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Science 1 May 1998:
Vol. 280. no. 5364, pp. 741 - 744
DOI: 10.1126/science.280.5364.741
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Reports

Yeast Ku as a Regulator of Chromosomal DNA End Structure

Serge Gravel, Michel Larrivée, Pascale Labrecque, Raymund J. Wellinger *

During telomere replication in yeast, chromosome ends acquire an S-phase-specific overhang of the guanosine-rich strand. Here it is shown that in cells lacking Ku, a heterodimeric protein involved in nonhomologous DNA end joining, these overhangs are present throughout the cell cycle. In vivo cross-linking experiments demonstrated that Ku is bound to telomeric DNA. These results show that Ku plays a direct role in establishing a normal DNA end structure on yeast chromosomes, conceivably by functioning as a terminus-binding factor. Because Ku-mediated DNA end joining involving telomeres would result in chromosome instability, our data also suggest that Ku has a distinct function when bound to telomeres.

Département de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke, 3001 12th Avenue Nord, Sherbrooke, Quebec QC J1H 5N4, Canada.
*   To whom correspondence should be addressed. E-mail: R.Wellin{at}courrier.usherb.ca

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   Abstract »    Full Text »    PDF »
RAD50 and RAD51 Define Two Pathways That Collaborate to Maintain Telomeres in the Absence of Telomerase.
S. Le, J. K. Moore, J. E. Haber, and C. W. Greider (1999)
Genetics 152, 143-152
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Science. ISSN 0036-8075 (print), 1095-9203 (online)