Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 16 January 1998:
Vol. 279. no. 5349, pp. 373 - 377
DOI: 10.1126/science.279.5349.373
Prev | Table of Contents | Next

Reports

Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging

Dag Ilver, * Anna Arnqvist, * Johan Ögren, Inga-Maria Frick, Dangeruta Kersulyte, Engin T. Incecik, dagger Douglas E. Berg, Antonello Covacci, Lars Engstrand, ddagger Thomas Borén §

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.

D. Ilver, Department of Microbiology, Umeå University, SE-901 87 Umeå, Sweden.
A. Arnqvist, Department of Microbiology and Department of Oral Biology, Umeå University, SE-901 87 Umeå, Sweden.
J. Ögren and T. Borén, Department of Oral Biology, Umeå University, SE-901 87 Umeå, Sweden.
I.-M. Frick, Department of Cell and Molecular Biology, Lund University, SE-221 00 Lund, Sweden.
D. Kersulyte, E. T. Incecik, D. E. Berg, Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.
A. Covacci, Immunobiological Research Institute Siena, Via Fiorentina 1, 53100 Siena, Italy.
L. Engstrand, Department of Clinical Microbiology and Cancer Epidemiology, University Hospital, SE-751 85 Uppsala, Sweden.
*   These authors contributed equally to this work.

dagger    Present address: Max-von Pettenkofer Institut für Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9A, D-81677 Munich, Germany.

ddagger    Present address: Swedish Institute for Infectious Disease Control, S-105 21, Stockholm, Sweden.

§   To whom correspondence should be addressed. E-mail: thomas.boren{at}micro.umu.se

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa.
A. Magalhaes, J. Gomes, M. N. Ismail, S. M Haslam, N. Mendes, H. Osorio, L. David, J. Le Pendu, R. Haas, A. Dell, et al. (2009)
Glycobiology 19, 1525-1536
   Abstract »    Full Text »    PDF »
Response of Gastric Epithelial Progenitors to Helicobacter pylori Isolates Obtained from Swedish Patients with Chronic Atrophic Gastritis.
M. Giannakis, H. K. Backhed, S. L. Chen, J. J. Faith, M. Wu, J. L. Guruge, L. Engstrand, and J. I. Gordon (2009)
J. Biol. Chem. 284, 30383-30394
   Abstract »    Full Text »    PDF »
Relationship between Alcohol Consumption and Active Helicobacter pylori Infection.
L. Zhang, G. D. Eslick, H. H.-X. Xia, C. Wu, N. Phung, and N. J. Talley (2009)
Alcohol Alcohol.
   Abstract »    Full Text »    PDF »
Outer Membrane Protein Expression Profile in Helicobacter pylori Clinical Isolates.
S. Odenbreit, K. Swoboda, I. Barwig, S. Ruhl, T. Boren, S. Koletzko, and R. Haas (2009)
Infect. Immun. 77, 3782-3790
   Abstract »    Full Text »    PDF »
Role for {alpha}-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells.
T.-W. Liu, C.-W. Ho, H.-H. Huang, S.-M. Chang, S. D. Popat, Y.-T. Wang, M.-S. Wu, Y.-J. Chen, and C.-H. Lin (2009)
PNAS 106, 14581-14586
   Abstract »    Full Text »    PDF »
HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa.
L. Cheng, S. de la Monte, J. Ma, J. Hong, M. Tong, W. Cao, J. Behar, P. Biancani, and K. M. Harnett (2009)
Am J Physiol Gastrointest Liver Physiol 297, G135-G143
   Abstract »    Full Text »    PDF »
Pediatric Helicobacter pylori Isolates Display Distinct Gene Coding Capacities and Virulence Gene Marker Profiles.
S. Talarico, B. D. Gold, J. Fero, D. T. Thompson, J. Guarner, S. Czinn, and N. R. Salama (2009)
J. Clin. Microbiol. 47, 1680-1688
   Abstract »    Full Text »    PDF »
Roles of gastric mucin-type O-glycans in the pathogenesis of Helicobacter pylori infection.
M. Kobayashi, H. Lee, J. Nakayama, and M. Fukuda (2009)
Glycobiology 19, 453-461
   Abstract »    Full Text »    PDF »
Recognition of Blood Group ABH Type 1 Determinants by the FedF Adhesin of F18-fimbriated Escherichia coli.
