Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 May 1998:
Vol. 280. no. 5364, pp. 741 - 744
DOI: 10.1126/science.280.5364.741
Prev | Table of Contents | Next

Reports

Yeast Ku as a Regulator of Chromosomal DNA End Structure

Serge Gravel, Michel Larrivée, Pascale Labrecque, Raymund J. Wellinger *

During telomere replication in yeast, chromosome ends acquire an S-phase-specific overhang of the guanosine-rich strand. Here it is shown that in cells lacking Ku, a heterodimeric protein involved in nonhomologous DNA end joining, these overhangs are present throughout the cell cycle. In vivo cross-linking experiments demonstrated that Ku is bound to telomeric DNA. These results show that Ku plays a direct role in establishing a normal DNA end structure on yeast chromosomes, conceivably by functioning as a terminus-binding factor. Because Ku-mediated DNA end joining involving telomeres would result in chromosome instability, our data also suggest that Ku has a distinct function when bound to telomeres.

Département de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, 3001 12th Avenue Nord, Sherbrooke, Quebec QC J1H 5N4, Canada.
*   To whom correspondence should be addressed. E-mail: R.Wellin{at}courrier.usherb.ca

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In Saccharomyces cerevisiae, yKu and Subtelomeric Core X Sequences Repress Homologous Recombination Near Telomeres as Part of the Same Pathway.
M. E. Marvin, C. D. Griffin, D. E. Eyre, D. B. H. Barton, and E. J. Louis (2009)
Genetics 183, 441-451
   Abstract »    Full Text »    PDF »
Telomere Maintenance and Survival in Saccharomyces cerevisiae in the Absence of Telomerase and RAD52.
C. LeBel, E. Rosonina, D. C. F. Sealey, F. Pryde, D. Lydall, L. Maringele, and L. A. Harrington (2009)
Genetics 182, 671-684
   Abstract »    Full Text »    PDF »
Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.
S.-F. Tseng, Z.-J. Shen, H.-J. Tsai, Y.-H. Lin, and S.-C. Teng (2009)
Nucleic Acids Res. 37, 3602-3611
   Abstract »    Full Text »    PDF »
Sequential Loading of Saccharomyces cerevisiae Ku and Cdc13p to Telomeres.
T.-J. Wu, Y.-H. Chiang, Y.-C. Lin, C.-R. Tsai, T.-Y. Yu, M.-T. Sung, Y.-H. W. Lee, and J.-J. Lin (2009)
J. Biol. Chem. 284, 12801-12808
   Abstract »    Full Text »    PDF »
Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.
K. Tomita and J. P. Cooper (2008)
Genes & Dev. 22, 3461-3474
   Abstract »    Full Text »    PDF »
yKu70/yKu80 and Rif1 Regulate Silencing Differentially at Telomeres in Candida glabrata.
L. L. Rosas-Hernandez, A. Juarez-Reyes, O. E. Arroyo-Helguera, A. De Las Penas, S.-J. Pan, B. P. Cormack, and I. Castano (2008)
Eukaryot. Cell 7, 2168-2178
   Abstract »    Full Text »    PDF »
Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1.
J. Franke, J. Gehlen, and A. E. Ehrenhofer-Murray (2008)
J. Cell Sci. 121, 3553-3560
   Abstract »    Full Text »    PDF »
The DNA End-Binding Protein Ku Regulates Silencing at the Internal HML and HMR Loci in Saccharomyces cerevisiae.
C. L. Vandre, R. T. Kamakaka, and D. H. Rivier (2008)
Genetics 180, 1407-1418
   Abstract »    Full Text »    PDF »
The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells.
B. L. Ruis, K. R. Fattah, and E. A. Hendrickson (2008)
Mol. Cell. Biol. 28, 6182-6195
   Abstract »    Full Text »    PDF »
Dynamic Regulation of Single-Stranded Telomeres in Saccharomyces cerevisiae.
S. Smith, S. Banerjee, R. Rilo, and K. Myung (2008)
Genetics 178, 693-701
   Abstract »    Full Text »    PDF »
DNA damage response at functional and dysfunctional telomeres.
M. P. Longhese (2008)
Genes & Dev. 22, 125-140
   Abstract »    Full Text »    PDF »
The Role of Stn1p in Saccharomyces cerevisiae Telomere Capping Can Be Separated From Its Interaction With Cdc13p.
