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Science 20 February 1998:
Vol. 279. no. 5354, pp. 1129 - 1131
DOI: 10.1126/science.279.5354.1129
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Research News

CELL BIOLOGY:
The Nucleus's Revolving Door

Elizabeth Pennisi

Work done over the past 2 years shows that cells have evolved a highly complex system, involving an intricate division of labor among a host of different proteins that are structurally related, for transporting large molecules such as proteins and mRNAs into and out of the nucleus. Recent work also indicates that a small protein called Ran acts as the dispatcher, coordinating the direction of transport and linking the various nuclear transport pathways with critical events in the life and death of the cell. Because critical processes such as cell division and protein synthesis depend on molecules that have to be carried into or out of the nucleus at exactly the right time, these new findings are causing more and more researchers to take notice of the pivotal role nuclear transport plays in the life of the cell.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cell Density Regulates Intracellular Localization of Aryl Hydrocarbon Receptor.
T. Ikuta, Y. Kobayashi, and K. Kawajiri (2004)
J. Biol. Chem. 279, 19209-19216
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The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver.
I. Zelko, T. Sueyoshi, T. Kawamoto, R. Moore, and M. Negishi (2001)
Mol. Cell. Biol. 21, 2838-2846
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Small GTP-Binding Proteins.
Y. Takai, T. Sasaki, and T. Matozaki (2001)
Physiol Rev 81, 153-208
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The importin/karyopherin Kap114 mediates the nuclear import of TATA-binding protein.
H. Morehouse, R. M. Buratowski, P. A. Silver, and S. Buratowski (1999)
PNAS 96, 12542-12547
   Abstract »    Full Text »    PDF »
Developmental Genetics of the Essential Drosophila Nucleoporin nup154: Allelic Differences Due to an Outward-Directed Promoter in the P-Element 3' End.
A. A. Kiger, S. Gigliotti, and M. T. Fuller (1999)
Genetics 153, 799-812
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A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA.
J. Ludtke, G Zhang, M. Sebestyen, and J. Wolff (1999)
J. Cell Sci. 112, 2033-2041
   Abstract »    PDF »
Ran and Nuclear Transport.
M. S. Moore (1998)
J. Biol. Chem. 273, 22857-22860
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Directed Inhibition of Nuclear Import in Cellular Hypertrophy.
C. Perez-Terzic, A. M. Gacy, R. Bortolon, P. P. Dzeja, M. Puceat, M. Jaconi, F. G. Prendergast, and A. Terzic (2001)
J. Biol. Chem. 276, 20566-20571
   Abstract »    Full Text »    PDF »


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