A. Coddens, M. Diswall, J. Angstrom, M. E. Breimer, B. Goddeeris, E. Cox, and S. Teneberg (2009)
J. Biol. Chem. 284, 9713-9726
   Abstract »    Full Text »    PDF »
Salivary MUC7 is a major carrier of blood group I type O-linked oligosaccharides serving as the scaffold for sialyl Lewis x.
N. G Karlsson and K. A Thomsson (2009)
Glycobiology 19, 288-300
   Abstract »    Full Text »    PDF »
Novel Leb-like Helicobacter pylori-binding glycosphingolipid created by the expression of human {alpha}-1,3/4-fucosyltransferase in FVB/N mouse stomach.
D. Fagerberg, J. Angstrom, A. Halim, A. Hultberg, L. Rakhimova, L. Hammarstrom, T. Boren, and S. Teneberg (2009)
Glycobiology 19, 182-191
   Abstract »    Full Text »    PDF »
Recombination-Based In Vivo Expression Technology Identifies Helicobacter pylori Genes Important for Host Colonization.
A. R. Castillo, A. J. Woodruff, L. E. Connolly, W. E. Sause, and K. M. Ottemann (2008)
Infect. Immun. 76, 5632-5644
   Abstract »    Full Text »    PDF »
Analysis of mucins: role in laboratory diagnosis.
A S Mall (2008)
J. Clin. Pathol. 61, 1018-1024
   Abstract »    Full Text »    PDF »
Regulation of the Helicobacter pylori Cellular Receptor Decay-accelerating Factor.
D. P. O'Brien, J. Romero-Gallo, B. G. Schneider, R. Chaturvedi, A. Delgado, E. J. Harris, U. Krishna, S. R. Ogden, D. A. Israel, K. T. Wilson, et al. (2008)
J. Biol. Chem. 283, 23922-23930
   Abstract »    Full Text »    PDF »
Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction system.
A. C. Goodwin, D. M. Weinberger, C. B. Ford, J. C. Nelson, J. D. Snider, J. D. Hall, C. I. Paules, R. M. Peek Jr, and M. H. Forsyth (2008)
Microbiology 154, 2231-2240
   Abstract »    Full Text »    PDF »
Helicobacter pylori infection and disease: from humans to animal models.
R. M. Peek Jr (2008)
Dis. Model. Mech. 1, 50-55
   Abstract »    Full Text »    PDF »
Review: Prevention of gastric cancer: When is treatment of Helicobacter pylori warranted?.
R. M. Peek Jr (2008)
Therapeutic Advances in Gastroenterology 1, 19-31
   Abstract »    PDF »
Cholesterol Depletion Reduces Helicobacter pylori CagA Translocation and CagA-Induced Responses in AGS Cells.
C.-H. Lai, Y.-C. Chang, S.-Y. Du, H.-J. Wang, C.-H. Kuo, S.-H. Fang, H.-W. Fu, H.-H. Lin, A.-S. Chiang, and W.-C. Wang (2008)
Infect. Immun. 76, 3293-3303
   Abstract »    Full Text »    PDF »
Studies of Lewis antigens and H. pylori adhesion in CHO cell lines engineered to express Lewis b determinants.
J. Lofling, M. Diswall, S. Eriksson, T. Boren, M. E Breimer, and J. Holgersson (2008)
Glycobiology 18, 494-501
   Abstract »    Full Text »    PDF »
{alpha}1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol {alpha}-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth.
H. Lee, P. Wang, H. Hoshino, Y. Ito, M. Kobayashi, J. Nakayama, P. H Seeberger, and M. Fukuda (2008)
Glycobiology 18, 549-558
   Abstract »    Full Text »    PDF »
Novel Protein Antigen (JHP940) from the Genomic Plasticity Region of Helicobacter pylori Induces Tumor Necrosis Factor Alpha and Interleukin-8 Secretion by Human Macrophages.
M. Rizwan, A. Alvi, and N. Ahmed (2008)
J. Bacteriol. 190, 1146-1151
   Abstract »    Full Text »    PDF »
Expression of Helicobacter pylori Virulence Factors and Associated Expression Profiles of Inflammatory Genes in the Human Gastric Mucosa.