R. C. Petreaca, H.-C. Chiu, and C. I. Nugent (2007)
Genetics 177, 1459-1474
   Abstract »    Full Text »    PDF »
MRX-dependent DNA Damage Response to Short Telomeres.
V. Viscardi, D. Bonetti, H. Cartagena-Lirola, G. Lucchini, and M. P. Longhese (2007)
Mol. Biol. Cell 18, 3047-3058
   Abstract »    Full Text »    PDF »
Telomerase core components protect Candida telomeres from aberrant overhang accumulation.
M. Hsu, M. J. McEachern, A. T. Dandjinou, Y. Tzfati, E. Orr, E. H. Blackburn, and N. F. Lue (2007)
PNAS 104, 11682-11687
   Abstract »    Full Text »    PDF »
The Role Of Nonhomologous End-Joining Components in Telomere Metabolism in Kluyveromyces lactis.
S. D. Carter, S. Iyer, J. Xu, M. J. McEachern, and S. U. Astrom (2007)
Genetics 175, 1035-1045
   Abstract »    Full Text »    PDF »
Modulation of telomere terminal structure by telomerase components in Candida albicans..
O. Steinberg-Neifach and N. F. Lue (2006)
Nucleic Acids Res. 34, 2710-2722
   Abstract »    Full Text »    PDF »
Inactivation of Ku-Mediated End Joining Suppresses mec1{Delta} Lethality by Depleting the Ribonucleotide Reductase Inhibitor Sml1 through a Pathway Controlled by Tel1 Kinase and the Mre11 Complex.
Y. Corda, S. E. Lee, S. Guillot, A. Walther, J. Sollier, A. Arbel-Eden, J. E. Haber, and V. Geli (2005)
Mol. Cell. Biol. 25, 10652-10664
   Abstract »    Full Text »    PDF »
Regulation of Telomere Length by an N-Terminal Region of the Yeast Telomerase Reverse Transcriptase.
H. Ji, M. H. Platts, L. M. Dharamsi, and K. L. Friedman (2005)
Mol. Cell. Biol. 25, 9103-9114
   Abstract »    Full Text »    PDF »
The Arabidopsis Pot1 and Pot2 Proteins Function in Telomere Length Homeostasis and Chromosome End Protection.
E. V. Shakirov, Y. V. Surovtseva, N. Osbun, and D. E. Shippen (2005)
Mol. Cell. Biol. 25, 7725-7733
   Abstract »    Full Text »    PDF »
Def1p Is Involved in Telomere Maintenance in Budding Yeast.
Y.-B. Chen, C.-P. Yang, R.-X. Li, R. Zeng, and J.-Q. Zhou (2005)
J. Biol. Chem. 280, 24784-24791
   Abstract »    Full Text »    PDF »
The Ku Protein Complex Is Involved in Length Regulation of Drosophila Telomeres.
L. Melnikova, H. Biessmann, and P. Georgiev (2005)
Genetics 170, 221-235
   Abstract »    Full Text »    PDF »
Telomere length regulation and transcriptional silencing in KU80-deficient Trypanosoma brucei.
C. J. Janzen, F. Lander, O. Dreesen, and G. A. M. Cross (2004)
Nucleic Acids Res. 32, 6575-6584
   Abstract »    Full Text »    PDF »
Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules.
L. Xu and E. H. Blackburn (2004)
J. Cell Biol. 167, 819-830
   Abstract »    Full Text »    PDF »
Phosphorylation of H2AX at Short Telomeres in T Cells and Fibroblasts.
L.-Y. Hao, M. A. Strong, and C. W. Greider (2004)
J. Biol. Chem. 279, 45148-45154
   Abstract »    Full Text »    PDF »
Role of Human Ku86 in Telomere Length Maintenance and Telomere Capping.
I. Jaco, P. Munoz, and M. A. Blasco (2004)
Cancer Res. 64, 7271-7278
   Abstract »    Full Text »    PDF »
Functional links between telomeres and proteins of the DNA-damage response.
F. d'Adda di Fagagna, S.-H. Teo, and S. P. Jackson (2004)
Genes & Dev. 18, 1781-1799
   Abstract »    Full Text »    PDF »
Stm1p, a G4 Quadruplex and Purine Motif Triplex Nucleic Acid-binding Protein, Interacts with Ribosomes and Subtelomeric Y' DNA in Saccharomyces cerevisiae.
