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Science 26 September 1997:
Vol. 277. no. 5334, p. 1950
DOI: 10.1126/science.277.5334.1950
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Perspectives

IMMUNOLOGY:
Lymphocyte Survival: A Red Queen Hypothesis

Antonio A. Freitas and Benedita Rocha

A pool of immune cells lies apparently dormant in the body, ready to become activated if awakened by a foreign antigen. In a Perspective Freitas and Rocha discuss the new finding (reported on page 1986 of this issue) that in fact these cells are waiting quite actively, kept in a receptive state by the presence of a transcription factor, LKLF.

A. A. Freitas is in the Laboratoire des Dynamiques Lymphocytaires, Institut Pasteur CNRS URA 1961, 75015 Paris, France. E-mail: afreitas{at}pasteur.fr B. Rocha is at INSERM U345, Institut Necker, 75015 Paris, France.

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