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Science 12 June 1998:
Vol. 280. no. 5370, pp. 1712 - 1713
DOI: 10.1126/science.280.5370.1712
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Research Commentaries

PROTEIN STRUCTURE:
Cytochrome c Oxidase: One Enzyme, Two Mechanisms?

Robert B. Gennis

A research article in this week's issue by Yoshikawa et al. reports the structure of cytochrome c oxidase, an enzyme critical for a large fraction of aerobic respiration. In his commentary, Gennis explains how this structure relates to two previously published structures of the same enzyme and analyzes the controversial proton-pumping mechanism that the authors propose on the basis of their structure.

The author is in the School of Chemical Sciences, University of Illinois, Urbana, IL 61801, USA. E-mail: Gennis{at}aries.scs.uiuc.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Copper and Zinc Inhibit G{alpha}s Function: A NUCLEOTIDE-FREE STATE OF G{alpha}s INDUCED BY Cu2+ AND Zn2+.
X. Gao, Z. Du, and T. B. Patel (2005)
J. Biol. Chem. 280, 2579-2586
   Abstract »    Full Text »    PDF »
Gene Cluster of Rhodothermus marinus High-Potential Iron-Sulfur Protein:Oxygen Oxidoreductase, a caa3-Type Oxidase Belonging to the Superfamily of Heme-Copper Oxidases.
M. Santana, M. M. Pereira, N. P. Elias, C. M. Soares, and M. Teixeira (2001)
J. Bacteriol. 183, 687-699
   Abstract »    Full Text »


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