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Science 12 June 1998:
Vol. 280. no. 5370, pp. 1763 - 1766
DOI: 10.1126/science.280.5370.1763
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Reports

Close Contacts with the Endoplasmic Reticulum as Determinants of Mitochondrial Ca2+ Responses

Rosario Rizzuto, * Paolo Pinton, Walter Carrington, Frederic S. Fay, dagger Kevin E. Fogarty, Lawrence M. Lifshitz, Richard A. Tuft, Tullio Pozzan

The spatial relation between mitochondria and endoplasmic reticulum (ER) in living HeLa cells was analyzed at high resolution in three dimensions with two differently colored, specifically targeted green fluorescent proteins. Numerous close contacts were observed between these organelles, and mitochondria in situ formed a largely interconnected, dynamic network. A Ca2+-sensitive photoprotein targeted to the outer face of the inner mitochondrial membrane showed that, upon opening of the inositol 1,4,5-triphosphate (IP3)-gated channels of the ER, the mitochondrial surface was exposed to a higher concentration of Ca2+ than was the bulk cytosol. These results emphasize the importance of cell architecture and the distribution of organelles in regulation of Ca2+ signaling.

R. Rizzuto, P. Pinton, T. Pozzan, Department of Biomedical Sciences and the National Research Council Center for the Study of Biomembranes, University of Padova, Via Colombo 3, 35121 Padova, Italy.
W. Carrington, F. S. Fay, K. E. Fogarty, L. M. Lifshitz, R. A. Tuft, Biomedical Imaging Group, University of Massachusetts Medical Center, Worcester, MA 01605, USA.
*   To whom correspondence should be addressed. E-mail: rizzuto{at}civ.bio.unipd.it

dagger    Deceased.

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
S. A. Oakes, L. Scorrano, J. T. Opferman, M. C. Bassik, M. Nishino, T. Pozzan, and S. J. Korsmeyer (2005)
PNAS 102, 105-110
   Abstract »    Full Text »    PDF »
Nontranscriptional modulation of intracellular Ca2+ signaling by ligand stimulated thyroid hormone receptor.
N. Saelim, L. M. John, J. Wu, J. S. Park, Y. Bai, P. Camacho, and J. D. Lechleiter (2004)
J. Cell Biol. 167, 915-924
   Abstract »    Full Text »    PDF »
Strong Calcium Entry Activates Mitochondrial Superoxide Generation, Upregulating Kinase Signaling in Hippocampal Neurons.
J. Hongpaisan, C. A. Winters, and S. B. Andrews (2004)
J. Neurosci. 24, 10878-10887
   Abstract »    Full Text »    PDF »
Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit.
M. Yi, D. Weaver, and G. Hajnoczky (2004)
J. Cell Biol. 167, 661-672
   Abstract »    Full Text »    PDF »
The mitochondrial ADPR link between Ca2+ store release and Ca2+ influx channel opening in immune cells.
K. AYUB and M. B. HALLETT (2004)
FASEB J 18, 1335-1338
   Abstract »    Full Text »    PDF »


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