K. M. Hujer, Z. Wu, and R. T. Miller (2004)
Am J Physiol Cell Physiol 286, C22-C30
   Abstract »    Full Text »    PDF »
Thermodynamic Characterization of the Binding of Activator of G Protein Signaling 3 (AGS3) and Peptides Derived from AGS3 with G{alpha}i1.
A. Adhikari and S. R. Sprang (2003)
J. Biol. Chem. 278, 51825-51832
   Abstract »    Full Text »    PDF »
Molecular Basis of Constitutive Production of Basement Membrane Components: GENE EXPRESSION PROFILES OF ENGELBRETH-HOLM-SWARM TUMOR AND F9 EMBRYONAL CARCINOMA CELLS.
S. Futaki, Y. Hayashi, M. Yamashita, K. Yagi, H. Bono, Y. Hayashizaki, Y. Okazaki, and K. Sekiguchi (2003)
J. Biol. Chem. 278, 50691-50701
   Abstract »    Full Text »    PDF »