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Science 6 February 1998:
Vol. 279. no. 5352, pp. 863 - 867
DOI: 10.1126/science.279.5352.863
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Reports

Impaired Locomotion and Dopamine Signaling in Retinoid Receptor Mutant Mice

Wojciech Kr&ecedil;żel, Norbert Ghyselinck, * Tarek A. Samad, * Valérie Dupé, Philippe Kastner, Emiliana Borrelli, Pierre Chambon dagger

In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor beta  and retinoid X receptors beta  and gamma  resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université Louis Pasteur, Collège de France, Boite Postale 163, 67404 Illkirch Cedex, France.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: igbmc{at}igbmc.u-strasbg.fr

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