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Science 9 January 1998:
Vol. 279. no. 5348, pp. 237 - 242
DOI: 10.1126/science.279.5348.237
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Reports

Functional Expression of a Mammalian Odorant Receptor

Haiqing Zhao, Lidija Ivic, Joji M. Otaki, Mitsuhiro Hashimoto, Katsuhiro Mikoshiba, Stuart Firestein *

Candidate mammalian odorant receptors were first cloned some 6 years ago. The physiological function of these receptors in initiating transduction in olfactory receptor neurons remains to be established. Here, a recombinant adenovirus was used to drive expression of a particular receptor gene in an increased number of sensory neurons in the rat olfactory epithelium. Electrophysiological recording showed that increased expression of a single gene led to greater sensitivity to a small subset of odorants.

H. Zhao, Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA.
L. Ivic, J. M. Otaki, S. Firestein, Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
M. Hashimoto and K. Mikoshiba, Molecular Neurobiology Lab, Tsukuba Life Sciences Center, RIKEN, Tsukuba, Ibaraki 305, Japan.
*   To whom correspondence should be addressed.

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