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Science 27 February 1998:
Vol. 279. no. 5355, pp. 1355 - 1358
DOI: 10.1126/science.279.5355.1355
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Reports

Linkage of Adhesion, Filamentous Growth, and Virulence in Candida albicans to a Single Gene, INT1

Cheryl A. Gale, Catherine M. Bendel, Mark McClellan, Melinda Hauser, Jeffrey M. Becker, Judith Berman, * Margaret K. Hostetter *

Adhesion and the ability to form filaments are thought to contribute to the pathogenicity of Candida albicans, the leading cause of fungal disease in immunocompromised patients. Int1p is a C. albicans surface protein with limited similarity to vertebrate integrins. INT1 expression in Saccharomyces cerevisiae was sufficient to direct the adhesion of this normally nonadherent yeast to human epithelial cells. Furthermore, disruption of INT1 in C. albicans suppressed hyphal growth, adhesion to epithelial cells, and virulence in mice. Thus, INT1 links adhesion, filamentous growth, and pathogenicity in C. albicans and Int1p may be an attractive target for the development of antifungal therapies.

C. A. Gale, Department of Pediatrics, University of Minnesota, 420 Delaware Street S.E., Minneapolis, MN 55455, USA, and Department of Plant Biology, University of Minnesota, 220 Biological Sciences Center, St. Paul, MN 55108, USA.
C. M. Bendel, M. McClellan, M. K. Hostetter, Department of Pediatrics, University of Minnesota, 420 Delaware Street S.E., Minneapolis, MN 55455, USA.
M. Hauser and J. M. Becker, Department of Microbiology, University of Tennessee, M409 Walters Life Sciences, Knoxville, TN 37996, USA.
J. Berman, Department of Plant Biology, University of Minnesota, 220 Biological Sciences Center, St. Paul, MN 55108, USA.
*   To whom correspondence should be addressed. E-mail: judith{at}biosci.cbs.umn.edu and hoste001{at}maroon.tc.umn.edu

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