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Science 28 November 1997:
Vol. 278. no. 5343, pp. 1626 - 1629
DOI: 10.1126/science.278.5343.1626
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Reports

CD1d-Restricted and TCR-Mediated Activation of Valpha14 NKT Cells by Glycosylceramides

Tetsu Kawano, Junqing Cui, Yasuhiko Koezuka, Isao Toura, Yoshikatsu Kaneko, Kazuhiro Motoki, Hitomi Ueno, Ryusuke Nakagawa, Hiroshi Sato, Eisuke Kondo, Haruhiko Koseki, Masaru Taniguchi *

Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the Valpha 14 and Jalpha 281 gene segments. A glycosylceramide-containing alpha -anomeric sugar with a longer fatty acyl chain (C26) and sphingosine base (C18) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of Valpha 14 NKT cells were abrogated by treatment with chloroquine-concanamycin A or by monoclonal antibodies against CD1d/Vbeta 8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells.

T. Kawano, J. Cui, I. Toura, Y. Kaneko, H. Sato, E. Kondo, H. Koseki, M. Taniguchi, CREST (Core Research for Evolutional Science and Technology) Project, Japan Science and Technology Corporation (JST), and Division of Molecular Immunology, Center for Biomedical Science, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo, Chiba 260, Japan.
Y. Koezuka, K. Motoki, H. Ueno, R. Nakagawa, Pharmaceutical Research Laboratory, Kirin Brewery, 3 Miyahara, Takasaki, Gunma 370-12, Japan.
*   To whom correspondence should be addressed. E-mail: taniguti{at}med.m.chiba-u.ac.jp

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Hyporesponsiveness to Natural Killer T-Cell Ligand {alpha}-Galactosylceramide in Cancer-Bearing State Mediated by CD11b+ Gr-1+ Cells Producing Nitric Oxide.
K. Yanagisawa, M. A. Exley, X. Jiang, N. Ohkochi, M. Taniguchi, and K.-i. Seino (2006)
Cancer Res. 66, 11441-11446
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IFN-beta-Mediated Up-Regulation of CD1d in Bacteria-Infected APCs.
G. Raghuraman, Y. Geng, and C.-R. Wang (2006)
J. Immunol. 177, 7841-7848
   Abstract »    Full Text »    PDF »
GATA-3 Regulates the Development and Function of Invariant NKT Cells.
P. J. Kim, S.-Y. Pai, M. Brigl, G. S. Besra, J. Gumperz, and I-C. Ho (2006)
J. Immunol. 177, 6650-6659
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CD4+ T Cells in the Absence of the CD8+ Cytotoxic T Cells Are Critical and Sufficient for NKT Cell-Dependent Tumor Rejection.
C. Hong, H. Lee, M. Oh, C.-Y. Kang, S. Hong, and S.-H. Park (2006)
J. Immunol. 177, 6747-6757
   Abstract »    Full Text »    PDF »
CD1 Antigen Presentation by Human Dendritic Cells as a Target for Herpes Simplex Virus Immune Evasion.
M. J. Raftery, F. Winau, S. H. E. Kaufmann, U. E. Schaible, and G. Schonrich (2006)
J. Immunol. 177, 6207-6214
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PPAR{gamma} controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells.
I. Szatmari, A. Pap, R. Ruhl, J.-X. Ma, P. A. Illarionov, G. S. Besra, E. Rajnavolgyi, B. Dezso, and L. Nagy (2006)
J. Exp. Med. 203, 2351-2362
   Abstract »    Full Text »    PDF »
Chewing the fat on natural killer T cell development.
D. I. Godfrey, M. J. McConville, and D. G. Pellicci (2006)
J. Exp. Med. 203, 2229-2232
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Rapid Development of a Gamma Interferon-Secreting Glycolipid/CD1d-Specific V{alpha}14+ NK1.1- T-Cell Subset after Bacterial Infection..
M. Emoto, I. Yoshizawa, Y. Emoto, M. Miamoto, R. Hurwitz, and S. H. E. Kaufmann (2006)
Infect. Immun. 74, 5903-5913
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Glucocerebroside Ameliorates the Metabolic Syndrome in OB/OB Mice.
M. Margalit, Z. Shalev, O. Pappo, M. Sklair-Levy, R. Alper, M. Gomori, D. Engelhardt, E. Rabbani, and Y. Ilan (2006)
J. Pharmacol. Exp. Ther. 319, 105-110
   Abstract »    Full Text »    PDF »
Structural Characterization of Mycobacterial Phosphatidylinositol Mannoside Binding to Mouse CD1d.
D. M. Zajonc, G. D. Ainge, G. F. Painter, W. B. Severn, and I. A. Wilson (2006)
J. Immunol. 177, 4577-4583
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Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma.
S. Sengupta, J. A. den Boon, I-H. Chen, M. A. Newton, D. B. Dahl, M. Chen, Y.-J. Cheng, W. H. Westra, C.-J. Chen, A. Hildesheim, et al. (2006)
Cancer Res. 66, 7999-8006
   Abstract »    Full Text »    PDF »
Improving Antitumor Immune Responses by Circumventing Immunoregulatory Cells and Mechanisms..
G. Lizee, L. G. Radvanyi, W. W. Overwijk, and P. Hwu (2006)
Clin. Cancer Res. 12, 4794-4803
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Dendritic cells pulsed with alpha-galactosylceramide induce anti-tumor immunity against pancreatic cancer in vivo.
S Nagaraj, C Ziske, J Strehl, D Messmer, T Sauerbruch, and I. Schmidt-Wolf (2006)
Int. Immunol. 18, 1279-1283
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CD1d Ligands: The Good, the Bad, and the Ugly.
R. R. Brutkiewicz (2006)
J. Immunol. 177, 769-775
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Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells.
C. J. Montoya, H.-B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson (2006)
J. Immunol. 177, 1028-1039
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T-cell recognition of glycolipids presented by CD1 proteins.
D. C. Young and D. B. Moody (2006)
Glycobiology 16, 103R-112R
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Dual function for the adaptor MIST in IFN-{gamma} production by NK and CD4+NKT cells regulated by the Src kinase Fgr.
H. Sasanuma, A. Tatsuno, S. Hidano, K. Ohshima, Y. Matsuzaki, K. Hayashi, C. A. Lowell, D. Kitamura, and R. Goitsuka (2006)
Blood 107, 3647-3655
   Abstract »    Full Text »    PDF »


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