S. Wen, D. Velin, C. P. Felley, L. Du, P. Michetti, and Q. Pan-Hammarstrom (2007)
Infect. Immun. 75, 5118-5126
   Abstract »    Full Text »    PDF »
Anti-Lewis X Antibody Promotes Helicobacter pylori Adhesion to Gastric Epithelial Cells.
S.-M. Sheu, B.-S. Sheu, H.-B. Yang, H.-Y. Lei, and J.-J. Wu (2007)
Infect. Immun. 75, 2661-2667
   Abstract »    Full Text »    PDF »
Molecular cloning and characterization of the Caenorhabditis elegans {alpha}1,3-fucosyltransferase family.
K. Nguyen, I. van Die, K. M Grundahl, Z. S Kawar, and R. D Cummings (2007)
Glycobiology 17, 586-599
   Abstract »    Full Text »    PDF »
Essential role of Peyer's patches in the development of Helicobacter-induced gastritis.
K. Kiriya, N. Watanabe, A. Nishio, K. Okazaki, M. Kido, K. Saga, J. Tanaka, T. Akamatsu, S. Ohashi, M. Asada, et al. (2007)
Int. Immunol. 19, 435-446
   Abstract »    Full Text »    PDF »
Structure and Mechanism of Helicobacter pylori Fucosyltransferase: A BASIS FOR LIPOPOLYSACCHARIDE VARIATION AND INHIBITOR DESIGN.
H.-Y. Sun, S.-W. Lin, T.-P. Ko, J.-F. Pan, C.-L. Liu, C.-N. Lin, A. H.-J. Wang, and C.-H. Lin (2007)
J. Biol. Chem. 282, 9973-9982
   Abstract »    Full Text »    PDF »
Functional and Intracellular Signaling Differences Associated with the Helicobacter pylori AlpAB Adhesin from Western and East Asian Strains.
H. Lu, J. Y. Wu, E. J. Beswick, T. Ohno, S. Odenbreit, R. Haas, V. E. Reyes, M. Kita, D. Y. Graham, and Y. Yamaoka (2007)
J. Biol. Chem. 282, 6242-6254
   Abstract »    Full Text »    PDF »
A Distinctive Set of Genes Is Upregulated During the Inflammation-Carcinoma Sequence in Mouse Stomach Infected by Helicobacter felis.
M. Kobayashi, H. Lee, L. Schaffer, T. J. Gilmartin, S. R. Head, S. Takaishi, T. C. Wang, J. Nakayama, and M. Fukuda (2007)
J. Histochem. Cytochem. 55, 263-274
   Abstract »    Full Text »    PDF »
Fucosylation in prokaryotes and eukaryotes.
B. Ma, J. L. Simala-Grant, and D. E. Taylor (2006)
Glycobiology 16, 158R-184R
   Abstract »    Full Text »    PDF »
Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses.
H. M. S. Algood and T. L. Cover (2006)
Clin. Microbiol. Rev. 19, 597-613
   Abstract »    Full Text »    PDF »
Impaired mucus-bicarbonate barrier in Helicobacter pylori-infected mice.
J. Henriksnas, M. Phillipson, M. Storm, L. Engstrand, M. Soleimani, and L. Holm (2006)
Am J Physiol Gastrointest Liver Physiol 291, G396-G403
   Abstract »    Full Text »    PDF »
Pathogenesis of Helicobacter pylori Infection.
J. G. Kusters, A. H. M. van Vliet, and E. J. Kuipers (2006)
Clin. Microbiol. Rev. 19, 449-490
   Abstract »    Full Text »    PDF »
Genotypic Profile of the Outer Membrane Proteins BabA and BabB in Clinical Isolates of Helicobacter pylori.
J. C. Colbeck, L. M. Hansen, J. M. Fong, and J. V. Solnick (2006)
Infect. Immun. 74, 4375-4378
   Abstract »    Full Text »    PDF »
Protein-Protein Interactions among Helicobacter pylori Cag Proteins.
V. J. Busler, V. J. Torres, M. S. McClain, O. Tirado, D. B. Friedman, and T. L. Cover (2006)
J. Bacteriol. 188, 4787-4800
   Abstract »    Full Text »    PDF »
Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys.