M. W. Van Dyke, L. D. Nelson, R. G. Weilbaecher, and D. V. Mehta (2004)
J. Biol. Chem. 279, 24323-24333
   Abstract »    Full Text »    PDF »
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86.
K. Myung, G. Ghosh, F. J. Fattah, G. Li, H. Kim, A. Dutia, E. Pak, S. Smith, and E. A. Hendrickson (2004)
Mol. Cell. Biol. 24, 5050-5059
   Abstract »    Full Text »    PDF »
Plant Telomere Biology.
T. D. McKnight and D. E. Shippen (2004)
PLANT CELL 16, 794-803
   Full Text »    PDF »
EXO1 Contributes to Telomere Maintenance in Both Telomerase-Proficient and Telomerase-Deficient Saccharomyces cerevisiae.
A. A. Bertuch and V. Lundblad (2004)
Genetics 166, 1651-1659
   Abstract »    Full Text »    PDF »
Introduction of Human Telomerase Reverse Transcriptase to Normal Human Fibroblasts Enhances DNA Repair Capacity.
K.-H. Shin, M. K. Kang, E. Dicterow, A. Kameta, M. A. Baluda, and N.-H. Park (2004)
Clin. Cancer Res. 10, 2551-2560
   Abstract »    Full Text »    PDF »
Mutant Telomere Sequences Lead to Impaired Chromosome Separation and a Unique Checkpoint Response.
J. Lin, D. L. Smith, and E. H. Blackburn (2004)
Mol. Biol. Cell 15, 1623-1634
   Abstract »    Full Text »    PDF »
Interaction of an Arabidopsis RNA-binding Protein with Plant Single-stranded Telomeric DNA Modulates Telomerase Activity.
C. Kwon and I. K. Chung (2004)
J. Biol. Chem. 279, 12812-12818
   Abstract »    Full Text »    PDF »
Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase.
K. P. Sundararaj, R. E. Wood, S. Ponnusamy, A. M. Salas, Z. Szulc, A. Bielawska, L. M. Obeid, Y. A. Hannun, and B. Ogretmen (2004)
J. Biol. Chem. 279, 6152-6162
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae Sin3p facilitates DNA double-strand break repair.
A. Jazayeri, A. D. McAinsh, and S. P. Jackson (2004)
PNAS 101, 1644-1649
   Abstract »    Full Text »    PDF »
REP3-Mediated Silencing in Saccharomyces cerevisiae.
L. A. Papacs, Y. Sun, E. L. Anderson, J. Sun, and S. G. Holmes (2004)
Genetics 166, 79-87
   Abstract »    Full Text »    PDF »
The Drosophila melanogaster DNA Ligase IV Gene Plays a Crucial Role in the Repair of Radiation-Induced DNA Double-Strand Breaks and Acts Synergistically With Rad54.
M. M. Gorski, J. C. J. Eeken, A. W. M. de Jong, I. Klink, M. Loos, R. J. Romeijn, B. L. van Veen, L. H. Mullenders, W. Ferro, and A. Pastink (2003)
Genetics 165, 1929-1941
   Abstract »    Full Text »    PDF »
The Ku Heterodimer Performs Separable Activities at Double-Strand Breaks and Chromosome Termini.
A. A. Bertuch and V. Lundblad (2003)
Mol. Cell. Biol. 23, 8202-8215
   Abstract »    Full Text »    PDF »
Hiding at the ends of yeast chromosomes: telomeres, nucleases and checkpoint pathways.
D. Lydall (2003)
J. Cell Sci. 116, 4057-4065
   Abstract »    Full Text »    PDF »
Which end: dissecting Ku's function at telomeres and double-strand breaks.
A. A. Bertuch and V. Lundblad (2003)
Genes & Dev. 17, 2347-2350
   Full Text »    PDF »
Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.
A. E. Stellwagen, Z. W. Haimberger, J. R. Veatch, and D. E. Gottschling (2003)
Genes & Dev. 17, 2384-2395
   Abstract »    Full Text »    PDF »
Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae.
P. A. Mieczkowski, J. O. Mieczkowska, M. Dominska, and T. D. Petes (2003)
PNAS 100, 10854-10859
   Abstract »    Full Text »    PDF »
Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.
T. Kibe, K. Tomita, A. Matsuura, D. Izawa, T. Kodaira, T. Ushimaru, M. Uritani, and M. Ueno (2003)
Nucleic Acids Res. 31, 5054-5063
   Abstract »    Full Text »    PDF »
Sudden Telomere Lengthening Triggers a Rad53-dependent Checkpoint in Saccharomyces cerevisiae.
