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Science 20 February 1998:
Vol. 279. no. 5354, pp. 1133 - 1134
DOI: 10.1126/science.279.5354.1133
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Research News

AIDS THERAPY:
Failure Isn't What It Used to Be ... But Neither Is Success

Jon Cohen

CHICAGO--Until now, researchers have assumed that if virus levels go up in patients on the new AIDS treatments that are helping HIV-infected people live longer, healthier lives, the treatment has failed. But new data presented here at the Fifth Conference on Retroviruses and Opportunistic Infections indicate that immune-cell levels can remain high even when the virus is thriving--perhaps because other factors besides viral levels can affect immune-cell production, powerful new tests suggest. But 12 groups also reported a down side to this good news: Long-term treatment with protease inhibitors causes a puzzling redistribution of body fat that could be an omen of other, more serious side effects.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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HIV protease inhibitors restore impaired T-cell proliferative response in vivo and in vitro: a viral-suppression-independent mechanism.
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Blood 96, 250-258
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Human Immunodeficiency Virus Type 1 Protease Inhibitor Modulates Activation of Peripheral Blood CD4+ T Cells and Decreases Their Susceptibility to Apoptosis In Vitro and In Vivo.
E. M. Sloand, P. N. Kumar, S. Kim, A. Chaudhuri, F. F. Weichold, and N. S. Young (1999)
Blood 94, 1021-1027
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HIV Treatment Failure: Testing for HIV Resistance in Clinical Practice.
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Science 280, 1871-1873
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