H.-P. Wirth, M. Yang, E. Sanabria-Valentin, D. E. Berg, A. Dubois, and M. J. Blaser (2006)
FASEB J 20, 1534-1536
   Abstract »    Full Text »    PDF »
Helicobacter pylori outer membrane proteins and gastroduodenal disease.
Y Yamaoka, O Ojo, S Fujimoto, S Odenbreit, R Haas, O Gutierrez, H M T El-Zimaity, R Reddy, A Arnqvist, and D Y Graham (2006)
Gut 55, 775-781
   Abstract »    Full Text »    PDF »
The Role of Decay-accelerating Factor as a Receptor for Helicobacter pylori and a Mediator of Gastric Inflammation.
D. P. O'Brien, D. A. Israel, U. Krishna, J. Romero-Gallo, J. Nedrud, M. E. Medof, F. Lin, R. Redline, D. M. Lublin, B. J. Nowicki, et al. (2006)
J. Biol. Chem. 281, 13317-13323
   Abstract »    Full Text »    PDF »
Multiple Chromosomal Loci for the babA Gene in Helicobacter pylori..
E. E. Hennig, J. M. Allen, and T. L. Cover (2006)
Infect. Immun. 74, 3046-3051
   Abstract »    Full Text »    PDF »
Terminal {alpha}1,4-linked N-acetylglucosamine in Helicobacter pylori-associated Intestinal Metaplasia of the Human Stomach and Gastric Carcinoma Cell Lines..
B. Ferreira, N. T. Marcos, L. David, J. Nakayama, and C. A. Reis (2006)
J. Histochem. Cytochem. 54, 585-591
   Abstract »    Full Text »    PDF »
Shear Stress, Temperature, and Inoculation Concentration Influence the Adhesion of Water-Stressed Helicobacter pylori to Stainless Steel 304 and Polypropylene.
N. F. Azevedo, A. R. Pinto, N. M. Reis, M. J. Vieira, and C. W. Keevil (2006)
Appl. Envir. Microbiol. 72, 2936-2941
   Abstract »    Full Text »    PDF »
A Helicobacter pylori Vacuolating Toxin Mutant That Fails To Oligomerize Has a Dominant Negative Phenotype.
C. Genisset, C. L. Galeotti, P. Lupetti, D. Mercati, D. A. G. Skibinski, S. Barone, R. Battistutta, M. de Bernard, and J. L. Telford (2006)
Infect. Immun. 74, 1786-1794
   Abstract »    Full Text »    PDF »
HpaA Is Essential for Helicobacter pylori Colonization in Mice.
E. Carlsohn, J. Nystrom, I. Bolin, C. L. Nilsson, and A.-M. Svennerholm (2006)
Infect. Immun. 74, 920-926
   Abstract »    Full Text »    PDF »
Carbohydrate-dependent inhibition of Helicobacter pylori colonization using porcine milk.
A. Gustafsson, A. Hultberg, R. Sjostrom, I. Kacskovics, M. E. Breimer, T. Boren, L. Hammarstrom, and J. Holgersson (2006)
Glycobiology 16, 1-10
   Abstract »    Full Text »    PDF »
A Novel Bacterial Mucinase, Glycosulfatase, Is Associated with Bacterial Vaginosis.
A. M. Roberton, R. Wiggins, P. J. Horner, R. Greenwood, T. Crowley, A. Fernandes, M. Berry, and A. P. Corfield (2005)
J. Clin. Microbiol. 43, 5504-5508
   Abstract »    Full Text »    PDF »
Slow Genetic Divergence of Helicobacter pylori Strains during Long-Term Colonization.
A. Lundin, B. Bjorkholm, I. Kupershmidt, M. Unemo, P. Nilsson, D. I. Andersson, and L. Engstrand (2005)
Infect. Immun. 73, 4818-4822
   Abstract »    Full Text »    PDF »
Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays.
A. Walz, S. Odenbreit, J. Mahdavi, T. Boren, and S. Ruhl (2005)
Glycobiology 15, 700-708
   Abstract »    Full Text »    PDF »
Novel Binding Epitope for Helicobacter pylori Found in Neolacto Carbohydrate Chains: STRUCTURE AND CROSS-BINDING PROPERTIES.