V. Viscardi, E. Baroni, M. Romano, G. Lucchini, and M. P. Longhese (2003)
Mol. Biol. Cell 14, 3126-3143
   Abstract »    Full Text »    PDF »
The Rad51 Pathway of Telomerase-Independent Maintenance of Telomeres Can Amplify TG1-3 Sequences in yku and cdc13 Mutants of Saccharomyces cerevisiae.
N. Grandin and M. Charbonneau (2003)
Mol. Cell. Biol. 23, 3721-3734
   Abstract »    Full Text »    PDF »
Telomerase Dependence of Telomere Lengthening in ku80 Mutant Arabidopsis.
M. E. Gallego, N. Jalut, and C. I. White (2003)
PLANT CELL 15, 782-789
   Abstract »    Full Text »    PDF »
Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis.
K. Riha and D. E. Shippen (2003)
PNAS 100, 611-615
   Abstract »    Full Text »    PDF »
Telomeric DNA Ends Are Essential for the Localization of Ku at Telomeres in Fission Yeast.
T. Miyoshi, M. Sadaie, J. Kanoh, and F. Ishikawa (2003)
J. Biol. Chem. 278, 1924-1931
   Abstract »    Full Text »    PDF »
Differential Processing of Leading- and Lagging-Strand Ends at Saccharomyces cerevisiae Telomeres Revealed by the Absence of Rad27p Nuclease.
J. Parenteau and R. J. Wellinger (2002)
Genetics 162, 1583-1594
   Abstract »    Full Text »    PDF »
Human Ku70/80 Associates Physically with Telomerase through Interaction with hTERT.
W. Chai, L. P. Ford, L. Lenertz, W. E. Wright, and J. W. Shay (2002)
J. Biol. Chem. 277, 47242-47247
   Abstract »    Full Text »    PDF »
Ku complex controls the replication time of DNA in telomere regions.
A. J. Cosgrove, C. A. Nieduszynski, and A. D. Donaldson (2002)
Genes & Dev. 16, 2485-2490
   Abstract »    Full Text »    PDF »
Involvement of Replicative Polymerases, Tel1p, Mec1p, Cdc13p, and the Ku Complex in Telomere-Telomere Recombination.
Y.-L. Tsai, S.-F. Tseng, S.-H. Chang, C.-C. Lin, and S.-C. Teng (2002)
Mol. Cell. Biol. 22, 5679-5687
   Abstract »    Full Text »    PDF »
EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants.
L. Maringele and D. Lydall (2002)
Genes & Dev. 16, 1919-1933
   Abstract »    Full Text »    PDF »
Telomere Binding of Checkpoint Sensor and DNA Repair Proteins Contributes to Maintenance of Functional Fission Yeast Telomeres.
T. M. Nakamura, B. A. Moser, and P. Russell (2002)
Genetics 161, 1437-1452
   Abstract »    Full Text »    PDF »
Effects of double-strand break repair proteins on vertebrate telomere structure.
C. Wei, R. Skopp, M. Takata, S. Takeda, and C. M. Price (2002)
Nucleic Acids Res. 30, 2862-2870
   Abstract »    Full Text »    PDF »
A Quantitative Assay for Telomere Protection in Saccharomyces cerevisiae.
M. L. DuBois, Z. W. Haimberger, M. W. McIntosh, and D. E. Gottschling (2002)
Genetics 161, 995-1013
   Abstract »    Full Text »    PDF »
Saccharomyces Rrm3p, a 5' to 3' DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA.
A. S. Ivessa, J.-Q. Zhou, V. P. Schulz, E. K. Monson, and V. A. Zakian (2002)
Genes & Dev. 16, 1383-1396
   Abstract »    Full Text »    PDF »
Maintenance of Double-Stranded Telomeric Repeats as the Critical Determinant for Cell Viability in Yeast Cells Lacking Ku.
S. Gravel and R. J. Wellinger (2002)
Mol. Cell. Biol. 22, 2182-2193
   Abstract »    Full Text »    PDF »
Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Y. Huang (2002)
Nucleic Acids Res. 30, 1465-1482
   Abstract »    Full Text »    PDF »
p53 Binds Telomeric Single Strand Overhangs and t-Loop Junctions in Vitro.
