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Science 17 October 1997:
Vol. 278. no. 5337, pp. 474 - 476
DOI: 10.1126/science.278.5337.474
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Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes

S. A. Anderson, D. D. Eisenstat, L. Shi, J. L. R. Rubenstein *

Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma -aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.

Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, and Biomedical Sciences, 401 Parnassus Avenue, University of California at San Francisco, CA 94143-0984, USA.
*   To whom correspondence should be addressed. E-mail: jlrr{at}cgl.ucsf.edu

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