H. Miller-Podraza, B. Lanne, J. Angstrom, S. Teneberg, M. A. Milh, P.-A. Jovall, H. Karlsson, and K.-A. Karlsson (2005)
J. Biol. Chem. 280, 19695-19703
   Abstract »    Full Text »    PDF »
Identification of two new Helicobacter pylori surface proteins involved in attachment to epithelial cell lines.
S. Rubinsztein-Dunlop, B. Guy, L. Lissolo, and H. Fischer (2005)
J. Med. Microbiol. 54, 427-434
   Abstract »    Full Text »    PDF »
The Sialic Acid Binding SabA Adhesin of Helicobacter pylori Is Essential for Nonopsonic Activation of Human Neutrophils.
M. Unemo, M. Aspholm-Hurtig, D. Ilver, J. Bergstrom, T. Boren, D. Danielsson, and S. Teneberg (2005)
J. Biol. Chem. 280, 15390-15397
   Abstract »    Full Text »    PDF »
Phase variation mediated niche adaptation during prolonged experimental murine infection with Helicobacter pylori.
L. Salaun, S. Ayraud, and N. J. Saunders (2005)
Microbiology 151, 917-923
   Abstract »    Full Text »    PDF »
Age-Dependent Changes in Susceptibility of Suckling Mice to Individual Strains of Helicobacter pylori.
H. Suto, M. Zhang, and D. E. Berg (2005)
Infect. Immun. 73, 1232-1234
   Abstract »    Full Text »    PDF »
ABO Blood-group Antigens in Oral Cancer.
E. Dabelsteen and S. Gao (2005)
Journal of Dental Research 84, 21-28
   Abstract »    Full Text »    PDF »
Type V Protein Secretion Pathway: the Autotransporter Story.
I. R. Henderson, F. Navarro-Garcia, M. Desvaux, R. C. Fernandez, and D. Ala'Aldeen (2004)
Microbiol. Mol. Biol. Rev. 68, 692-744
   Abstract »    Full Text »    PDF »
From The Cover: Metastability of Helicobacter pylori bab adhesin genes and dynamics in Lewis b antigen binding.
A. Backstrom, C. Lundberg, D. Kersulyte, D. E. Berg, T. Boren, and A. Arnqvist (2004)
PNAS 101, 16923-16928
   Abstract »    Full Text »    PDF »
Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection.
M. Kawakubo, Y. Ito, Y. Okimura, M. Kobayashi, K. Sakura, S. Kasama, M. N. Fukuda, M. Fukuda, T. Katsuyama, and J. Nakayama (2004)
Science 305, 1003-1006
   Abstract »    Full Text »    PDF »
Molecular Cloning and Characterization of Bifidobacterium bifidum 1,2-{alpha}-L-Fucosidase (AfcA), a Novel Inverting Glycosidase (Glycoside Hydrolase Family 95).
T. Katayama, A. Sakuma, T. Kimura, Y. Makimura, J. Hiratake, K. Sakata, T. Yamanoi, H. Kumagai, and K. Yamamoto (2004)
J. Bacteriol. 186, 4885-4893
   Abstract »    Full Text »    PDF »
Topographical localisation of cagA positive and cagA negative Helicobacter pylori strains in the gastric mucosa; an in situ hybridisation study.
M Camorlinga-Ponce, C Romo, G Gonzalez-Valencia, O Munoz, and J Torres (2004)
J. Clin. Pathol. 57, 822-828
   Abstract »    Full Text »    PDF »
Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin.
M. Aspholm-Hurtig, G. Dailide, M. Lahmann, A. Kalia, D. Ilver, N. Roche, S. Vikstrom, R. Sjostrom, S. Linden, A. Backstrom, et al. (2004)
Science 305, 519-522
   Abstract »    Full Text »    PDF »
Evolutionary and Functional Relationships among the Nontypeable Haemophilus influenzae HMW Family of Adhesins.
A. Z. Buscher, K. Burmeister, S. J. Barenkamp, and J. W. St. Geme III (2004)
J. Bacteriol. 186, 4209-4217
   Abstract »    Full Text »    PDF »
Heterogeneity among Helicobacter pylori Strains in Expression of the Outer Membrane Protein BabA.
E. E. Hennig, R. Mernaugh, J. Edl, P. Cao, and T. L. Cover (2004)
Infect. Immun. 72, 3429-3435
   Abstract »    Full Text »    PDF »
Helicobacter pylori interacts with the human single-domain trefoil protein TFF1.
