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Science 16 January 1998:
Vol. 279. no. 5349, pp. 381 - 384
DOI: 10.1126/science.279.5349.381
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Reports

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

James J. Campbell, Joseph Hedrick, Albert Zlotnik, Michael A. Siani, Darren A. Thompson, Eugene C. Butcher

Circulating lymphocytes are recruited from the blood to the tissue by rolling along the endothelium until being stopped by a signaling event linked to the Gialpha subunit of a heterotrimeric GTP-binding protein; that event then triggers rapid integrin-dependent adhesion. Four chemokines are now shown to induce such adhesion to intercellular adhesion molecule-1 and to induce arrest of rolling cells within 1 second under flow conditions similar to those of blood. SDF-1 (also called PBSF), 6-C-kine (also called Exodus-2), and MIP-3beta (also called ELC or Exodus-3) induced adhesion of most circulating lymphocytes, including most CD4+ T cells; and MIP-3alpha (also called LARC or Exodus-1) triggered adhesion of memory, but not naïve, CD4+ T cells. Thus, chemokines can regulate the arrest of lymphocyte subsets under flowing conditions, which may allow them to control lymphocyte-endothelial cell recognition and lymphocyte recruitment in vivo.

J. J. Campbell and E. C. Butcher, Laboratory of Immunology and Vascular Biology, Department of Pathology, and Digestive Disease Center, Department of Medicine, Stanford University Medical School, Stanford, CA 94305, USA, and Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
J. Hedrick and A. Zlotnik, Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA.
M. A. Siani and D. A. Thompson, Gryphon Sciences, South San Francisco, CA 94080, USA.

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In Vivo Impairment of Neutrophil Recruitment during Lentivirus Infection.
P. Kubes, B. Heit, G. van Marle, J. B. Johnston, D. Knight, A. Khan, and C. Power (2003)
J. Immunol. 171, 4801-4808
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CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress.
A. Meissner, O. Zilles, R. Varona, K. Jozefowski, U. Ritter, G. Marquez, R. Hallmann, and H. Korner (2003)
Blood 102, 2724-2727
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{alpha}4{beta}1 Integrin Affinity Changes Govern Cell Adhesion.
A. Chigaev, G. Zwartz, S. W. Graves, D. C. Dwyer, H. Tsuji, T. D. Foutz, B. S. Edwards, E. R. Prossnitz, R. S. Larson, and L. A. Sklar (2003)
J. Biol. Chem. 278, 38174-38182
   Abstract »    Full Text »    PDF »
The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.
A J Stagg, A L Hart, S C Knight, and M A Kamm (2003)
Gut 52, 1522-1529
   Abstract »    Full Text »    PDF »
Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins.
M. Kim, C. V. Carman, and T. A. Springer (2003)
Science 301, 1720-1725
   Abstract »    Full Text »    PDF »
Identification of Tissue Transglutaminase as a Novel Molecule Involved In Human CD8+ T Cell Transendothelial Migration.
K. Mohan, D. Pinto, and T. B. Issekutz (2003)
J. Immunol. 171, 3179-3186
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Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice.
K. Beider, A. Nagler, O. Wald, S. Franitza, M. Dagan-Berger, H. Wald, H. Giladi, S. Brocke, J. Hanna, O. Mandelboim, et al. (2003)
Blood 102, 1951-1958
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Upregulation of Chemokine Expression in the Retinal Vasculature in Ischemia-Reperfusion Injury.
N. Jo, G.-S. Wu, and N. A. Rao (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4054-4060
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Histamine deficiency in gene-targeted mice strongly reduces antigen-induced airway hyper-responsiveness, eosinophilia and allergen-specific IgE.
G. T. Kozma, G. Losonczy, M. Keszei, Z. Komlosi, E. Buzas, E. Pallinger, J. Appel, T. Szabo, P. Magyar, A. Falus, et al. (2003)
Int. Immunol. 15, 963-973
   Abstract »    Full Text »    PDF »
Association of CC Chemokine Receptor 7 with Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma.
Y. Ding, Y. Shimada, M. Maeda, A. Kawabe, J. Kaganoi, I. Komoto, Y. Hashimoto, M. Miyake, H. Hashida, and M. Imamura (2003)
Clin. Cancer Res. 9, 3406-3412
   Abstract »    Full Text »    PDF »
LDL activates signaling pathways leading to an increase in cytosolic free calcium and stimulation of CD11b expression in monocytes.
K. H. Han, Y. Chen, M. K. Chang, Y. C. Han, J.-H. Park, S. R. Green, A. Boullier, and O. Quehenberger (2003)
J. Lipid Res. 44, 1332-1340
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Expression of Macrophage Inflammatory Protein-3{beta}/CCL19 in Pulmonary Sarcoidosis.
A. Gibejova, F. Mrazek, D. Subrtova, V. Sekerova, J. Szotkowska, V. Kolek, R. M. du Bois, and M. Petrek (2003)
Am. J. Respir. Crit. Care Med. 167, 1695-1703
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T Cells of Atopic Asthmatics Preferentially Infiltrate Into Human Bronchial Xenografts in SCID Mice.
K. Tsumori, H. Kohrogi, E. Goto, N. Hirata, S. Hirosako, K. Fujii, M. Ando, O. Kawano, and H. Mizuta (2003)
J. Immunol. 170, 5712-5718
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L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration.
Z. Ding, T. B. Issekutz, G. P. Downey, and T. K. Waddell (2003)
Blood 101, 4245-4252
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A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow.
R. Alon, M. Aker, S. Feigelson, M. Sokolovsky-Eisenberg, D. E. Staunton, G. Cinamon, V. Grabovsky, R. Shamri, and A. Etzioni (2003)
Blood 101, 4437-4445
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Extracellular Matrix Conditions T Cells for Adhesion to Tissue Interstitium.
K. A. Krivacic and A. D. Levine (2003)
J. Immunol. 170, 5034-5044
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Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis.
W. Weninger, H. S. Carlsen, M. Goodarzi, F. Moazed, M. A. Crowley, E. S. Baekkevold, L. L. Cavanagh, and U. H. von Andrian (2003)
J. Immunol. 170, 4638-4648
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P-Selectin Contributes to Severe Experimental Malaria but Is Not Required for Leukocyte Adhesion to Brain Microvasculature.
W.-L. Chang, J. Li, G. Sun, H.-L. Chen, R. D. Specian, S. M. Berney, D. N. Granger, and H. C. van der Heyde (2003)
Infect. Immun. 71, 1911-1918
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Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse.
D J Mahad, J Lawry, S J. Howell, and M N Woodroofe (2003)
Multiple Sclerosis 9, 189-198
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