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Science 12 September 1997:
Vol. 277. no. 5332, pp. 1630 - 1635
DOI: 10.1126/science.277.5332.1630
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Articles

STATs and Gene Regulation

James E. Darnell Jr.

STATs (signal transducers and activators of transcription) are a family of latent cytoplasmic proteins that are activated to participate in gene control when cells encounter various extracellular polypeptides. Biochemical and molecular genetic explorations have defined a single tyrosine phosphorylation site and, in a dimeric partner molecule, an Src homology 2 (SH2) phosphotyrosine-binding domain, a DNA interaction domain, and a number of protein-protein interaction domains (with receptors, other transcription factors, the transcription machinery, and perhaps a tyrosine phosphatase). Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient evolutionary origin for this dual-function set of proteins.

The author is in the Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA.

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   Abstract »    Full Text »    PDF »
Cardioprotection by Ischemic Postconditioning Is Lost in Aged and STAT3-Deficient Mice.
K. Boengler, A. Buechert, Y. Heinen, C. Roeskes, D. Hilfiker-Kleiner, G. Heusch, and R. Schulz (2008)
Circ. Res. 102, 131-135
   Abstract »    Full Text »    PDF »
Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy.
S. Choi and J.N. Myers (2008)
Journal of Dental Research 87, 14-32
   Abstract »    Full Text »    PDF »
Airway Smooth Muscle Cell as an Inflammatory Cell: Lessons Learned from Interferon Signaling Pathways.
O. Tliba and Y. Amrani (2008)
Proceedings of the ATS 5, 106-112
   Abstract »    Full Text »    PDF »
Estrogen and Progesterone are Critical Regulators of Stat5a Expression in the Mouse Mammary Gland.
S. J. Santos, S. Z. Haslam, and S. E. Conrad (2008)
Endocrinology 149, 329-338
   Abstract »    Full Text »    PDF »
Interferon {alpha} Induces Nucleus-independent Apoptosis by Activating Extracellular Signal-regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase Downstream of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin.
T. Panaretakis, L. Hjortsberg, K. P. Tamm, A.-C. Bjorklund, B. Joseph, and D. Grander (2008)
Mol. Biol. Cell 19, 41-50
   Abstract »    Full Text »    PDF »
Leptin Sensitivity in the Developing Rat Hypothalamus.
A.-S. Carlo, M. Pyrski, C. Loudes, A. Faivre-Baumann, J. Epelbaum, L. M. Williams, and W. Meyerhof (2007)
Endocrinology 148, 6073-6082
   Abstract »    Full Text »    PDF »
8-Benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic Acid (SD-1008), a Novel Janus Kinase 2 Inhibitor, Increases Chemotherapy Sensitivity in Human Ovarian Cancer Cells.
Z. Duan, J. Bradner, E. Greenberg, R. Mazitschek, R. Foster, J. Mahoney, and M. V. Seiden (2007)
Mol. Pharmacol. 72, 1137-1145
   Abstract »    Full Text »    PDF »
Role of the JAK/STAT Pathway in the Regulation of Interleukin-8 Transcription by Oxidized Phospholipids in Vitro and in Atherosclerosis in Vivo.
N. M. Gharavi, J. A. Alva, K. P. Mouillesseaux, C. Lai, M. Yeh, W. Yeung, J. Johnson, W. L. Szeto, L. Hong, M. Fishbein, et al. (2007)
J. Biol. Chem. 282, 31460-31468
   Abstract »    Full Text »    PDF »
Inflammation Activates the Interferon Signaling Pathways in Taste Bud Cells.
H. Wang, M. Zhou, J. Brand, and L. Huang (2007)
J. Neurosci. 27, 10703-10713
   Abstract »    Full Text »    PDF »
Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo.
N. A. Jewell, N. Vaghefi, S. E. Mertz, P. Akter, R. S. Peebles Jr., L. O. Bakaletz, R. K. Durbin, E. Flano, and J. E. Durbin (2007)
J. Virol. 81, 9790-9800
   Abstract »    Full Text »    PDF »
Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.
K. H. Clodfelter, G. D. Miles, V. Wauthier, M. G. Holloway, X. Zhang, P. Hodor, W. J. Ray, and D. J. Waxman (2007)
Physiol Genomics 31, 63-74
   Abstract »    Full Text »    PDF »
In spermatozoa, Stat1 is activated during capacitation and the acrosomal reaction.
Y. Bastian, A. Zepeda-Bastida, S. Uribe, and A. Mujica (2007)
Reproduction 134, 425-433
   Abstract »    Full Text »    PDF »
Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes.
O. Norkina, A. Dolganiuc, T. Shapiro, K. Kodys, P. Mandrekar, and G. Szabo (2007)
J. Leukoc. Biol. 82, 752-762
   Abstract »    Full Text »    PDF »
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
F. A. Masri, W. Xu, S. A. A. Comhair, K. Asosingh, M. Koo, A. Vasanji, J. Drazba, B. Anand-Apte, and S. C. Erzurum (2007)
Am J Physiol Lung Cell Mol Physiol 293, L548-L554
   Abstract »    Full Text »    PDF »
Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function.
X. Dai, Y. Chen, L. Di, A. Podd, G. Li, K. D. Bunting, L. Hennighausen, R. Wen, and D. Wang (2007)
J. Immunol. 179, 1068-1079
   Abstract »    Full Text »    PDF »


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