M. Clyne, P. Dillon, S. Daly, R. O'Kennedy, F. E. B. May, B. R. Westley, and B. Drumm (2004)
PNAS 101, 7409-7414
   Abstract »    Full Text »    PDF »
Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomach.
R. de Jonge, Z. Durrani, S. G. Rijpkema, E. J. Kuipers, A. H.M. van Vliet, and J. G. Kusters (2004)
J. Med. Microbiol. 53, 375-379
   Abstract »    Full Text »    PDF »
The diversity within an expanded and redefined repertoire of phase-variable genes in Helicobacter pylori.
L. Salaun, B. Linz, S. Suerbaum, and N. J. Saunders (2004)
Microbiology 150, 817-830
   Abstract »    Full Text »    PDF »
Isolation and Characterization of a HpyC1I Restriction-Modification System in Helicobacter pylori.
T.-L. Lin, C.-T. Shun, K.-C. Chang, and J.-T. Wang (2004)
J. Biol. Chem. 279, 11156-11162
   Abstract »    Full Text »    PDF »
Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques.
J. V. Solnick, L. M. Hansen, N. R. Salama, J. K. Boonjakuakul, and M. Syvanen (2004)
PNAS 101, 2106-2111
   Abstract »    Full Text »    PDF »
Proteomic Analysis of the Sarcosine-Insoluble Outer Membrane Fraction of Helicobacter pylori Strain 26695.
S.-C. Baik, K.-M. Kim, S.-M. Song, D.-S. Kim, J.-S. Jun, S.-G. Lee, J.-Y. Song, J.-U. Park, H.-L. Kang, W.-K. Lee, et al. (2004)
J. Bacteriol. 186, 949-955
   Abstract »    Full Text »    PDF »
Inflammatory Gene Profiles in Gastric Mucosa during Helicobacter pylori Infection in Humans.
S. Wen, C. P. Felley, H. Bouzourene, M. Reimers, P. Michetti, and Q. Pan-Hammarstrom (2004)
J. Immunol. 172, 2595-2606
   Abstract »    Full Text »    PDF »
Evaluation of the Association of Nine Helicobacter pylori Virulence Factors with Strains Involved in Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma.
P. Lehours, A. Menard, S. Dupouy, B. Bergey, F. Richy, F. Zerbib, A. Ruskone-Fourmestraux, J. C. Delchier, and F. Megraud (2004)
Infect. Immun. 72, 880-888
   Abstract »    Full Text »    PDF »
Helicobacter acinonychis: Genetic and Rodent Infection Studies of a Helicobacter pylori-Like Gastric Pathogen of Cheetahs and Other Big Cats.
D. Dailidiene, G. Dailide, K. Ogura, M. Zhang, A. K. Mukhopadhyay, K. A. Eaton, G. Cattoli, J. G. Kusters, and D. E. Berg (2004)
J. Bacteriol. 186, 356-365
   Abstract »    Full Text »    PDF »
Helicobacter pylori Disrupts STAT1-Mediated Gamma Interferon-Induced Signal Transduction in Epithelial Cells.
D. J. Mitchell, H. Q. Huynh, P. J. M. Ceponis, N. L. Jones, and P. M. Sherman (2004)
Infect. Immun. 72, 537-545
   Abstract »    Full Text »    PDF »
Helicobacter pylori Outer Membrane Vesicles Modulate Proliferation and Interleukin-8 Production by Gastric Epithelial Cells.
S. Ismail, M. B. Hampton, and J. I. Keenan (2003)
Infect. Immun. 71, 5670-5675
   Abstract »    Full Text »    PDF »
Two-Component Systems of Helicobacter pylori Contribute to Virulence in a Mouse Infection Model.
K. Panthel, P. Dietz, R. Haas, and D. Beier (2003)
Infect. Immun. 71, 5381-5385
   Abstract »    Full Text »    PDF »
babA2- and cagA-Positive Helicobacter pylori Strains Are Associated with Duodenal Ulcer and Gastric Carcinoma in Brazil.
A. G. Oliveira, A. Santos, J. B. Guerra, G. A. Rocha, A. M. C. Rocha, C. A. Oliveira, M. M. D. A. Cabral, A. M. M. F. Nogueira, and D. M. M. Queiroz (2003)
J. Clin. Microbiol. 41, 3964-3966
   Abstract »    Full Text »    PDF »
Helicobacter pylori tissue tropism: mouse-colonizing strains can target different gastric niches.