R. M. Stansel, D. Subramanian, and J. D. Griffith (2002)
J. Biol. Chem. 277, 11625-11628
   Abstract »    Full Text »    PDF »
DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei.
P. Grandi, M. Eltsov, I. Nielsen, and I. Raska (2002)
J. Cell Sci. 114, 3345-3357
   Abstract »    Full Text »    PDF »
Natural and pharmacological regulation of telomerase.
J.-L. Mergny, J.-F. Riou, P. Mailliet, M.-P. Teulade-Fichou, and E. Gilson (2002)
Nucleic Acids Res. 30, 839-865
   Abstract »    Full Text »    PDF »
Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.
J. Huang and W. S. Dynan (2002)
Nucleic Acids Res. 30, 667-674
   Abstract »    Full Text »    PDF »
Involvement of Cellular Double-Stranded DNA Break Binding Proteins in Processing of the Recombinant Adeno-Associated Virus Genome.
L. Zentilin, A. Marcello, and M. Giacca (2001)
J. Virol. 75, 12279-12287
   Abstract »    Full Text »    PDF »
NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway.
M. Frank-Vaillant and S. Marcand (2001)
Genes & Dev. 15, 3005-3012
   Abstract »    Full Text »    PDF »
Quantitative amplification of single-stranded DNA (QAOS) demonstrates that cdc13-1 mutants generate ssDNA in a telomere to centromere direction.
C. Booth, E. Griffith, G. Brady, and D. Lydall (2001)
Nucleic Acids Res. 29, 4414-4422
   Abstract »    Full Text »    PDF »
Intrachromatid Excision of Telomeric DNA as a Mechanism for Telomere Size Control in Saccharomyces cerevisiae.
M. Bucholc, Y. Park, and A. J. Lustig (2001)
Mol. Cell. Biol. 21, 6559-6573
   Abstract »    Full Text »    PDF »
New Function of CDC13 in Positive Telomere Length Regulation.
B. Meier, L. Driller, S. Jaklin, and H. M. Feldmann (2001)
Mol. Cell. Biol. 21, 4233-4245
   Abstract »    Full Text »    PDF »
The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang.
F. A. Goytisolo, E. Samper, S. Edmonson, G. E. Taccioli, and M. A. Blasco (2001)
Mol. Cell. Biol. 21, 3642-3651
   Abstract »    Full Text »
Yeast telomerase appears to frequently copy the entire template in vivo.
A. Ray and K. W. Runge (2001)
Nucleic Acids Res. 29, 2382-2394
   Abstract »    Full Text »    PDF »
Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro.
E. M. Lynch, R. B. Moreland, I. Ginis, S. P. Perrine, and D. V. Faller (2001)
Am J Physiol Cell Physiol 280, C897-C911
   Abstract »    Full Text »    PDF »
Cdc13 both positively and negatively regulates telomere replication.
A. Chandra, T. R. Hughes, C. I. Nugent, and V. Lundblad (2001)
Genes & Dev. 15, 404-414
   Abstract »    Full Text »
Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits.
J Bertinato, C Schild-Poulter, and R. Hache (2001)
J. Cell Sci. 114, 89-99
   Abstract »    PDF »
Cdc13 Cooperates with the Yeast Ku Proteins and Stn1 To Regulate Telomerase Recruitment.
N. Grandin, C. Damon, and M. Charbonneau (2000)
Mol. Cell. Biol. 20, 8397-8408
   Abstract »    Full Text »
An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria.
G. Coffey and C. Campbell (2000)
Nucleic Acids Res. 28, 3793-3800
   Abstract »    Full Text »    PDF »
Protection of Telomeres by the Ku Protein in Fission Yeast.
P. Baumann and T. R. Cech (2000)
Mol. Biol. Cell 11, 3265-3275
   Abstract »    Full Text »
Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres.
K. Forstemann, M. Hoss, and J. Lingner (2000)
Nucleic Acids Res. 28, 2690-2694
   Abstract »    Full Text »    PDF »
The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein.
H. Qi and V. A. Zakian (2000)
Genes & Dev. 14, 1777-1788
   Abstract »    Full Text »
A Sense of the End.
S. M. Gasser (2000)
Science 288, 1377-1379
   Abstract »    Full Text »
Cancer Risk and the ATM Gene: a Continuing Debate.
K. K. Khanna (2000)
J Natl Cancer Inst 92, 795-802
   Abstract »    Full Text »    PDF »
Telomerase RNA Template Mutations Reveal Sequence-Specific Requirements for the Activation and Repression of Telomerase Action at Telomeres.
