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Science 6 March 1998:
Vol. 279. no. 5356, pp. 1528 - 1530
DOI: 10.1126/science.279.5356.1528
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Reports

Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello Coletta, Egle Paolucci, Anna Stornaiuolo, Giulio Cossu, * Fulvio Mavilio *

Growth and repair of skeletal muscle are normally mediated by the satellite cells that surround muscle fibers. In regenerating muscle, however, the number of myogenic precursors exceeds that of resident satellite cells, implying migration or recruitment of undifferentiated progenitors from other sources. Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Genetically modified, marrow-derived myogenic progenitors could potentially be used to target therapeutic genes to muscle tissue, providing an alternative strategy for treatment of muscular dystrophies.

G. Ferrari, E. Paolucci, A. Stornaiuolo, F. Mavilio, H. San Raffaele-Telethon Institute for Gene Therapy (TIGET), 20132 Milan, Italy.
G. Cusella-De Angelis, Istituto di Anatomia Umana Normale, University of Pavia, 27100 Pavia, Italy.
M. Coletta and G. Cossu, Istituto Pasteur-Fondazione Cenci-Bolognetti,Dipartimento di Istologia ed Embriologia Medica, University of Rome "La Sapienza", 00161 Rome, Italy.
*   To whom correspondence should be addressed. E-mail: cossu{at}axrma.uniroma1.it (G.C.) or mavilio{at}tigem.it (F.M.).

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J. Cell Biol. 172, 103-113
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A Side Order of Stem Cells: The SP Phenotype..
G. A. Challen and M. H. Little (2006)
Stem Cells 24, 3-12
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Bone Marrow Lacks a Transplantable Progenitor for Smooth Muscle Type {alpha}-Actin-Expressing Cells.
T. Yokota, Y. Kawakami, Y. Nagai, J.-x. Ma, J.-Y. Tsai, P. W. Kincade, and S. Sato (2006)
Stem Cells 24, 13-22
   Abstract »    Full Text »    PDF »
The Muscular Dystrophies: From Genes to Therapies.
R. M Lovering, N. C Porter, and R. J Bloch (2005)
Physical Therapy 85, 1372-1388
   Abstract »    Full Text »    PDF »
Cell-Based Cardiac Repair: Reflections at the 10-Year Point.
C. E. Murry, L. J. Field, and P. Menasche (2005)
Circulation 112, 3174-3183
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Donor origin of multipotent adult progenitor cells in radiation chimeras.
M. Reyes, S. Li, J. Foraker, E. Kimura, and J. S. Chamberlain (2005)
Blood 106, 3646-3649
   Abstract »    Full Text »    PDF »
IGF-I increases bone marrow contribution to adult skeletal muscle and enhances the fusion of myelomonocytic precursors.
A. Sacco, R. Doyonnas, M. A. LaBarge, M. M. Hammer, P. Kraft, and H. M. Blau (2005)
J. Cell Biol. 171, 483-492
   Abstract »    Full Text »    PDF »
Fusion of bone marrow-derived stem cells with cardiomyocytes in a heterologous in vitro model.
J. Garbade, A. Schubert, A. J. Rastan, D. Lenz, T. Walther, J. F. Gummert, S. Dhein, and F.-W. Mohr (2005)
Eur. J. Cardiothorac. Surg. 28, 685-691
   Abstract »    Full Text »    PDF »
Activation of Myogenic Differentiation Pathways in Adult Bone Marrow-Derived Stem Cells.
F. Belema Bedada, A. Technau, H. Ebelt, M. Schulze, and T. Braun (2005)
Mol. Cell. Biol. 25, 9509-9519
   Abstract »    Full Text »    PDF »
Establishment and characterization of renal progenitor like cells from S3 segment of nephron in rat adult kidney.
S. Kitamura, Y. Yamasaki, M. Kinomura, T. Sugaya, H. Sugiyama, Y. Maeshima, and H. Makino (2005)
FASEB J 19, 1789-1797
   Abstract »    Full Text »    PDF »
Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6.
C. Decraene, R. Benchaouir, M.-A. Dillies, D. Israeli, S. Bortoli, C. Rochon, P. Rameau, A. Pitaval, D. T.-L. Roux, O. Danos, et al. (2005)
Physiol Genomics 23, 132-149
   Abstract »    Full Text »    PDF »
Persistence of marrow stromal cells implanted into acutely infarcted myocardium: Observations in a xenotransplant model.
D. J. MacDonald, J. Luo, T. Saito, M. Duong, P.-L. Bernier, R. C.J. Chiu, and D. Shum-Tim (2005)
J. Thorac. Cardiovasc. Surg. 130, 1114-1121
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A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.
M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia (2005)
J. Cell Sci. 118, 4343-4352
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Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle.
C. M. Westerkamp and S. E. Gordon (2005)
Am J Physiol Regulatory Integrative Comp Physiol 289, R1223-R1231
   Abstract »    Full Text »    PDF »
Stem Cell Research: Paths to Cancer Therapies and Regenerative Medicine.
I. Weissman (2005)
JAMA 294, 1359-1366
   Abstract »    Full Text »    PDF »
Optimizing Techniques for Tracking Transplanted Stem Cells In Vivo.
T. R. Brazelton and H. M. Blau (2005)
Stem Cells 23, 1251-1265
   Abstract »    Full Text »    PDF »
Cell Transplantation Improves Ventricular Function After a Myocardial Infarction: A Preclinical Study of Human Unrestricted Somatic Stem Cells in a Porcine Model.
B.-O. Kim, H. Tian, K. Prasongsukarn, J. Wu, D. Angoulvant, S. Wnendt, A. Muhs, D. Spitkovsky, and R.-K. Li (2005)
Circulation 112, I-96-I-104
   Abstract »    Full Text »    PDF »


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