J. K. Akada, K. Ogura, D. Dailidiene, G. Dailide, J. M. Cheverud, and D. E. Berg (2003)
Microbiology 149, 1901-1909
   Abstract »    Full Text »    PDF »
Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection.
B-S Sheu, S-M Sheu, H-B Yang, A-H Huang, and J-J Wu (2003)
Gut 52, 927-932
   Abstract »    Full Text »
Limited Role of Lipopolysaccharide Lewis Antigens in Adherence of Helicobacter pylori to the Human Gastric Epithelium.
J. Mahdavi, T. Boren, C. Vandenbroucke-Grauls, and B. J. Appelmelk (2003)
Infect. Immun. 71, 2876-2880
   Abstract »    Full Text »    PDF »
Glycoconjugate Binding of Gastric and Enterohepatic Helicobacter spp..
S. O. Hynes, S. Teneberg, N. Roche, and T. Wadstrom (2003)
Infect. Immun. 71, 2976-2980
   Abstract »    Full Text »    PDF »
The fdxA Ferredoxin Gene Can Down-Regulate frxA Nitroreductase Gene Expression and Is Essential in Many Strains of Helicobacter pylori.
A. K. Mukhopadhyay, J.-Y. Jeong, D. Dailidiene, P. S. Hoffman, and D. E. Berg (2003)
J. Bacteriol. 185, 2927-2935
   Abstract »    Full Text »    PDF »
Helicobacter pylori babA2, cagA, and s1 vacA genes work synergistically in causing intestinal metaplasia.
C-F Zambon, F Navaglia, D Basso, M Rugge, and M Plebani (2003)
J. Clin. Pathol. 56, 287-291
   Abstract »    Full Text »    PDF »
Generation of Helicobacter pylori Ghosts by PhiX Protein E-Mediated Inactivation and Their Evaluation as Vaccine Candidates.
K. Panthel, W. Jechlinger, A. Matis, M. Rohde, M. Szostak, W. Lubitz, and R. Haas (2003)
Infect. Immun. 71, 109-116
   Abstract »    Full Text »    PDF »
Two Different Families of hopQ Alleles in Helicobacter pylori.
P. Cao and T. L. Cover (2002)
J. Clin. Microbiol. 40, 4504-4511
   Abstract »    Full Text »    PDF »
Helicobacter pylori Infection.
S. Suerbaum and P. Michetti (2002)
N. Engl. J. Med. 347, 1175-1186
   Full Text »    PDF »
High Prevalence of cagA- and babA2-Positive Helicobacter pylori Clinical Isolates in Taiwan.
C.-H. Lai, C.-H. Kuo, Y.-C. Chen, F.-Y. Chao, S.-K. Poon, C.-S. Chang, and W.-C. Wang (2002)
J. Clin. Microbiol. 40, 3860-3862
   Abstract »    Full Text »    PDF »
Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions.
J Yu, W K Leung, M Y Y Go, M C W Chan, K F To, E K W Ng, F K L Chan, T K W Ling, S C S Chung, and J J Y Sung (2002)
Gut 51, 480-484
   Abstract »    Full Text »    PDF »
Colonization of Germ-free Transgenic Mice with Genotyped Helicobacter pylori Strains from a Case-Control Study of Gastric Cancer Reveals a Correlation between Host Responses and HsdS Components of Type I Restriction-Modification Systems.
B. M. Bjorkholm, J. L. Guruge, J. D. Oh, A. J. Syder, N. Salama, K. Guillemin, S. Falkow, C. Nilsson, P. G. Falk, L. Engstrand, et al. (2002)
J. Biol. Chem. 277, 34191-34197
   Abstract »    Full Text »    PDF »
Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation.
J. Mahdavi, B. Sonden, M. Hurtig, F. O. Olfat, L. Forsberg, N. Roche, J. Angstrom, T. Larsson, S. Teneberg, K.-A. Karlsson, et al. (2002)
Science 297, 573-578
   Abstract »    Full Text »    PDF »
Identification of Surface Proteins of Helicobacter pylori by Selective Biotinylation, Affinity Purification, and Two-dimensional Gel Electrophoresis.