J. C. Prescott and E. H. Blackburn (2000)
Mol. Cell. Biol. 20, 2941-2948
   Abstract »    Full Text »
Subtelomeric Repeat Amplification Is Associated With Growth at Elevated Temperature in yku70 Mutants of Saccharomyces cerevisiae.
B. Fellerhoff, F. Eckardt-Schupp, and A. A. Friedl (2000)
Genetics 154, 1039-1051
   Abstract »    Full Text »
The Function of DNA Polymerase alpha at Telomeric G Tails Is Important for Telomere Homeostasis.
A. A. Martin, I. Dionne, R. J. Wellinger, and C. Holm (2000)
Mol. Cell. Biol. 20, 786-796
   Abstract »    Full Text »
Positive and negative regulation of telomerase access to the telomere.
S. Evans and V Lundblad (2000)
J. Cell Sci. 113, 3357-3364
   Abstract »    PDF »
Molecular Manifestations and Molecular Determinants of Telomere Capping.
E.H. BLACKBURN, S. CHAN, J. CHANG, T.B. FULTON, A. KRAUSKOPF, M. MCEACHERN, J. PRESCOTT, J. ROY, C. SMITH, and H. WANG (2000)
Cold Spring Harb Symp Quant Biol 65, 253-264
   Abstract »    PDF »
Telomere Length, Telomere-binding Proteins, and DNA Damage Signaling.
M.T. HEMANN, J. HACKETT, A. IJPMA, and C.W. GREIDER (2000)
Cold Spring Harb Symp Quant Biol 65, 275-280
   Abstract »    PDF »
All Things Must End: Telomere Dynamics in Yeast.
M.L. DUBOIS, S.J. DIEDE, A.E. STELLWAGEN, and D.E. GOTTSCHLING (2000)
Cold Spring Harb Symp Quant Biol 65, 281-296
   Abstract »    PDF »
Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells.
A. Ray and K. W. Runge (1999)
PNAS 96, 15044-15049
   Abstract »    Full Text »    PDF »
Telomere-Telomere Recombination Is an Efficient Bypass Pathway for Telomere Maintenance in Saccharomyces cerevisiae.
S.-C. Teng and V. A. Zakian (1999)
Mol. Cell. Biol. 19, 8083-8093
   Abstract »    Full Text »    PDF »
Irradiation-Induced Rescue of Thymocyte Differentiation and V(D)J Recombination in Mice Lacking the Catalytic Subunit of DNA-Dependent Protein Kinase.
C. Wang, M. A. Bogue, A. P. Nguyen, and D. B. Roth (1999)
J. Immunol. 163, 6065-6071
   Abstract »    Full Text »    PDF »
Ku is associated with the telomere in mammals.
H.-L. Hsu, D. Gilley, E. H. Blackburn, and D. J. Chen (1999)
PNAS 96, 12454-12458
   Abstract »    Full Text »    PDF »
DOT4 Links Silencing and Cell Growth in Saccharomyces cerevisiae.
A. Kahana and D. E. Gottschling (1999)
Mol. Cell. Biol. 19, 6608-6620
   Abstract »    Full Text »    PDF »
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.
M. Kaeberlein, M. McVey, and L. Guarente (1999)
Genes & Dev. 13, 2570-2580
   Abstract »    Full Text »
Ku Binds Telomeric DNA in Vitro.
A. Bianchi and T. de Lange (1999)
J. Biol. Chem. 274, 21223-21227
   Abstract »    Full Text »    PDF »
Poly(ADP-ribose) Polymerase and Ku Autoantigen Form a Complex and Synergistically Bind to Matrix Attachment Sequences.
S. Galande and T. Kohwi-Shigematsu (1999)
J. Biol. Chem. 274, 20521-20528
   Abstract »    Full Text »    PDF »
Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription.
W. Giffin, W. Gong, C. Schild-Poulter, and R. J. G. Hache (1999)
Mol. Cell. Biol. 19, 4065-4078
   Abstract »    Full Text »    PDF »
RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase.
S. Le, J. K. Moore, J. E. Haber, and C. W. Greider (1999)
Genetics 152, 143-152
   Abstract »    Full Text »
The DNA-dependent protein kinase.
G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
   Full Text »
Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts.
P. Labhart (1999)
Mol. Cell. Biol. 19, 2585-2593
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)