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Science 10 April 1998:
Vol. 280. no. 5361, p. 227
DOI: 10.1126/science.280.5361.227
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Research Commentaries

IMMUNOLOGY:
Update: The Numbers Game for Virus-Specific CD8+ T Cells

Peter C. Doherty

Recent advances have, for the first time, allowed accurate quantitation of the virus-specific effector and memory CD8+ T lymphocyte responses. The T cell numbers are much higher than anyone had previously suspected. The consequence is a revolution in our understanding of cell-mediated immunity in virus infections.

The author is in the Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. E-mail: peter.doherty{at}stjude.org

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