N. Sabarth, S. Lamer, U. Zimny-Arndt, P. R. Jungblut, T. F. Meyer, and D. Bumann (2002)
J. Biol. Chem. 277, 27896-27902
   Abstract »    Full Text »    PDF »
Discrimination between Cases of Duodenal Ulcer and Gastritis on the Basis of Putative Virulence Factors of Helicobacter pylori.
Y. Yamaoka, J. Souchek, S. Odenbreit, R. Haas, A. Arnqvist, T. Boren, T. Kodama, M. S. Osato, O. Gutierrez, J. G. Kim, et al. (2002)
J. Clin. Microbiol. 40, 2244-2246
   Abstract »    Full Text »    PDF »
Fuc-TIX: a versatile {alpha}1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile.
S. Toivonen, S. Nishihara, H. Narimatsu, O. Renkonen, and R. Renkonen (2002)
Glycobiology 12, 361-368
   Abstract »    Full Text »    PDF »
Helicobacter pylori adherence to gastric epithelial cells: a role for non-adhesin virulence genes.
Z.-W. ZHANG, N. DORRELL, B. W. WREN, and M. J. G. FARTHING (2002)
J. Med. Microbiol. 51, 495-502
   Abstract »    Full Text »    PDF »
Lactotetraosylceramide, a Novel Glycosphingolipid Receptor for Helicobacter pylori, Present in Human Gastric Epithelium.
S. Teneberg, I. Leonardsson, H. Karlsson, P.-A. Jovall, J. Angstrom, D. Danielsson, I. Naslund, A. Ljungh, T. Wadstrom, and K.-A. Karlsson (2002)
J. Biol. Chem. 277, 19709-19719
   Abstract »    Full Text »    PDF »
Characterization of Two Cryptic Helicobacter pylori Plasmids: a Putative Source for Horizontal Gene Transfer and Gene Shuffling.
D. Hofreuter and R. Haas (2002)
J. Bacteriol. 184, 2755-2766
   Abstract »    Full Text »    PDF »
The Helicobacter pylori Blood Group Antigen-Binding Adhesin Facilitates Bacterial Colonization and Augments a Nonspecific Immune Response.
R. Rad, M. Gerhard, R. Lang, M. Schoniger, T. Rosch, W. Schepp, I. Becker, H. Wagner, and C. Prinz (2002)
J. Immunol. 168, 3033-3041
   Abstract »    Full Text »    PDF »
Functional Analysis of the Helicobacter pylori cag Pathogenicity Island Reveals Both VirD4-CagA-Dependent and VirD4-CagA-Independent Mechanisms.
M. Selbach, S. Moese, T. F. Meyer, and S. Backert (2002)
Infect. Immun. 70, 665-671
   Abstract »    Full Text »    PDF »
Identification of Target Genes Regulated by the Two-Component System HP166-HP165 of Helicobacter pylori.
P. Dietz, G. Gerlach, and D. Beier (2002)
J. Bacteriol. 184, 350-362
   Abstract »    Full Text »    PDF »
Comparison of Genetic Divergence and Fitness between Two Subclones of Helicobacter pylori.
B. Bjorkholm, A. Lundin, A. Sillen, K. Guillemin, N. Salama, C. Rubio, J. I. Gordon, P. Falk, and L. Engstrand (2001)
Infect. Immun. 69, 7832-7838
   Abstract »    Full Text »    PDF »
Helicobacter pylori cytotoxin VacA increases alkaline secretion in gastric epithelial cells.
L. Debellis, E. Papini, R. Caroppo, C. Montecucco, and S. Curci (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1440-G1448
   Abstract »    Full Text »    PDF »
Comparison of Genomic Structures and Antigenic Reactivities of Orthologous 29-Kilodalton Outer Membrane Proteins of Helicobacter pylori.
A. Sumie, T. Yamashiro, K. Nakashima, M. Nasu, M. Watanabe, and A. Nishizono (2001)
Infect. Immun. 69, 6846-6852
   Abstract »    Full Text »    PDF »
Helicobacter pylori-binding gangliosides of human gastric adenocarcinoma.
N. Roche, T. Larsson, J. Angstrom, and S. Teneberg (2001)
Glycobiology 11, 935-944
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)